ºÝºÝߣshows by User: cressetgroup / http://www.slideshare.net/images/logo.gif ºÝºÝߣshows by User: cressetgroup / Wed, 25 Jun 2014 03:09:12 GMT ºÝºÝߣShare feed for ºÝºÝߣshows by User: cressetgroup Selectivity mining – multiple activities in Activity Miner /slideshow/selectivity-mining-multiple-activities-in-activity-miner/36279244 iccs-activitycliffsaspresentedfbcemartinslater-140625030912-phpapp01
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Wed, 25 Jun 2014 03:09:12 GMT /slideshow/selectivity-mining-multiple-activities-in-activity-miner/36279244 cressetgroup@slideshare.net(cressetgroup) Selectivity mining – multiple activities in Activity Miner cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/iccs-activitycliffsaspresentedfbcemartinslater-140625030912-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Selectivity mining – multiple activities in Activity Miner from Cresset
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Discovery and optimization of novel small molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement /slideshow/discovery-and-optimization-of-novel-small-molecule-hiv1-entry-inhibitors-using-fieldbased-virtual-screening-and-bioisosteric-replacement/36249147 cocklin-cressetusergroupmeeting2014-140624104502-phpapp01
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Tue, 24 Jun 2014 10:45:02 GMT /slideshow/discovery-and-optimization-of-novel-small-molecule-hiv1-entry-inhibitors-using-fieldbased-virtual-screening-and-bioisosteric-replacement/36249147 cressetgroup@slideshare.net(cressetgroup) Discovery and optimization of novel small molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/cocklin-cressetusergroupmeeting2014-140624104502-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Discovery and optimization of novel small molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement from Cresset
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Can field based chemistry help us to predict protein-DNA binding sites? /slideshow/can-field-based-chemistry-help-us-to-predict-proteindna-binding-sites/36249060 fieldbasedchemistryspring2014barr-140624104253-phpapp02
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Tue, 24 Jun 2014 10:42:53 GMT /slideshow/can-field-based-chemistry-help-us-to-predict-proteindna-binding-sites/36249060 cressetgroup@slideshare.net(cressetgroup) Can field based chemistry help us to predict protein-DNA binding sites? cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/fieldbasedchemistryspring2014barr-140624104253-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Can field based chemistry help us to predict protein-DNA binding sites? from Cresset
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Organic converstions: an aid in perspective /slideshow/organic-converstions-an-aid-in-perspective/36248948 lewiswhiteheadcressetugmorganicconversions-anaidinperspectivefinal-140624104012-phpapp02
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Tue, 24 Jun 2014 10:40:12 GMT /slideshow/organic-converstions-an-aid-in-perspective/36248948 cressetgroup@slideshare.net(cressetgroup) Organic converstions: an aid in perspective cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/lewiswhiteheadcressetugmorganicconversions-anaidinperspectivefinal-140624104012-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Organic converstions: an aid in perspective from Cresset
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Identification of novel potential anti cancer agents using network pharmacology based computational modelling /slideshow/identification-of-novel-potential-anti-cancer-agents-using-network-pharmacology-based-computational-modelling/36248570 identificationofnovelpotentialanti-canceragentsusingnetworkpharmacologybasedcomputationalmodellingbe-140624103117-phpapp01
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Tue, 24 Jun 2014 10:31:17 GMT /slideshow/identification-of-novel-potential-anti-cancer-agents-using-network-pharmacology-based-computational-modelling/36248570 cressetgroup@slideshare.net(cressetgroup) Identification of novel potential anti cancer agents using network pharmacology based computational modelling cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/identificationofnovelpotentialanti-canceragentsusingnetworkpharmacologybasedcomputationalmodellingbe-140624103117-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Identification of novel potential anti cancer agents using network pharmacology based computational modelling from Cresset
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Knowledge-based chemical fragment analysis in protein binding sites /slideshow/knowledgebased-chemical-fragment-analysis-in-protein-binding-sites/36247950 chanfieldsknowledge-basedchemicalfragmentanalysisinproteinbindingsites-140624101907-phpapp01
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Tue, 24 Jun 2014 10:19:07 GMT /slideshow/knowledgebased-chemical-fragment-analysis-in-protein-binding-sites/36247950 cressetgroup@slideshare.net(cressetgroup) Knowledge-based chemical fragment analysis in protein binding sites cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/chanfieldsknowledge-basedchemicalfragmentanalysisinproteinbindingsites-140624101907-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Knowledge-based chemical fragment analysis in protein binding sites from Cresset
