ºÝºÝߣshows by User: organprinter / http://www.slideshare.net/images/logo.gif ºÝºÝߣshows by User: organprinter / Mon, 18 Jan 2010 01:48:22 GMT ºÝºÝߣShare feed for ºÝºÝߣshows by User: organprinter Booking Your Bandin Texas Austin /slideshow/booking-your-bandin-texas-austin/2938557 bookingyourbandintexas-austin-100118014830-phpapp02
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Mon, 18 Jan 2010 01:48:22 GMT /slideshow/booking-your-bandin-texas-austin/2938557 organprinter@slideshare.net(organprinter) Booking Your Bandin Texas Austin organprinter <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/bookingyourbandintexas-austin-100118014830-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Booking Your Bandin Texas Austin from Matthew Wettergreen
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Materials Of Storage /slideshow/materials-of-storage/2089125 materialsofstorage-090929082622-phpapp02
Lecture for Week 6 of ENGI/HUMA 240: Engineering Design for Art and Artifact Conservation]]>

Lecture for Week 6 of ENGI/HUMA 240: Engineering Design for Art and Artifact Conservation]]>
Tue, 29 Sep 2009 08:26:19 GMT /slideshow/materials-of-storage/2089125 organprinter@slideshare.net(organprinter) Materials Of Storage organprinter Lecture for Week 6 of ENGI/HUMA 240: Engineering Design for Art and Artifact Conservation <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/materialsofstorage-090929082622-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Lecture for Week 6 of ENGI/HUMA 240: Engineering Design for Art and Artifact Conservation
Materials Of Storage from Matthew Wettergreen
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Environmental Systems for Art Storage /organprinter/environmental-systems-for-art-storage environmentalsystems-090929082152-phpapp01
Lecture for ENGI/HUMA 240: Environmental Controls for Art Storage]]>

Lecture for ENGI/HUMA 240: Environmental Controls for Art Storage]]>
Tue, 29 Sep 2009 08:21:47 GMT /organprinter/environmental-systems-for-art-storage organprinter@slideshare.net(organprinter) Environmental Systems for Art Storage organprinter Lecture for ENGI/HUMA 240: Environmental Controls for Art Storage <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/environmentalsystems-090929082152-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Lecture for ENGI/HUMA 240: Environmental Controls for Art Storage
Environmental Systems for Art Storage from Matthew Wettergreen
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Storage And Transportation Of Art Objects /slideshow/storage-and-transportation-of-art-objects/2082792 storageandtransportationofartobjects-090928114022-phpapp02
Lecture on Art Storage and Transportation for ENGI/HUMA 240: Engineering for Art Conservation]]>

Lecture on Art Storage and Transportation for ENGI/HUMA 240: Engineering for Art Conservation]]>
Mon, 28 Sep 2009 11:40:11 GMT /slideshow/storage-and-transportation-of-art-objects/2082792 organprinter@slideshare.net(organprinter) Storage And Transportation Of Art Objects organprinter Lecture on Art Storage and Transportation for ENGI/HUMA 240: Engineering for Art Conservation <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/storageandtransportationofartobjects-090928114022-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Lecture on Art Storage and Transportation for ENGI/HUMA 240: Engineering for Art Conservation
Storage And Transportation Of Art Objects from Matthew Wettergreen
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Digital Workflow /slideshow/digital-workflow/1916704 digitalworkflow-090827162155-phpapp01
Rice University Fall '09 Course: ENGI/HUMA 240 Engineering and Design for Art Conservation. Lecture 2: Digital Workflow]]>

Rice University Fall '09 Course: ENGI/HUMA 240 Engineering and Design for Art Conservation. Lecture 2: Digital Workflow]]>
Thu, 27 Aug 2009 16:21:44 GMT /slideshow/digital-workflow/1916704 organprinter@slideshare.net(organprinter) Digital Workflow organprinter Rice University Fall '09 Course: ENGI/HUMA 240 Engineering and Design for Art Conservation. Lecture 2: Digital Workflow <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/digitalworkflow-090827162155-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Rice University Fall &#39;09 Course: ENGI/HUMA 240 Engineering and Design for Art Conservation. Lecture 2: Digital Workflow
Digital Workflow from Matthew Wettergreen
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Engineering and Design for Art Conservation: Course Introduction /slideshow/engineering-and-design-for-art-conservation-course-introduction/1907151 courseintroduction-090826013915-phpapp02
Course overview for Rice University course entitled Engineering and Design for Art Conservation. http://edaac.rice.edu]]>

Course overview for Rice University course entitled Engineering and Design for Art Conservation. http://edaac.rice.edu]]>
Wed, 26 Aug 2009 01:39:06 GMT /slideshow/engineering-and-design-for-art-conservation-course-introduction/1907151 organprinter@slideshare.net(organprinter) Engineering and Design for Art Conservation: Course Introduction organprinter Course overview for Rice University course entitled Engineering and Design for Art Conservation. http://edaac.rice.edu <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/courseintroduction-090826013915-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Course overview for Rice University course entitled Engineering and Design for Art Conservation. http://edaac.rice.edu
Engineering and Design for Art Conservation: Course Introduction from Matthew Wettergreen
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MAW Thesis /organprinter/maw-thesis-presentation thesisver40finalformatted-1222969446907924-8
Thesis presented by Matthew Wettergreen on April 16th, 2008 as the final requirement for the degree of Doctor of Philosophy]]>

Thesis presented by Matthew Wettergreen on April 16th, 2008 as the final requirement for the degree of Doctor of Philosophy]]>
