ºÝºÝߣshows by User: nkz02 / http://www.slideshare.net/images/logo.gif ºÝºÝߣshows by User: nkz02 / Sat, 03 Aug 2013 20:31:08 GMT ºÝºÝߣShare feed for ºÝºÝߣshows by User: nkz02 The Effect of Atorvastatin (Lipitor) on the Duration of Survival of Allogeneic Skin Graft and the Growth of B16F10 Melanoma Cells in Mice /slideshow/effect-of-lipitor-on-graft-survival-tumor-growth-24903021/24903021 effectoflipitorongraftsurvivaltumorgrowth-130803203108-phpapp02
Aim: To evaluate the immunomodulatory effect of using non-cholesterol lowering dose of atorvastatin (AS) on skin allograft survival and on tumor growth in mice. Study Design: Experimental Study. Place and Duration of Study: Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut; 2011-2012. Methodology: BALB/c mice were transplanted with skin allografts from C57BL/6 mice and given either AS alone or in combination with immunosuppressive agents. Average survival days of skin allografts were recorded and serum levels of interleukin-1β (IL-1β) and interferon-γ (IFN-γ) were quantified. BALB/c mice and C57BL/6 mice were challenged intraperitoneally with B16F10 melanoma cancer cells (cancer cell line syngeneic to C57BL/6 mice) and were then treated with AS. They were observed regularly for tumor growth. Results: The results indicated that in transplant mice AS given alone or in combination with immunosuppressive agents prolonged allograft survival time through noncholesterol lowering mechanisms in spite of a non-significant change in serum cytokine levels. Furthermore, AS treatment enhanced tumor growth in C57BL/6 mice and promoted tumor growth in BALB/C mice. Conclusion: It can be speculated that AS down expresses TLR and modifies MHC presentation resulting in hindering the generation of an innate and adaptive immune response.]]>
Aim: To evaluate the immunomodulatory effect of using non-cholesterol lowering dose of atorvastatin (AS) on skin allograft survival and on tumor growth in mice. Study Design: Experimental Study. Place and Duration of Study: Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut; 2011-2012. Methodology: BALB/c mice were transplanted with skin allografts from C57BL/6 mice and given either AS alone or in combination with immunosuppressive agents. Average survival days of skin allografts were recorded and serum levels of interleukin-1β (IL-1β) and interferon-γ (IFN-γ) were quantified. BALB/c mice and C57BL/6 mice were challenged intraperitoneally with B16F10 melanoma cancer cells (cancer cell line syngeneic to C57BL/6 mice) and were then treated with AS. They were observed regularly for tumor growth. Results: The results indicated that in transplant mice AS given alone or in combination with immunosuppressive agents prolonged allograft survival time through noncholesterol lowering mechanisms in spite of a non-significant change in serum cytokine levels. Furthermore, AS treatment enhanced tumor growth in C57BL/6 mice and promoted tumor growth in BALB/C mice. Conclusion: It can be speculated that AS down expresses TLR and modifies MHC presentation resulting in hindering the generation of an innate and adaptive immune response.]]> Sat, 03 Aug 2013 20:31:08 GMT /slideshow/effect-of-lipitor-on-graft-survival-tumor-growth-24903021/24903021 nkz02@slideshare.net(nkz02) The Effect of Atorvastatin (Lipitor) on the Duration of Survival of Allogeneic Skin Graft and the Growth of B16F10 Melanoma Cells in Mice nkz02 Aim: To evaluate the immunomodulatory effect of using non-cholesterol lowering dose of atorvastatin (AS) on skin allograft survival and on tumor growth in mice. Study Design: Experimental Study. Place and Duration of Study: Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut; 2011-2012. Methodology: BALB/c mice were transplanted with skin allografts from C57BL/6 mice and given either AS alone or in combination with immunosuppressive agents. Average survival days of skin allografts were recorded and serum levels of interleukin-1β (IL-1β) and interferon-γ (IFN-γ) were quantified. BALB/c mice and C57BL/6 mice were challenged intraperitoneally with B16F10 melanoma cancer cells (cancer cell line syngeneic to C57BL/6 mice) and were then treated with AS. They were observed regularly for tumor growth. Results: The results indicated that in transplant mice AS given alone or in combination with immunosuppressive agents prolonged allograft survival time through noncholesterol lowering mechanisms in spite of a non-significant change in serum cytokine levels. Furthermore, AS treatment enhanced tumor growth in C57BL/6 mice and promoted tumor growth in BALB/C mice. Conclusion: It can be speculated that AS down expresses TLR and modifies MHC presentation resulting in hindering the generation of an innate and adaptive immune response. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/effectoflipitorongraftsurvivaltumorgrowth-130803203108-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Aim: To evaluate the immunomodulatory effect of using non-cholesterol lowering dose of atorvastatin (AS) on skin allograft survival and on tumor growth in mice. Study Design: Experimental Study. Place and Duration of Study: Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut; 2011-2012. Methodology: BALB/c mice were transplanted with skin allografts from C57BL/6 mice and given either AS alone or in combination with immunosuppressive agents. Average survival days of skin allografts were recorded and serum levels of interleukin-1β (IL-1β) and interferon-γ (IFN-γ) were quantified. BALB/c mice and C57BL/6 mice were challenged intraperitoneally with B16F10 melanoma cancer cells (cancer cell line syngeneic to C57BL/6 mice) and were then treated with AS. They were observed regularly for tumor growth. Results: The results indicated that in transplant mice AS given alone or in combination with immunosuppressive agents prolonged allograft survival time through noncholesterol lowering mechanisms in spite of a non-significant change in serum cytokine levels. Furthermore, AS treatment enhanced tumor growth in C57BL/6 mice and promoted tumor growth in BALB/C mice. Conclusion: It can be speculated that AS down expresses TLR and modifies MHC presentation resulting in hindering the generation of an innate and adaptive immune response.
The Effect of Atorvastatin (Lipitor) on the Duration of Survival of Allogeneic Skin Graft and the Growth of B16F10 Melanoma Cells in Mice from Nabil Zeidan
]]> 823 4 https://cdn.slidesharecdn.com/ss_thumbnails/effectoflipitorongraftsurvivaltumorgrowth-130803203108-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds document White http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Bma statins and transplantation /slideshow/bma-statins-and-transplantation/24481703 bmastatinsandtransplantation-130721215520-phpapp01
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]]> Sun, 21 Jul 2013 21:55:20 GMT /slideshow/bma-statins-and-transplantation/24481703 nkz02@slideshare.net(nkz02) Bma statins and transplantation nkz02 <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/bmastatinsandtransplantation-130721215520-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Bma statins and transplantation from Nabil Zeidan
]]> 504 4 https://cdn.slidesharecdn.com/ss_thumbnails/bmastatinsandtransplantation-130721215520-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-nkz02-48x48.jpg?cb=1612977321 Specialties: Immunology, Tumor Immunology, Immune Regulation & Microbiology https://cdn.slidesharecdn.com/ss_thumbnails/effectoflipitorongraftsurvivaltumorgrowth-130803203108-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/effect-of-lipitor-on-graft-survival-tumor-growth-24903021/24903021 The Effect of Atorvast... https://cdn.slidesharecdn.com/ss_thumbnails/bmastatinsandtransplantation-130721215520-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/bma-statins-and-transplantation/24481703 Bma statins and transp...