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Using waterswap to predict and understand binding affinities /slideshow/using-waterswap-to-predict-and-understand-binding-affinities/36247590 usingwaterswaptopredictandunderstandbindingaffinitieschristopherwoods-140624101204-phpapp01
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Tue, 24 Jun 2014 10:12:04 GMT /slideshow/using-waterswap-to-predict-and-understand-binding-affinities/36247590 cressetgroup@slideshare.net(cressetgroup) Using waterswap to predict and understand binding affinities cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/usingwaterswaptopredictandunderstandbindingaffinitieschristopherwoods-140624101204-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Using waterswap to predict and understand binding affinities from Cresset
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Smart drug re-profiling using computational chemistry tools novel biology and pharmacological insights /slideshow/re-pharm-corporate-presentation-cresset-ugm-2014/36247202 re-pharm-corporatepresentation-cressetugm2014-140624100402-phpapp01
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Tue, 24 Jun 2014 10:04:02 GMT /slideshow/re-pharm-corporate-presentation-cresset-ugm-2014/36247202 cressetgroup@slideshare.net(cressetgroup) Smart drug re-profiling using computational chemistry tools novel biology and pharmacological insights cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/re-pharm-corporatepresentation-cressetugm2014-140624100402-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Smart drug re-profiling using computational chemistry tools novel biology and pharmacological insights from Cresset
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New features in cresst products /slideshow/new-features-in-cresst-products/36246824 newfeaturesincresstproductstimcheeseright-140624095609-phpapp01
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Tue, 24 Jun 2014 09:56:09 GMT /slideshow/new-features-in-cresst-products/36246824 cressetgroup@slideshare.net(cressetgroup) New features in cresst products cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/newfeaturesincresstproductstimcheeseright-140624095609-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
New features in cresst products from Cresset
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Comparing the electrostatic properties of protein active sites and other cresset research /slideshow/comparing-the-electrostatic-properties-of-protein-active-sites-and-other-cresset-research/36246243 comparingtheelectrostaticpropertiesofproteinactivesitesandothercressetresearchmarkmackeysusanatomasi-140624094318-phpapp01
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Tue, 24 Jun 2014 09:43:18 GMT /slideshow/comparing-the-electrostatic-properties-of-protein-active-sites-and-other-cresset-research/36246243 cressetgroup@slideshare.net(cressetgroup) Comparing the electrostatic properties of protein active sites and other cresset research cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/comparingtheelectrostaticpropertiesofproteinactivesitesandothercressetresearchmarkmackeysusanatomasi-140624094318-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Comparing the electrostatic properties of protein active sites and other cresset research from Cresset
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Torch for medicinal chemists /slideshow/torch-for-medicinal-chemists/36246016 torchformedicinalchemiststimcheeseright-140624093717-phpapp02
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Tue, 24 Jun 2014 09:37:17 GMT /slideshow/torch-for-medicinal-chemists/36246016 cressetgroup@slideshare.net(cressetgroup) Torch for medicinal chemists cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/torchformedicinalchemiststimcheeseright-140624093717-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Torch for medicinal chemists from Cresset
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Discovery and optimization of novel small molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacementCocklin cresset user group meeting 2014 /slideshow/discovery-and-optimization-of-novel-small-molecule-hiv1-entry-inhibitors-using-fieldbased-virtual-screening-and-bioisosteric-replacementcocklin-cresset-user-group-meeting-2014/36243980 cocklin-cressetusergroupmeeting2014-140624085343-phpapp01
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Tue, 24 Jun 2014 08:53:43 GMT /slideshow/discovery-and-optimization-of-novel-small-molecule-hiv1-entry-inhibitors-using-fieldbased-virtual-screening-and-bioisosteric-replacementcocklin-cresset-user-group-meeting-2014/36243980 cressetgroup@slideshare.net(cressetgroup) Discovery and optimization of novel small molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacementCocklin cresset user group meeting 2014 cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/cocklin-cressetusergroupmeeting2014-140624085343-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Discovery and optimization of novel small molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacementCocklin cresset user group meeting 2014 from Cresset
