Personal Information
Organization / Workplace
San Francisco Bay Area United States
Occupation
Professor
Industry
Medical / Health Care / Pharmaceuticals
About
My research is focused on (1) development of angiogenic gene and cell therapies for ischemic stroke; and (2) development of animal models for untangling the underlying etiopathogenesis and testing novel therapeutic strategies for cerebrovascular malformation. I have generated a custom-designed adeno-associated viral vector (AAV) that can mediate targeted gene expression in ischemic tissues. I am using the following strategies to develop brain AVM model in the adult mouse: (a) genetic manipulation using transgenic or knockout mice; (b) block ligand-receptor binding by overexpression of soluble proteins; (c) focal angiogenic stimulation by AAV mediated VEGF gene transfer; and (d) altering...
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