際際滷shows by User: BibinMathew8 / http://www.slideshare.net/images/logo.gif 際際滷shows by User: BibinMathew8 / Thu, 12 Mar 2015 00:42:38 GMT 際際滷Share feed for 際際滷shows by User: BibinMathew8 Challenges in trancorneal drug delivery /slideshow/chall/45737160 presentation1-150312004238-conversion-gate01
Ophthalmic drug delivery is one of the challenging endeavors which is being faced by the pharmaceutical scientist, owing to the anatomy, physiology, and biochemistry of the eye, that renders it impervious to foreign substances. Topical administration of ophthalmic medications is the most common method for treating conditions that affect the exterior parts of the eye. The unique anatomy and physiology of the eye makes it difficult to achieve an effective drug concentration at the target site. Therefore, the major challenge remains to efficiently deliver a drug past the protective ocular barriers accompanied with a minimization of its systemic side effects.Conventional eye drops currently account for more than 90% of the marketed ophthalmic formulations. However, after instillation of an eye drop, only a small amount of the applied drug penetrates the cornea and reaches the intraocular tissues, which is due to the rapid and extensive precorneal loss caused by drainage and high tear fluid turn-over. Tear drainage leads to absorption of the administered dose by the nasolacrimal duct, leading to side effects. As a consequence of the precorneal loss, the ocular bioavailability is usually less than 10%. Furthermore, rapid elimination of the eye drops administered often results in a short duration of action which leads to increase in frequency of administration. A medication is applied to the eye to treat the diseases on the surface of the eye such as conjunctivitis, blepharitis, and keratitis sicca, as well as to provide intraocular treatment through the cornea for diseases such as glaucoma and uveitis. Topical administration of antibacterial medication to the conjunctival sac is usually an effective avenue for treating bacterial conjunctivitis.[2] An ideal topical drug delivery system should possess the following characteristics: 1. Good corneal and conjunctival penetration. 2. Prolonged precorneal residence time. 3. Easy instillation. 4. Appropriate rheological properties.]]>
Ophthalmic drug delivery is one of the challenging endeavors which is being faced by the pharmaceutical scientist, owing to the anatomy, physiology, and biochemistry of the eye, that renders it impervious to foreign substances. Topical administration of ophthalmic medications is the most common method for treating conditions that affect the exterior parts of the eye. The unique anatomy and physiology of the eye makes it difficult to achieve an effective drug concentration at the target site. Therefore, the major challenge remains to efficiently deliver a drug past the protective ocular barriers accompanied with a minimization of its systemic side effects.Conventional eye drops currently account for more than 90% of the marketed ophthalmic formulations. However, after instillation of an eye drop, only a small amount of the applied drug penetrates the cornea and reaches the intraocular tissues, which is due to the rapid and extensive precorneal loss caused by drainage and high tear fluid turn-over. Tear drainage leads to absorption of the administered dose by the nasolacrimal duct, leading to side effects. As a consequence of the precorneal loss, the ocular bioavailability is usually less than 10%. Furthermore, rapid elimination of the eye drops administered often results in a short duration of action which leads to increase in frequency of administration. A medication is applied to the eye to treat the diseases on the surface of the eye such as conjunctivitis, blepharitis, and keratitis sicca, as well as to provide intraocular treatment through the cornea for diseases such as glaucoma and uveitis. Topical administration of antibacterial medication to the conjunctival sac is usually an effective avenue for treating bacterial conjunctivitis.[2] An ideal topical drug delivery system should possess the following characteristics: 1. Good corneal and conjunctival penetration. 2. Prolonged precorneal residence time. 3. Easy instillation. 4. Appropriate rheological properties.]]> Thu, 12 Mar 2015 00:42:38 GMT /slideshow/chall/45737160 BibinMathew8@slideshare.net(BibinMathew8) Challenges in trancorneal drug delivery BibinMathew8 Ophthalmic drug delivery is one of the challenging endeavors which is being faced by the pharmaceutical scientist, owing to the anatomy, physiology, and biochemistry of the eye, that renders it impervious to foreign substances. Topical administration of ophthalmic medications is the most common method for treating conditions that affect the exterior parts of the eye. The unique anatomy and physiology of the eye makes it difficult to achieve an effective drug concentration at the target site. Therefore, the major challenge remains to efficiently deliver a drug past the protective ocular barriers accompanied with a minimization