Thu, 02 Oct 2008 10:52:05 GMT /organprinter/maw-thesis-presentation organprinter@slideshare.net(organprinter) MAW Thesis organprinter Thesis presented by Matthew Wettergreen on April 16th, 2008 as the final requirement for the degree of Doctor of Philosophy <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/thesisver40finalformatted-1222969446907924-8-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Thesis presented by Matthew Wettergreen on April 16th, 2008 as the final requirement for the degree of Doctor of Philosophy
MAW Thesis from Matthew Wettergreen
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Design and Characterization of Cellular Solids from Modeling through Solid Freeform Fabrication, 8/2006 /slideshow/design-and-characterization-of-cellular-solids-from-modeling-through-solid-freeform-fabrication-82006-presentation/625964 sff2006wettergreen-1222743456965824-8
Presentation given to the Solid Freeform Fabrication Conference, Austin, TX 8/2006 ABSTRACT Cellular solids studies the mechanical effects of the material arrangement of architectures for the goal of designing materials which are lightweight and possess high structural integrity. These architectures present themselves frequently in structural members in nature (bone, plant stalks, and porous rock) and are now used frequently in design (tissue engineering scaffolds, mechanical design). Until now however, physical studies of these architectures have been completed using molding techniques (for 2D) and random models (for 3D). Rapid prototyping (RP) provides high repeatability during replication which decreases error in studied samples and can serve to reduce the number of conflicting variables which confound the development of structural relationships. In this study we designed and characterized four geometric solids from the Platonic and Archimedean set of polyhedra, the simplest architectures that exist in nature which exhibit symmetry and order. Multiple models of these polyhedra were generated using computer aided design at similar topologies but with varying volume fractions. Employing finite element analysis we analyzed the structures with simulated uni-axial linear compressive tests. We then built actual models of the architectures using solid laser sintering (SLS) with a Sinterstation 2500Plus. The architectures were printed at porosities of 80% and 90% by volume with a bounding box of 2cm x 2cm x 2cm. After printing of the models, they were scanned with micro-computed tomography (µCT) as a validation of the use of SLS for fabrication of computer modeled architectures. Finally, the architectures were compressed to fracture using an MTS, validating the modeling component of the design and providing information which will allow for the determination of relationships which govern the material arrangement and resulting mechanical properties. These results of this study are useful in the development of models which directly relate complex architecture to mechanical properties; these models can be used to develop any architecture based on given input parameters such as porosity, surface area, connectivity and fracture pattern.]]>

Presentation given to the Solid Freeform Fabrication Conference, Austin, TX 8/2006 ABSTRACT Cellular solids studies the mechanical effects of the material arrangement of architectures for the goal of designing materials which are lightweight and possess high structural integrity. These architectures present themselves frequently in structural members in nature (bone, plant stalks, and porous rock) and are now used frequently in design (tissue engineering scaffolds, mechanical design). Until now however, physical studies of these architectures have been completed using molding techniques (for 2D) and random models (for 3D). Rapid prototyping (RP) provides high repeatability during replication which decreases error in studied samples and can serve to reduce the number of conflicting variables which confound the development of structural relationships. In this study we designed and characterized four geometric solids from the Platonic and Archimedean set of polyhedra, the simplest architectures that exist in nature which exhibit symmetry and order. Multiple models of these polyhedra were generated using computer aided design at similar topologies but with varying volume fractions. Employing finite element analysis we analyzed the structures with simulated uni-axial linear compressive tests. We then built actual models of the architectures using solid laser sintering (SLS) with a Sinterstation 2500Plus. The architectures were printed at porosities of 80% and 90% by volume with a bounding box of 2cm x 2cm x 2cm. After printing of the models, they were scanned with micro-computed tomography (µCT) as a validation of the use of SLS for fabrication of computer modeled architectures. Finally, the architectures were compressed to fracture using an MTS, validating the modeling component of the design and providing information which will allow for the determination of relationships which govern the material arrangement and resulting mechanical properties. These results of this study are useful in the development of models which directly relate complex architecture to mechanical properties; these models can be used to develop any architecture based on given input parameters such as porosity, surface area, connectivity and fracture pattern.]]>