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Smart drug re profiling using computational chemistry tools novel biology and pharmacological insights /slideshow/smart-drug-re-profiling-using-computational-chemistry-tools-novel-biology-and-pharmacological-insights/34568971 smartdrugre-profilingusingcomputationalchemistrytoolsnovelbiologyandpharmacologicalinsights-140512090805-phpapp01
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Mon, 12 May 2014 09:08:04 GMT /slideshow/smart-drug-re-profiling-using-computational-chemistry-tools-novel-biology-and-pharmacological-insights/34568971 cressetgroup@slideshare.net(cressetgroup) Smart drug re profiling using computational chemistry tools novel biology and pharmacological insights cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/smartdrugre-profilingusingcomputationalchemistrytoolsnovelbiologyandpharmacologicalinsights-140512090805-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Smart drug re profiling using computational chemistry tools novel biology and pharmacological insights from Cresset
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Matched molecular pair and activity cliffs published /slideshow/matched-molecular-pair-and-activity-cliffs-published/32754767 matchedmolecularpairandactivitycliffspublished-140326061842-phpapp02
In this presentation I present our research into using 3D methods to detect and interpret activity cliffs using Activity Miner. I will show that considering the shape and especially the electrostatic environment around a pair of molecules results in a richer more informed view of the factors causing changes in activity and a hypothesis driven understanding of existing SAR.]]>

In this presentation I present our research into using 3D methods to detect and interpret activity cliffs using Activity Miner. I will show that considering the shape and especially the electrostatic environment around a pair of molecules results in a richer more informed view of the factors causing changes in activity and a hypothesis driven understanding of existing SAR.]]>
Wed, 26 Mar 2014 06:18:42 GMT /slideshow/matched-molecular-pair-and-activity-cliffs-published/32754767 cressetgroup@slideshare.net(cressetgroup) Matched molecular pair and activity cliffs published cressetgroup In this presentation I present our research into using 3D methods to detect and interpret activity cliffs using Activity Miner. I will show that considering the shape and especially the electrostatic environment around a pair of molecules results in a richer more informed view of the factors causing changes in activity and a hypothesis driven understanding of existing SAR. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/matchedmolecularpairandactivitycliffspublished-140326061842-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> In this presentation I present our research into using 3D methods to detect and interpret activity cliffs using Activity Miner. I will show that considering the shape and especially the electrostatic environment around a pair of molecules results in a richer more informed view of the factors causing changes in activity and a hypothesis driven understanding of existing SAR.
Matched molecular pair and activity cliffs published from Cresset
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Intelligent library design for protein families and beyond sp /cressetgroup/intelligent-library-design-for-protein-families-and-beyond-sp-32397589 intelligentlibrarydesignforproteinfamiliesandbeyondsp-140317081119-phpapp01
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Mon, 17 Mar 2014 08:11:19 GMT /cressetgroup/intelligent-library-design-for-protein-families-and-beyond-sp-32397589 cressetgroup@slideshare.net(cressetgroup) Intelligent library design for protein families and beyond sp cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/intelligentlibrarydesignforproteinfamiliesandbeyondsp-140317081119-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Intelligent library design for protein families and beyond sp from Cresset
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Intelligent library design for protein families and beyond sp /slideshow/intelligent-library-design-for-protein-families-and-beyond-sp/31929688 intelligentlibrarydesignforproteinfamiliesandbeyondsp-140305024148-phpapp02
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Wed, 05 Mar 2014 02:41:48 GMT /slideshow/intelligent-library-design-for-protein-families-and-beyond-sp/31929688 cressetgroup@slideshare.net(cressetgroup) Intelligent library design for protein families and beyond sp cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/intelligentlibrarydesignforproteinfamiliesandbeyondsp-140305024148-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Intelligent library design for protein families and beyond sp from Cresset
