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clinical trials datatrak edc eclinical risked-based monitoring fda gamification rbm esource cdm clinical trial management clinical trial dia clinical data management electronic data capture risk-based datatrak one risk based monitoring risk-based monitoring capabilities implementation transcelerate biopharma central monitoring requirements onemedplace birch solution clinical trials solutions transcelerate clinical operations data integration academia technology dtcc learning saas cloud risk management eclinical solutions clini clinical sites clinical sites mid-study changes td3 cdisc clinical trial solution