Mon, 29 Sep 2008 20:04:48 GMT /slideshow/design-and-characterization-of-cellular-solids-from-modeling-through-solid-freeform-fabrication-82006-presentation/625964 organprinter@slideshare.net(organprinter) Design and Characterization of Cellular Solids from Modeling through Solid Freeform Fabrication, 8/2006 organprinter Presentation given to the Solid Freeform Fabrication Conference, Austin, TX 8/2006 ABSTRACT Cellular solids studies the mechanical effects of the material arrangement of architectures for the goal of designing materials which are lightweight and possess high structural integrity. These architectures present themselves frequently in structural members in nature (bone, plant stalks, and porous rock) and are now used frequently in design (tissue engineering scaffolds, mechanical design). Until now however, physical studies of these architectures have been completed using molding techniques (for 2D) and random models (for 3D). Rapid prototyping (RP) provides high repeatability during replication which decreases error in studied samples and can serve to reduce the number of conflicting variables which confound the development of structural relationships. In this study we designed and characterized four geometric solids from the Platonic and Archimedean set of polyhedra, the simplest architectures that exist in nature which exhibit symmetry and order. Multiple models of these polyhedra were generated using computer aided design at similar topologies but with varying volume fractions. Employing finite element analysis we analyzed the structures with simulated uni-axial linear compressive tests. We then built actual models of the architectures using solid laser sintering (SLS) with a Sinterstation 2500Plus. The architectures were printed at porosities of 80% and 90% by volume with a bounding box of 2cm x 2cm x 2cm. After printing of the models, they were scanned with micro-computed tomography (µCT) as a validation of the use of SLS for fabrication of computer modeled architectures. Finally, the architectures were compressed to fracture using an MTS, validating the modeling component of the design and providing information which will allow for the determination of relationships which govern the material arrangement and resulting mechanical properties. These results of this study are useful in the development of models which directly relate complex architecture to mechanical properties; these models can be used to develop any architecture based on given input parameters such as porosity, surface area, connectivity and fracture pattern. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/sff2006wettergreen-1222743456965824-8-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Presentation given to the Solid Freeform Fabrication Conference, Austin, TX 8/2006 ABSTRACT Cellular solids studies the mechanical effects of the material arrangement of architectures for the goal of designing materials which are lightweight and possess high structural integrity. These architectures present themselves frequently in structural members in nature (bone, plant stalks, and porous rock) and are now used frequently in design (tissue engineering scaffolds, mechanical design). Until now however, physical studies of these architectures have been completed using molding techniques (for 2D) and random models (for 3D). Rapid prototyping (RP) provides high repeatability during replication which decreases error in studied samples and can serve to reduce the number of conflicting variables which confound the development of structural relationships. In this study we designed and characterized four geometric solids from the Platonic and Archimedean set of polyhedra, the simplest architectures that exist in nature which exhibit symmetry and order. Multiple models of these polyhedra were generated using computer aided design at similar topologies but with varying volume fractions. Employing finite element analysis we analyzed the structures with simulated uni-axial linear compressive tests. We then built actual models of the architectures using solid laser sintering (SLS) with a Sinterstation 2500Plus. The architectures were printed at porosities of 80% and 90% by volume with a bounding box of 2cm x 2cm x 2cm. After printing of the models, they were scanned with micro-computed tomography (µCT) as a validation of the use of SLS for fabrication of computer modeled architectures. Finally, the architectures were compressed to fracture using an MTS, validating the modeling component of the design and providing information which will allow for the determination of relationships which govern the material arrangement and resulting mechanical properties. These results of this study are useful in the development of models which directly relate complex architecture to mechanical properties; these models can be used to develop any architecture based on given input parameters such as porosity, surface area, connectivity and fracture pattern.
Design and Characterization of Cellular Solids from Modeling through Solid Freeform Fabrication, 8/2006 from Matthew Wettergreen
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Poster: Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping, 10/2004 /organprinter/tailoring-the-mechanical-environment-of-scaffolds-with-computer-aided-design-and-rapid-prototyping-102004-presentation 2004wettergreenbmes-1222731431737607-8
ABSTRACT Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping Wettergreen MA, Bucklen BS, Mikos AG, Liebschner MAK Department of Bioengineering, Rice University, Houston, TX 77005 While porous scaffolds have shown success in stimulating tissue growth, the random organization of the microarchitecture results in regions exhibiting large variability in mechanical properties. Stress profiles on the scaffold surface depend upon the volume fraction and may vary wildly, presenting regions, which may be unsuitable for cell attachment and viability. If a regular/repeatable architecture is provided, the mechanical environment can be predetermined. We and others have previously demonstrated that rapid prototyping can be utilized to create scaffolds with designed, repeated architecture. The goal of this study was to evaluate a library of CAD designed architectures for tissue engineering. Regular polyhedra based on the Archimedean and Platonic solids and architectures taken from current literature were compared against randomized architecture using finite element analysis. The results demonstrated that for a specific material volume fraction but varying spatial distribution, Young’s Modulus may vary by two orders of magnitude, thus illustrating the dependence of strength upon architecture. Additionally, the stress profile for the designed architectures exhibit peaks at specific stress levels and scaffolds with grossly dissimilar geometry exhibited similar stress profiles. Scaffolds with tailored mechanical properties may be assembled from the unit architectures. The scaffolds may be fabricated from any desired material using rapid prototyping and negative molding and may be helpful for treating defects which require the scaffold to bear mechanical loading.]]>

