�ݺ�ߣshows by User: mahbubalam78

�ݺ�ߣshows by User: mahbubalam78 / http://www.slideshare.net/images/logo.gif �ݺ�ߣshows by User: mahbubalam78 / Thu, 22 Nov 2018 13:22:36 GMT �ݺ�ߣShare feed for �ݺ�ߣshows by User: mahbubalam78 advanced drug delivery system of miconazole nitrate /slideshow/advanced-drug-delivery-system-of-miconazole-nitrate/123708804 mahbubliosome-181122132236
A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes were first described by British hematologist Dr. Alec. LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid. ]]>
A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes were first described by British hematologist Dr. Alec. LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid. ]]> Thu, 22 Nov 2018 13:22:36 GMT /slideshow/advanced-drug-delivery-system-of-miconazole-nitrate/123708804 mahbubalam78@slideshare.net(mahbubalam78) advanced drug delivery system of miconazole nitrate mahbubalam78 A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes were first described by British hematologist Dr. Alec. LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/mahbubliosome-181122132236-thumbnail.jpg?width=120&height=120&fit=bounds" /><br> A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes were first described by British hematologist Dr. Alec. LIPOSOME derives from two Greek words: lipo("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.

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0 Atorvastatin mahbub /slideshow/atorvastatin-mahbub-81886301/81886301 atorvastatinmahbub-171111074338
Introduction Generic Name: Atorvastatin Brand Names: Lipitor,Atorvast,Divastin,Lipicut Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL. 4Mechanism of action Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body 5Pharmacokinetics Absorption Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1–2 h Distribution The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk. 8Metabolism Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation. 9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h. 10Medical Uses Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels. Hypertriglyceridemia Primary prevention of heart attack, stroke. Secondary prevention of myocardial infarction, stroke, unstable angina. Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage. Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy. Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. 12Precautions to be taken Before taking this medicine Liver disease Muscle pain or weakness History of liver disease History of kidney disease History of stroke If you are pregnant or breast-feeding A thyroid disorder If you drink more than 2 alcoholic beverages daily. Side Effects Cough Difficulty with swallowing Fast heartbeat Fever and dizziness Itching Muscle cramps, pain, stiffness, swelling, or weakness Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Skin rash Tightness in the chest Unusual tiredness or weakness ]]>
Introduction Generic Name: Atorvastatin Brand Names: Lipitor,Atorvast,Divastin,Lipicut Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL. 4Mechanism of action Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body 5Pharmacokinetics Absorption Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1–2 h Distribution The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk. 8Metabolism Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation. 9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h. 10Medical Uses Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels. Hypertriglyceridemia Primary prevention of heart attack, stroke. Secondary prevention of myocardial infarction, stroke, unstable angina. Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage. Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy. Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. 12Precautions to be taken Before taking this medicine Liver disease Muscle pain or weakness History of liver disease History of kidney disease History of stroke If you are pregnant or breast-feeding A thyroid disorder If you drink more than 2 alcoholic beverages daily. Side Effects Cough Difficulty with swallowing Fast heartbeat Fever and dizziness Itching Muscle cramps, pain, stiffness, swelling, or weakness Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Skin rash Tightness in the chest Unusual tiredness or weakness ]]> Sat, 11 Nov 2017 07:43:38 GMT /slideshow/atorvastatin-mahbub-81886301/81886301 mahbubalam78@slideshare.net(mahbubalam78) Atorvastatin mahbub mahbubalam78 Introduction Generic Name: Atorvastatin Brand Names: Lipitor,Atorvast,Divastin,Lipicut Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL. 4Mechanism of action Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body 5Pharmacokinetics Absorption Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1–2 h Distribution The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk. 8Metabolism Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation. 9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h. 10Medical Uses Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels. Hypertriglyceridemia Primary prevention of heart attack, stroke. Secondary prevention of myocardial infarction, stroke, unstable angina. Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage. Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy. Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. 12Precautions to be taken Before taking this medicine Liver disease Muscle pain or weakness History of liver disease History of kidney disease History of stroke If you are pregnant or breast-feeding A thyroid disorder If you drink more than 2 alcoholic beverages daily. Side Effects Cough Difficulty with swallowing Fast heartbeat Fever and dizziness Itching Muscle cramps, pain, stiffness, swelling, or weakness Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Skin rash Tightness in the chest Unusual tiredness or weakness <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/atorvastatinmahbub-171111074338-thumbnail.jpg?width=120&height=120&fit=bounds" /><br> Introduction Generic Name: Atorvastatin Brand Names: Lipitor,Atorvast,Divastin,Lipicut Atorvastatin a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol or LDL and triglycerides in the blood, and also increasing levels of "good" cholesterol or HDL. 4Mechanism of action Statin drugs competitively inhibit HMG-CoA, which is an enzyme that catalyzes the synthesis of HMG-CoA in to cholesterol. Therefore, it effectively the synthesis of new cholesterol. It leads to an increase in LDL receptor on Liver cells to take in more LDL, effectively decreasing LDL in the body 5Pharmacokinetics Absorption Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration of 1–2 h Distribution The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (=98%), and likely secreted into human breast milk. 8Metabolism Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho-and parahydroxylatedmetabolites. The ortho-and parahydroxylatedmetabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxymetabolite undergoes further metabolism via glucuronidation. 9ExcretionAtorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepaticmetabolism. Atorvastatin has an approximate elimination half-life of 14 h. 10Medical Uses Hypercholesterolemia to reduce total cholesterol, LDL-C, apo-B, as well as increase HDL levels. Hypertriglyceridemia Primary prevention of heart attack, stroke. Secondary prevention of myocardial infarction, stroke, unstable angina. Myocardial infarction and stroke prophylaxis in patients with type II diabetesInteractions Grapefruit juice can increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage. Interactions with clofibrate, fenofibrate, gemfibrozil, usually in combination with statins, increase the risk of myopathy. Barbiturates, carbamazepine, oxcarbazepine, rifampin, and rifamycin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. 12Precautions to be taken Before taking this medicine Liver disease Muscle pain or weakness History of liver disease History of kidney disease History of stroke If you are pregnant or breast-feeding A thyroid disorder If you drink more than 2 alcoholic beverages daily. Side Effects Cough Difficulty with swallowing Fast heartbeat Fever and dizziness Itching Muscle cramps, pain, stiffness, swelling, or weakness Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Skin rash Tightness in the chest Unusual tiredness or weakness

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0 https://public.slidesharecdn.com/v2/images/profile-picture.png https://cdn.slidesharecdn.com/ss_thumbnails/mahbubliosome-181122132236-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/advanced-drug-delivery-system-of-miconazole-nitrate/123708804 advanced drug delivery... https://cdn.slidesharecdn.com/ss_thumbnails/atorvastatinmahbub-171111074338-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/atorvastatin-mahbub-81886301/81886301 Atorvastatin mahbub