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In Drug Metabolism is the process of converting a drug into product or inert substances after or before reaching at the site of action.
Metabolism plays an important role in elimination of drugs and foreign substance from the body.
The metabolism of any drug is generally characterised by two phases of reaction
1.Metabolic transformation ( biotransformation ) and
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Reaction type of Phase-I:
1.Oxidation
2.Reduction
3.Hydrolysis
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Example: Metabolism of Aspirin
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In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
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2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
9.Amino Acid Conjugation
10.Fatty Acid and Cholesterol Conjugation
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Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
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4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
8.Tamoxifen (Breast Cancer drug )
9.Clozapine(Antipsychotic)
These drugs are differentiates with the TOXIC METABOLITE , TOXICITY OF METABOLITE.
References for this topic also mentioned at the end.Decision Tree-ID3,C4.5,CART,Regression Tree
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Principal Satbir Singh writes Kaba and Kitab i.e. Building Harmandir Sahib and Compilation of Granth Sahib gave Sikhs a central place of worship and a Holy book is the single most important reason for Sikhism to flourish as a new religion which gave them a identity which was separate from Hindus and Muslims.
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Powerpoint introductorio en ingl辿s sobre el Romanticismo.Low Vison introduction from Aligarh Muslim University
Low Vison introduction from Aligarh Muslim UniversityAligarh Muslim University, Aligarh, Uttar Pradesh, India
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Optical and non optical devices used in low vision
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