ABSTRACT Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping Wettergreen MA, Bucklen BS, Mikos AG, Liebschner MAK Department of Bioengineering, Rice University, Houston, TX 77005 While porous scaffolds have shown success in stimulating tissue growth, the random organization of the microarchitecture results in regions exhibiting large variability in mechanical properties. Stress profiles on the scaffold surface depend upon the volume fraction and may vary wildly, presenting regions, which may be unsuitable for cell attachment and viability. If a regular/repeatable architecture is provided, the mechanical environment can be predetermined. We and others have previously demonstrated that rapid prototyping can be utilized to create scaffolds with designed, repeated architecture. The goal of this study was to evaluate a library of CAD designed architectures for tissue engineering. Regular polyhedra based on the Archimedean and Platonic solids and architectures taken from current literature were compared against randomized architecture using finite element analysis. The results demonstrated that for a specific material volume fraction but varying spatial distribution, Young’s Modulus may vary by two orders of magnitude, thus illustrating the dependence of strength upon architecture. Additionally, the stress profile for the designed architectures exhibit peaks at specific stress levels and scaffolds with grossly dissimilar geometry exhibited similar stress profiles. Scaffolds with tailored mechanical properties may be assembled from the unit architectures. The scaffolds may be fabricated from any desired material using rapid prototyping and negative molding and may be helpful for treating defects which require the scaffold to bear mechanical loading.]]>
Mon, 29 Sep 2008 16:44:48 GMT /organprinter/tailoring-the-mechanical-environment-of-scaffolds-with-computer-aided-design-and-rapid-prototyping-102004-presentation organprinter@slideshare.net(organprinter) Poster: Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping, 10/2004 organprinter ABSTRACT Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping Wettergreen MA, Bucklen BS, Mikos AG, Liebschner MAK Department of Bioengineering, Rice University, Houston, TX 77005 While porous scaffolds have shown success in stimulating tissue growth, the random organization of the microarchitecture results in regions exhibiting large variability in mechanical properties. Stress profiles on the scaffold surface depend upon the volume fraction and may vary wildly, presenting regions, which may be unsuitable for cell attachment and viability. If a regular/repeatable architecture is provided, the mechanical environment can be predetermined. We and others have previously demonstrated that rapid prototyping can be utilized to create scaffolds with designed, repeated architecture. The goal of this study was to evaluate a library of CAD designed architectures for tissue engineering. Regular polyhedra based on the Archimedean and Platonic solids and architectures taken from current literature were compared against randomized architecture using finite element analysis. The results demonstrated that for a specific material volume fraction but varying spatial distribution, Young’s Modulus may vary by two orders of magnitude, thus illustrating the dependence of strength upon architecture. Additionally, the stress profile for the designed architectures exhibit peaks at specific stress levels and scaffolds with grossly dissimilar geometry exhibited similar stress profiles. Scaffolds with tailored mechanical properties may be assembled from the unit architectures. The scaffolds may be fabricated from any desired material using rapid prototyping and negative molding and may be helpful for treating defects which require the scaffold to bear mechanical loading. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/2004wettergreenbmes-1222731431737607-8-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> ABSTRACT Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping Wettergreen MA, Bucklen BS, Mikos AG, Liebschner MAK Department of Bioengineering, Rice University, Houston, TX 77005 While porous scaffolds have shown success in stimulating tissue growth, the random organization of the microarchitecture results in regions exhibiting large variability in mechanical properties. Stress profiles on the scaffold surface depend upon the volume fraction and may vary wildly, presenting regions, which may be unsuitable for cell attachment and viability. If a regular/repeatable architecture is provided, the mechanical environment can be predetermined. We and others have previously demonstrated that rapid prototyping can be utilized to create scaffolds with designed, repeated architecture. The goal of this study was to evaluate a library of CAD designed architectures for tissue engineering. Regular polyhedra based on the Archimedean and Platonic solids and architectures taken from current literature were compared against randomized architecture using finite element analysis. The results demonstrated that for a specific material volume fraction but varying spatial distribution, Young’s Modulus may vary by two orders of magnitude, thus illustrating the dependence of strength upon architecture. Additionally, the stress profile for the designed architectures exhibit peaks at specific stress levels and scaffolds with grossly dissimilar geometry exhibited similar stress profiles. Scaffolds with tailored mechanical properties may be assembled from the unit architectures. The scaffolds may be fabricated from any desired material using rapid prototyping and negative molding and may be helpful for treating defects which require the scaffold to bear mechanical loading.