of its systemic side effects.Conventional eye drops currently account for more than 90% of the marketed ophthalmic formulations. However, after instillation of an eye drop, only a small amount of the applied drug penetrates the cornea and reaches the intraocular tissues, which is due to the rapid and extensive precorneal loss caused by drainage and high tear fluid turn-over. Tear drainage leads to absorption of the administered dose by the nasolacrimal duct, leading to side effects. As a consequence of the precorneal loss, the ocular bioavailability is usually less than 10%. Furthermore, rapid elimination of the eye drops administered often results in a short duration of action which leads to increase in frequency of administration. A medication is applied to the eye to treat the diseases on the surface of the eye such as conjunctivitis, blepharitis, and keratitis sicca, as well as to provide intraocular treatment through the cornea for diseases such as glaucoma and uveitis. Topical administration of antibacterial medication to the conjunctival sac is usually an effective avenue for treating bacterial conjunctivitis.[2] An ideal topical drug delivery system should possess the following characteristics: 1. Good corneal and conjunctival penetration. 2. Prolonged precorneal residence time. 3. Easy instillation. 4. Appropriate rheological properties. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/presentation1-150312004238-conversion-gate01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Ophthalmic drug delivery is one of the challenging endeavors which is being faced by the pharmaceutical scientist, owing to the anatomy, physiology, and biochemistry of the eye, that renders it impervious to foreign substances. Topical administration of ophthalmic medications is the most common method for treating conditions that affect the exterior parts of the eye. The unique anatomy and physiology of the eye makes it difficult to achieve an effective drug concentration at the target site. Therefore, the major challenge remains to efficiently deliver a drug past the protective ocular barriers accompanied with a minimization of its systemic side effects.Conventional eye drops currently account for more than 90% of the marketed ophthalmic formulations. However, after instillation of an eye drop, only a small amount of the applied drug penetrates the cornea and reaches the intraocular tissues, which is due to the rapid and extensive precorneal loss caused by drainage and high tear fluid turn-over. Tear drainage leads to absorption of the administered dose by the nasolacrimal duct, leading to side effects. As a consequence of the precorneal loss, the ocular bioavailability is usually less than 10%. Furthermore, rapid elimination of the eye drops administered often results in a short duration of action which leads to increase in frequency of administration. A medication is applied to the eye to treat the diseases on the surface of the eye such as conjunctivitis, blepharitis, and keratitis sicca, as well as to provide intraocular treatment through the cornea for diseases such as glaucoma and uveitis. Topical administration of antibacterial medication to the conjunctival sac is usually an effective avenue for treating bacterial conjunctivitis.[2] An ideal topical drug delivery system should possess the following characteristics: 1. Good corneal and conjunctival penetration. 2. Prolonged precorneal residence time. 3. Easy instillation. 4. Appropriate rheological properties.
Challenges in trancorneal drug delivery from Bibin Mathew
]]> 1180 5 https://cdn.slidesharecdn.com/ss_thumbnails/presentation1-150312004238-conversion-gate01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Interpretation and Management of Pancreatic cancer /BibinMathew8/inpancreatic-cancer pancreaticcancer-140207000032-phpapp02
A descriptive approach for interpretation and managent of pancreatic cancer.]]>
A descriptive approach for interpretation and managent of pancreatic cancer.]]> Fri, 07 Feb 2014 00:00:32 GMT /BibinMathew8/inpancreatic-cancer BibinMathew8@slideshare.net(BibinMathew8) Interpretation and Management of Pancreatic cancer BibinMathew8 A descriptive approach for interpretation and managent of pancreatic cancer. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/pancreaticcancer-140207000032-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> A descriptive approach for interpretation and managent of pancreatic cancer.
Interpretation and Management of Pancreatic cancer from Bibin Mathew
]]> 2102 22 https://cdn.slidesharecdn.com/ss_thumbnails/pancreaticcancer-140207000032-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-BibinMathew8-48x48.jpg?cb=1427351980 https://cdn.slidesharecdn.com/ss_thumbnails/presentation1-150312004238-conversion-gate01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/chall/45737160 Challenges in trancorn... https://cdn.slidesharecdn.com/ss_thumbnails/pancreaticcancer-140207000032-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds BibinMathew8/inpancreatic-cancer Interpretation and Man...