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Thu, 22 Nov 2018 13:22:36 GMT狠狠撸Share feed for 狠狠撸shows by User: mahbubalam78advanced drug delivery system of miconazole nitrate
/slideshow/advanced-drug-delivery-system-of-miconazole-nitrate/123708804
mahbubliosome-181122132236 A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane.
Liposomes were first described by British hematologist Dr. Alec.
LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.
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A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane.
Liposomes were first described by British hematologist Dr. Alec.
LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.
]]>
Thu, 22 Nov 2018 13:22:36 GMT/slideshow/advanced-drug-delivery-system-of-miconazole-nitrate/123708804mahbubalam78@slideshare.net(mahbubalam78)advanced drug delivery system of miconazole nitratemahbubalam78A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane.
Liposomes were first described by British hematologist Dr. Alec.
LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.
<img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/mahbubliosome-181122132236-thumbnail.jpg?width=120&height=120&fit=bounds" /><br> A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane.
Liposomes were first described by British hematologist Dr. Alec.
LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.
]]>
6381https://cdn.slidesharecdn.com/ss_thumbnails/mahbubliosome-181122132236-thumbnail.jpg?width=120&height=120&fit=boundspresentationBlackhttp://activitystrea.ms/schema/1.0/posthttp://activitystrea.ms/schema/1.0/posted0Atorvastatin mahbub
/slideshow/atorvastatin-mahbub-81886301/81886301
atorvastatinmahbub-171111074338 Introduction
Generic Name: Atorvastatin
Brand Names: Lipitor,Atorvast,Divastin,Lipicut
Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins."
Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL.
4Mechanism of action
Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body
5Pharmacokinetics
Absorption
Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1鈥�2 h
Distribution
The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk.
8Metabolism
Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation.
9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h.
10Medical Uses
Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels.
Hypertriglyceridemia
Primary prevention of heart attack, stroke.
Secondary prevention of myocardial infarction, stroke, unstable angina.
Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions
Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage.
Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy.
Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin.
12Precautions to be taken Before taking this medicine
Liver disease
Muscle pain or weakness
History of liver disease
History of kidney disease
History of stroke
If you are pregnant or breast-feeding
A thyroid disorder
If you drink more than 2 alcoholic beverages daily.
Side Effects
Cough
Difficulty with swallowing
Fast heartbeat
Fever and dizziness
Itching
Muscle cramps, pain, stiffness, swelling, or weakness
Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
Skin rash
Tightness in the chest
Unusual tiredness or weakness
]]>
Introduction
Generic Name: Atorvastatin
Brand Names: Lipitor,Atorvast,Divastin,Lipicut
Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins."
Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL.
4Mechanism of action
Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body
5Pharmacokinetics
Absorption
Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1鈥�2 h
Distribution
The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk.
8Metabolism
Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation.
9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h.
10Medical Uses
Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels.
Hypertriglyceridemia
Primary prevention of heart attack, stroke.
Secondary prevention of myocardial infarction, stroke, unstable angina.
Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions
Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage.
Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy.
Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin.
12Precautions to be taken Before taking this medicine
Liver disease
Muscle pain or weakness
History of liver disease
History of kidney disease
History of stroke
If you are pregnant or breast-feeding
A thyroid disorder
If you drink more than 2 alcoholic beverages daily.
Side Effects
Cough
Difficulty with swallowing
Fast heartbeat
Fever and dizziness
Itching
Muscle cramps, pain, stiffness, swelling, or weakness
Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
Skin rash
Tightness in the chest
Unusual tiredness or weakness
]]>
Sat, 11 Nov 2017 07:43:38 GMT/slideshow/atorvastatin-mahbub-81886301/81886301mahbubalam78@slideshare.net(mahbubalam78)Atorvastatin mahbubmahbubalam78Introduction
Generic Name: Atorvastatin
Brand Names: Lipitor,Atorvast,Divastin,Lipicut
Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins."
Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL.
4Mechanism of action
Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body
5Pharmacokinetics
Absorption
Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1鈥�2 h
Distribution
The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk.
8Metabolism
Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation.
9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h.
10Medical Uses
Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels.
Hypertriglyceridemia
Primary prevention of heart attack, stroke.
Secondary prevention of myocardial infarction, stroke, unstable angina.
Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions
Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage.
Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy.
Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin.
12Precautions to be taken Before taking this medicine
Liver disease
Muscle pain or weakness
History of liver disease
History of kidney disease
History of stroke
If you are pregnant or breast-feeding
A thyroid disorder
If you drink more than 2 alcoholic beverages daily.
Side Effects
Cough
Difficulty with swallowing
Fast heartbeat
Fever and dizziness
Itching
Muscle cramps, pain, stiffness, swelling, or weakness
Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
Skin rash
Tightness in the chest
Unusual tiredness or weakness
<img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/atorvastatinmahbub-171111074338-thumbnail.jpg?width=120&height=120&fit=bounds" /><br> Introduction
Generic Name: Atorvastatin
Brand Names: Lipitor,Atorvast,Divastin,Lipicut
Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins."
Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL.
4Mechanism of action
Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body
5Pharmacokinetics
Absorption
Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1鈥�2 h
Distribution
The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk.
8Metabolism
Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation.
9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h.
10Medical Uses
Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels.
Hypertriglyceridemia
Primary prevention of heart attack, stroke.
Secondary prevention of myocardial infarction, stroke, unstable angina.
Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions
Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage.
Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy.
Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin.
12Precautions to be taken Before taking this medicine
Liver disease
Muscle pain or weakness
History of liver disease
History of kidney disease
History of stroke
If you are pregnant or breast-feeding
A thyroid disorder
If you drink more than 2 alcoholic beverages daily.
Side Effects
Cough
Difficulty with swallowing
Fast heartbeat
Fever and dizziness
Itching
Muscle cramps, pain, stiffness, swelling, or weakness
Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
Skin rash
Tightness in the chest
Unusual tiredness or weakness
]]>
39162https://cdn.slidesharecdn.com/ss_thumbnails/atorvastatinmahbub-171111074338-thumbnail.jpg?width=120&height=120&fit=boundspresentationBlackhttp://activitystrea.ms/schema/1.0/posthttp://activitystrea.ms/schema/1.0/posted0https://public.slidesharecdn.com/v2/images/profile-picture.pnghttps://cdn.slidesharecdn.com/ss_thumbnails/mahbubliosome-181122132236-thumbnail.jpg?width=320&height=320&fit=boundsslideshow/advanced-drug-delivery-system-of-miconazole-nitrate/123708804advanced drug delivery...https://cdn.slidesharecdn.com/ss_thumbnails/atorvastatinmahbub-171111074338-thumbnail.jpg?width=320&height=320&fit=boundsslideshow/atorvastatin-mahbub-81886301/81886301Atorvastatin mahbub