Poster: Tailoring the Mechanical Environment of Scaffolds with Computer Aided Design and Rapid Prototyping, 10/2004 from Matthew Wettergreen
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Optimization Of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering, 06/2004 /slideshow/optimization-of-scaffold-regeneration-process-using-negative-templates-created-using-computer-aided-tissue-engineering-062004-presentation/595735 psrcear2-1221252515685073-9
Presentation given at the Plastic Surgery Research Council, June 2004 ABSTRACT Optimization Of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering]]>

Presentation given at the Plastic Surgery Research Council, June 2004 ABSTRACT Optimization Of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering]]>
Fri, 12 Sep 2008 13:52:29 GMT /slideshow/optimization-of-scaffold-regeneration-process-using-negative-templates-created-using-computer-aided-tissue-engineering-062004-presentation/595735 organprinter@slideshare.net(organprinter) Optimization Of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering, 06/2004 organprinter Presentation given at the Plastic Surgery Research Council, June 2004 ABSTRACT Optimization Of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/psrcear2-1221252515685073-9-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Presentation given at the Plastic Surgery Research Council, June 2004 ABSTRACT Optimization Of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering
Optimization Of Scaffold Regeneration Process Using Negative Templates Created Using Computer Aided Tissue Engineering, 06/2004 from Matthew Wettergreen
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Tissue Engineered Composite Bone Cement For Reinforcing Osteoporotic Bone, 4/2003 /slideshow/tissue-engineered-composite-bone-cement-for-reinforcing-osteoporotic-bone-42003-presentation/581281 wettergreenhsembmodified-1220465241350274-8
ABSTRACT Tissue Engineered Composite Bone Cement For Reinforcing Osteoporotic Bone Matthew Wettergreen, Michael A.K. Liebschner Department of Bioengineering, Rice University, Houston, TX INTRODUCTION: Injectable materials for use in vertebroblasty and kyphoplasty have been augmented with micro- or nano- sized particles to increase the overall mechanical strength of the composite material. These studies have focused solely on the improvement of the mechanical properties through the adjustment of geometry, architecture, and degradation profile of the material. The goal of the current study was the generation of a porous material, with a controlled rate of degradation, which can be used for injection purposes. MATERIALS AND METHODS: By focusing on the engineering of an interconnected pore structure, a high surface area to volume ratio can be created, increasing the strength of the material while maintaining porosity. A novel injectable bone cement is created using a Calcium Phosphate slurry with solid phase polypropylene fumarate (PPF) particulates of engineered architecture. The PPF is formed into macrosize (~750um) two-dimensional star-like shapes using rapid prototyping technology and molding processes. The star shape is designed to seal the spaces between adjacent trabeculae, which have a spacing of approximately 1mm. Plugging of the inter-trabecular spacing should aid in the containment of the liquid bone cement during injection, preventing the common problem of overfilling. RESULTS AND CONCLUSION: The optimal volume percent and +/-10% volume percent of PPF is introduced into the viscous material to create the injectable composite. The three formulations are then injected into cylindrical volumes for testing purposes. After curing, the samples are scanned on a µCT 80 (Scanco Medical, Basserdorf, Switzerland) with a resolution of 10um. Incorporation of a contrast agent will allow the visualization of each phase of the composite material using µCT. The scans will be used to evaluate the interconnected void spaces formed when the PPF degrades. A degradation study is performed to evaluate the degradation of the PPF micro-particles. Degraded samples will be mechanically tested to evaluate whether degradation of the microparticles reduces the mechanical strength of the cements to levels insufficient for usage in vertebroblasty and kyphoplasty. By using a composite material consisting of a liquid element phase, an ordered pore structure can be generated. The cured material may promote bone growth and could ultimately improve the biomechanical quality of the regenerated trabecular bone in a vertebral body after treatment. The incorporation of geometric shapes and regulated architecture into liquid injectable materials could be used in vertebroblasty and kyphoplasty for reinforcement or bone fracture repair.]]>

ABSTRACT Tissue Engineered Composite Bone Cement For Reinforcing Osteoporotic Bone Matthew Wettergreen, Michael A.K. Liebschner Department of Bioengineering, Rice University, Houston, TX INTRODUCTION: Injectable materials for use in vertebroblasty and kyphoplasty have been augmented with micro- or nano- sized particles to increase the overall mechanical strength of the composite material. These studies have focused solely on the improvement of the mechanical properties through the adjustment of geometry, architecture, and degradation profile of the material. The goal of the current study was the generation of a porous material, with a controlled rate of degradation, which can be used for injection purposes. MATERIALS AND METHODS: By focusing on the engineering of an interconnected pore structure, a high surface area to volume ratio can be created, increasing the strength of the material while maintaining porosity. A novel injectable bone cement is created using a Calcium Phosphate slurry with solid phase polypropylene fumarate (PPF) particulates of engineered architecture. The PPF is formed into macrosize (~750um) two-dimensional star-like shapes using rapid prototyping technology and molding processes. The star shape is designed to seal the spaces between adjacent trabeculae, which have a spacing of approximately 1mm. Plugging of the inter-trabecular spacing should aid in the containment of the liquid bone cement during injection, preventing the common problem of overfilling. RESULTS AND CONCLUSION: The optimal volume percent and +/-10% volume percent of PPF is introduced into the viscous material to create the injectable composite. The three formulations are then injected into cylindrical volumes for testing purposes. After curing, the samples are scanned on a µCT 80 (Scanco Medical, Basserdorf, Switzerland) with a resolution of 10um. Incorporation of a contrast agent will allow the visualization of each phase of the composite material using µCT. The scans will be used to evaluate the interconnected void spaces formed when the PPF degrades. A degradation study is performed to evaluate the degradation of the PPF micro-particles. Degraded samples will be mechanically tested to evaluate whether degradation of the microparticles reduces the mechanical strength of the cements to levels insufficient for usage in vertebroblasty and kyphoplasty. By using a composite material consisting of a liquid element phase, an ordered pore structure can be generated. The cured material may promote bone growth and could ultimately improve the biomechanical quality of the regenerated trabecular bone in a vertebral body after treatment. The incorporation of geometric shapes and regulated architecture into liquid injectable materials could be used in vertebroblasty and kyphoplasty for reinforcement or bone fracture repair.]]>
