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case study rheumatoid arthritis hypertension typhoid pneumonia dilated cardiomyopathy pulmonary arterial hypertension erosive gastritis plasmodium falciparum malaria thrombocytopenia viral hepatitis urinary tract infection iron deficiency anaemia congestive cardiac failure chronic alcoholic liver disease chronic kidney disease kidney failure convulsions epilepsy lactational amenorrhoea diabetes mellitus type 1 diabetic ketoacidosis enteric fever cigarettes smoking ill effects nervous system plant cell components zika vírus pandemic