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drug testing preclinical studies preclinical toxicity testing cpcsea ethics committee iaec drug evaluation dose selection laboratory animals preclinical testing hypersensitivity testing skin sensitisation testing mouse guinea pig 420 safety testing limit dose rat oecd drug oral toxicity albuminuria esrd segment iii segment ii segment i carcinogenicity testing female reproduction and developmental toxicity stu good laboratory practices genetically modified animals reduction refinement replacement alternatives to animal studies unsaturation isomerism chemical structure and physiologic activity effect of functional groups sar chemical decomposition physical degradation influence of temperature on drug influence of light on drug storage chemical stability testing laboratory animal testing diabetic kidney disease