Wed, 03 Sep 2008 11:08:19 GMT /slideshow/tissue-engineered-composite-bone-cement-for-reinforcing-osteoporotic-bone-42003-presentation/581281 organprinter@slideshare.net(organprinter) Tissue Engineered Composite Bone Cement For Reinforcing Osteoporotic Bone, 4/2003 organprinter ABSTRACT Tissue Engineered Composite Bone Cement For Reinforcing Osteoporotic Bone Matthew Wettergreen, Michael A.K. Liebschner Department of Bioengineering, Rice University, Houston, TX INTRODUCTION: Injectable materials for use in vertebroblasty and kyphoplasty have been augmented with micro- or nano- sized particles to increase the overall mechanical strength of the composite material. These studies have focused solely on the improvement of the mechanical properties through the adjustment of geometry, architecture, and degradation profile of the material. The goal of the current study was the generation of a porous material, with a controlled rate of degradation, which can be used for injection purposes. MATERIALS AND METHODS: By focusing on the engineering of an interconnected pore structure, a high surface area to volume ratio can be created, increasing the strength of the material while maintaining porosity. A novel injectable bone cement is created using a Calcium Phosphate slurry with solid phase polypropylene fumarate (PPF) particulates of engineered architecture. The PPF is formed into macrosize (~750um) two-dimensional star-like shapes using rapid prototyping technology and molding processes. The star shape is designed to seal the spaces between adjacent trabeculae, which have a spacing of approximately 1mm. Plugging of the inter-trabecular spacing should aid in the containment of the liquid bone cement during injection, preventing the common problem of overfilling. RESULTS AND CONCLUSION: The optimal volume percent and +/-10% volume percent of PPF is introduced into the viscous material to create the injectable composite. The three formulations are then injected into cylindrical volumes for testing purposes. After curing, the samples are scanned on a µCT 80 (Scanco Medical, Basserdorf, Switzerland) with a resolution of 10um. Incorporation of a contrast agent will allow the visualization of each phase of the composite material using µCT. The scans will be used to evaluate the interconnected void spaces formed when the PPF degrades. A degradation study is performed to evaluate the degradation of the PPF micro-particles. Degraded samples will be mechanically tested to evaluate whether degradation of the microparticles reduces the mechanical strength of the cements to levels insufficient for usage in vertebroblasty and kyphoplasty. By using a composite material consisting of a liquid element phase, an ordered pore structure can be generated. The cured material may promote bone growth and could ultimately improve the biomechanical quality of the regenerated trabecular bone in a vertebral body after treatment. The incorporation of geometric shapes and regulated architecture into liquid injectable materials could be used in vertebroblasty and kyphoplasty for reinforcement or bone fracture repair. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/wettergreenhsembmodified-1220465241350274-8-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> ABSTRACT Tissue Engineered Composite Bone Cement For Reinforcing Osteoporotic Bone Matthew Wettergreen, Michael A.K. Liebschner Department of Bioengineering, Rice University, Houston, TX INTRODUCTION: Injectable materials for use in vertebroblasty and kyphoplasty have been augmented with micro- or nano- sized particles to increase the overall mechanical strength of the composite material. These studies have focused solely on the improvement of the mechanical properties through the adjustment of geometry, architecture, and degradation profile of the material. The goal of the current study was the generation of a porous material, with a controlled rate of degradation, which can be used for injection purposes. MATERIALS AND METHODS: By focusing on the engineering of an interconnected pore structure, a high surface area to volume ratio can be created, increasing the strength of the material while maintaining porosity. A novel injectable bone cement is created using a Calcium Phosphate slurry with solid phase polypropylene fumarate (PPF) particulates of engineered architecture. The PPF is formed into macrosize (~750um) two-dimensional star-like shapes using rapid prototyping technology and molding processes. The star shape is designed to seal the spaces between adjacent trabeculae, which have a spacing of approximately 1mm. Plugging of the inter-trabecular spacing should aid in the containment of the liquid bone cement during injection, preventing the common problem of overfilling. RESULTS AND CONCLUSION: The optimal volume percent and +/-10% volume percent of PPF is introduced into the viscous material to create the injectable composite. The three formulations are then injected into cylindrical volumes for testing purposes. After curing, the samples are scanned on a µCT 80 (Scanco Medical, Basserdorf, Switzerland) with a resolution of 10um. Incorporation of a contrast agent will allow the visualization of each phase of the composite material using µCT. The scans will be used to evaluate the interconnected void spaces formed when the PPF degrades. A degradation study is performed to evaluate the degradation of the PPF micro-particles. Degraded samples will be mechanically tested to evaluate whether degradation of the microparticles reduces the mechanical strength of the cements to levels insufficient for usage in vertebroblasty and kyphoplasty. By using a composite material consisting of a liquid element phase, an ordered pore structure can be generated. The cured material may promote bone growth and could ultimately improve the biomechanical quality of the regenerated trabecular bone in a vertebral body after treatment. The incorporation of geometric shapes and regulated architecture into liquid injectable materials could be used in vertebroblasty and kyphoplasty for reinforcement or bone fracture repair.
