After medical school, I was working as a chest surgeon from 2001 to 2008. Throughout my career as a surgeon treating tumours and involved in lung transplantations, I was in a quandary over seemingly opposing immunological issues. In tumour immunotherapy it was implausible to activate tumour-specific immune responses, and conversely, in transplantation it was unfeasible to suppress allograft specific immune response.
By studying the function and generation of regulatory T cells, it may be possible to establish a method for controlling antigen specific immune responses by inducing or blocking activities of regulatory T cells and improving the prognosis of advanced cancer and transplantatio...