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Finding and using activity cliffs in 3D: Gaining more SAR information during lead optimization /slideshow/finding-and-using-activity-cliffs-in-3d-gaining-more-sar-information-during-lead-optimization/26166493 mdmacssep2013sp-130913075358-phpapp02
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Fri, 13 Sep 2013 07:53:58 GMT /slideshow/finding-and-using-activity-cliffs-in-3d-gaining-more-sar-information-during-lead-optimization/26166493 cressetgroup@slideshare.net(cressetgroup) Finding and using activity cliffs in 3D: Gaining more SAR information during lead optimization cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/mdmacssep2013sp-130913075358-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Finding and using activity cliffs in 3D: Gaining more SAR information during lead optimization from Cresset
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Tim Cheeseright, Assessing the Similarities of Compound collections using molecular fields: Does it add value? /cressetgroup/tim-cheeseright tcheeserightacsmar2012-120508105548-phpapp01
This presentation, originally given at the 2012 ACS National Meeting in San Diego, investigates alternative methods of defining chemical space using 3D Field based methodologies - the advantages and disadvantages of which are described.]]>

This presentation, originally given at the 2012 ACS National Meeting in San Diego, investigates alternative methods of defining chemical space using 3D Field based methodologies - the advantages and disadvantages of which are described.]]>
Tue, 08 May 2012 10:55:47 GMT /cressetgroup/tim-cheeseright cressetgroup@slideshare.net(cressetgroup) Tim Cheeseright, Assessing the Similarities of Compound collections using molecular fields: Does it add value? cressetgroup This presentation, originally given at the 2012 ACS National Meeting in San Diego, investigates alternative methods of defining chemical space using 3D Field based methodologies - the advantages and disadvantages of which are described. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/tcheeserightacsmar2012-120508105548-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> This presentation, originally given at the 2012 ACS National Meeting in San Diego, investigates alternative methods of defining chemical space using 3D Field based methodologies - the advantages and disadvantages of which are described.
Tim Cheeseright, Assessing the Similarities of Compound collections using molecular fields: Does it add value? from Cresset
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David Evans, Eli-Lilly, 'Field-Aligned Matched Pairs' /cressetgroup/david-evans-elililly-fieldaligned-matched-pairs-9727449 daecressetugm-111017030938-phpapp01
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Mon, 17 Oct 2011 03:09:36 GMT /cressetgroup/david-evans-elililly-fieldaligned-matched-pairs-9727449 cressetgroup@slideshare.net(cressetgroup) David Evans, Eli-Lilly, 'Field-Aligned Matched Pairs' cressetgroup <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/daecressetugm-111017030938-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
David Evans, Eli-Lilly, 'Field-Aligned Matched Pairs' from Cresset
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Cresset: 25 year of Fields /slideshow/cresset-25-year-of-fields/9642473 25yearoffields-111011053619-phpapp01
Mark Mackey takes a humourous look at Cresset's origins and the lessons we had to learn to get where we are today.]]>

Mark Mackey takes a humourous look at Cresset's origins and the lessons we had to learn to get where we are today.]]>
Tue, 11 Oct 2011 05:36:16 GMT /slideshow/cresset-25-year-of-fields/9642473 cressetgroup@slideshare.net(cressetgroup) Cresset: 25 year of Fields cressetgroup Mark Mackey takes a humourous look at Cresset's origins and the lessons we had to learn to get where we are today. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/25yearoffields-111011053619-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Mark Mackey takes a humourous look at Cresset&#39;s origins and the lessons we had to learn to get where we are today.
Cresset: 25 year of Fields from Cresset
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https://cdn.slidesharecdn.com/profile-photo-cressetgroup-48x48.jpg?cb=1523149833 Cresset makes chemistry software that enables biologically meaningful comparisons of molecules, without the limitations of 2D structure. www.cresset-group.com https://cdn.slidesharecdn.com/ss_thumbnails/iccs-activitycliffsaspresentedfbcemartinslater-140625030912-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/selectivity-mining-multiple-activities-in-activity-miner/36279244 Selectivity mining – m... https://cdn.slidesharecdn.com/ss_thumbnails/cocklin-cressetusergroupmeeting2014-140624104502-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/discovery-and-optimization-of-novel-small-molecule-hiv1-entry-inhibitors-using-fieldbased-virtual-screening-and-bioisosteric-replacement/36249147 Discovery and optimiza... https://cdn.slidesharecdn.com/ss_thumbnails/fieldbasedchemistryspring2014barr-140624104253-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/can-field-based-chemistry-help-us-to-predict-proteindna-binding-sites/36249060 Can field based chemis...