Tissue Engineered Composite Bone Cement For Reinforcing Osteoporotic Bone, 4/2003 from Matthew Wettergreen
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Novel Bone Anchor Concept for Osteoporotic Bone Tissue, 02/2003 /slideshow/preors-bone-anchor-presentation/580404 preorswettergreen-1220415080760201-9
ABSTRACT During the past decade, the use of bone screws in spinal stabilization has dramatically increased. Failure of implanted screws to provide adequate stabilization can necessitate additional surgical procedures. Modifications of factors previously shown to be associated with increased screw pullout strength have shown to be insignificant when applied in osteoporotic bone. The objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance when compared to metal screws. We conducted a finite element study simulating implant pullout testing of a metal bone screw and a polymer bone anchor. The results indicated that the polymer bone anchor, while having inferior material properties, has superior biomechanical behavior. The pullout strength was increased by 40% with the new design, while stiffness was increased by more than four fold. We conclude from this study that bone anchors made out of polymers may be suitable for medical applications, however, their design needs to deviate from the traditional screw shape for adequate fixation. With material properties matching bone, polymers may prove to be more successful in long-term clinical applications, especially in osteoporotic bone. INTRODUCTION Surgical management of fractures has historically been accomplished by fixation of the fragments with metallic implants. Despite substantial improvements in metallurgy, design, and the understanding of the biomechanical forces acting on the implant system, the screw-bone interface has remained a major site of complications leading to failure of treatment [1]. Biomedical polymers with properties matching bone tissue may be a better alternative. The overall objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance in osteoporotic bone when compared to metal screws. In this first phase we conducted a finite element study simulating implant pullout testing of a metal bone screw and a new concept design using a polymer bone anchor. MATERIALS AND METHODS Three-dimensional finite element models of a trabecular bone core with a cortical shell, a metal bone screw, and a new bone anchor were developed. Finite element models were of standard single-threaded TSRH screws (Medtronics Sofamor Danek, Memphis, TN, U.S.A) with properties of titanium. The polymer bone anchor was designed with an orthogonal beam network mimicking trabecular bone with channels allowing even distribution of an injectable material between the implant and the adjacent bone tissue. Material properties of the anchor were based on published data for the biomaterial. Trabecular bone was modeled as transversely isotropic osteoporotic bone. The outer diameter of the bone core was more than three times the diameter of the implants. The pullout test was simulated with a max displacement of 2.25 mm. Stiffness and strength were calculated from the load-deformation curves. RESULTS Metal bone screws can be considered as the gold standard to stabilize spinal functional units. Therefore, we compared the biomechanical behavior in the other construct with the behavior of the bone screw. Our results indicate that the initial pullout resistance of the bone anchor is about four fold higher than that of the bone screw and the pullout-strength is about 40% higher in the bone anchor. CONCLUSION The bone-screw interface is a critical component for spinal stabilization. Placement of a significantly stiffer implant into bone disperses the forces non-uniformly, and regions of increased stress result within the screw and the bone. Weakened mechanical properties of synthetic polymers require a paradigm shift in the design of the screw. The much larger bone-implant interface of the new design lead to a drastically increased pullout strength (>40%) in osteoporotic bone when compared to the metal screw. The properties of the bone anchor]]>

ABSTRACT During the past decade, the use of bone screws in spinal stabilization has dramatically increased. Failure of implanted screws to provide adequate stabilization can necessitate additional surgical procedures. Modifications of factors previously shown to be associated with increased screw pullout strength have shown to be insignificant when applied in osteoporotic bone. The objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance when compared to metal screws. We conducted a finite element study simulating implant pullout testing of a metal bone screw and a polymer bone anchor. The results indicated that the polymer bone anchor, while having inferior material properties, has superior biomechanical behavior. The pullout strength was increased by 40% with the new design, while stiffness was increased by more than four fold. We conclude from this study that bone anchors made out of polymers may be suitable for medical applications, however, their design needs to deviate from the traditional screw shape for adequate fixation. With material properties matching bone, polymers may prove to be more successful in long-term clinical applications, especially in osteoporotic bone. INTRODUCTION Surgical management of fractures has historically been accomplished by fixation of the fragments with metallic implants. Despite substantial improvements in metallurgy, design, and the understanding of the biomechanical forces acting on the implant system, the screw-bone interface has remained a major site of complications leading to failure of treatment [1]. Biomedical polymers with properties matching bone tissue may be a better alternative. The overall objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance in osteoporotic bone when compared to metal screws. In this first phase we conducted a finite element study simulating implant pullout testing of a metal bone screw and a new concept design using a polymer bone anchor. MATERIALS AND METHODS Three-dimensional finite element models of a trabecular bone core with a cortical shell, a metal bone screw, and a new bone anchor were developed. Finite element models were of standard single-threaded TSRH screws (Medtronics Sofamor Danek, Memphis, TN, U.S.A) with properties of titanium. The polymer bone anchor was designed with an orthogonal beam network mimicking trabecular bone with channels allowing even distribution of an injectable material between the implant and the adjacent bone tissue. Material properties of the anchor were based on published data for the biomaterial. Trabecular bone was modeled as transversely isotropic osteoporotic bone. The outer diameter of the bone core was more than three times the diameter of the implants. The pullout test was simulated with a max displacement of 2.25 mm. Stiffness and strength were calculated from the load-deformation curves. RESULTS Metal bone screws can be considered as the gold standard to stabilize spinal functional units. Therefore, we compared the biomechanical behavior in the other construct with the behavior of the bone screw. Our results indicate that the initial pullout resistance of the bone anchor is about four fold higher than that of the bone screw and the pullout-strength is about 40% higher in the bone anchor. CONCLUSION The bone-screw interface is a critical component for spinal stabilization. Placement of a significantly stiffer implant into bone disperses the forces non-uniformly, and regions of increased stress result within the screw and the bone. Weakened mechanical properties of synthetic polymers require a paradigm shift in the design of the screw. The much larger bone-implant interface of the new design lead to a drastically increased pullout strength (>40%) in osteoporotic bone when compared to the metal screw. The properties of the bone anchor]]>
Tue, 02 Sep 2008 21:17:58 GMT /slideshow/preors-bone-anchor-presentation/580404 organprinter@slideshare.net(organprinter) Novel Bone Anchor Concept for Osteoporotic Bone Tissue, 02/2003 organprinter ABSTRACT During the past decade, the use of bone screws in spinal stabilization has dramatically increased. Failure of implanted screws to provide adequate stabilization can necessitate additional surgical procedures. Modifications of factors previously shown to be associated with increased screw pullout strength have shown to be insignificant when applied in osteoporotic bone. The objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance when compared to metal screws. We conducted a finite element study simulating implant pullout testing of a metal bone screw and a polymer bone anchor. The results indicated that the polymer bone anchor, while having inferior material properties, has superior biomechanical behavior. The pullout strength was increased by 40% with the new design, while stiffness was increased by more than four fold. We conclude from this study that bone anchors made out of polymers may be suitable for medical applications, however, their design needs to deviate from the traditional screw shape for adequate fixation. With material properties matching bone, polymers may prove to be more successful in long-term clinical applications, especially in osteoporotic bone. INTRODUCTION Surgical management of fractures has historically been accomplished by fixation of the fragments with metallic implants. Despite substantial improvements in metallurgy, design, and the understanding of the biomechanical forces acting on the implant system, the screw-bone interface has remained a major site of complications leading to failure of treatment [1]. Biomedical polymers with properties matching bone tissue may be a better alternative. The overall objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance in osteoporotic bone when compared to metal screws. In this first phase we conducted a finite element study simulating implant pullout testing of a metal bone screw and a new concept design using a polymer bone anchor. MATERIALS AND METHODS Three-dimensional finite element models of a trabecular bone core with a cortical shell, a metal bone screw, and a new bone anchor were developed. Finite element models were of standard single-threaded TSRH screws (Medtronics Sofamor Danek, Memphis, TN, U.S.A) with properties of titanium. The polymer bone anchor was designed with an orthogonal beam network mimicking trabecular bone with channels allowing even distribution of an injectable material between the implant and the adjacent bone tissue. Material properties of the anchor were based on published data for the biomaterial. Trabecular bone was modeled as transversely isotropic osteoporotic bone. The outer diameter of the bone core was more than three times the diameter of the implants. The pullout test was simulated with a max displacement of 2.25 mm. Stiffness and strength were calculated from the load-deformation curves. RESULTS Metal bone screws can be considered as the gold standard to stabilize spinal functional units. Therefore, we compared the biomechanical behavior in the other construct with the behavior of the bone screw. Our results indicate that the initial pullout resistance of the bone anchor is about four fold higher than that of the bone screw and the pullout-strength is about 40% higher in the bone anchor. CONCLUSION The bone-screw interface is a critical component for spinal stabilization. Placement of a significantly stiffer implant into bone disperses the forces non-uniformly, and regions of increased stress result within the screw and the bone. Weakened mechanical properties of synthetic polymers require a paradigm shift in the design of the screw. The much larger bone-implant interface of the new design lead to a drastically increased pullout strength (>40%) in osteoporotic bone when compared to the metal screw. The properties of the bone anchor <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/preorswettergreen-1220415080760201-9-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> ABSTRACT During the past decade, the use of bone screws in spinal stabilization has dramatically increased. Failure of implanted screws to provide adequate stabilization can necessitate additional surgical procedures. Modifications of factors previously shown to be associated with increased screw pullout strength have shown to be insignificant when applied in osteoporotic bone. The objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance when compared to metal screws. We conducted a finite element study simulating implant pullout testing of a metal bone screw and a polymer bone anchor. The results indicated that the polymer bone anchor, while having inferior material properties, has superior biomechanical behavior. The pullout strength was increased by 40% with the new design, while stiffness was increased by more than four fold. We conclude from this study that bone anchors made out of polymers may be suitable for medical applications, however, their design needs to deviate from the traditional screw shape for adequate fixation. With material properties matching bone, polymers may prove to be more successful in long-term clinical applications, especially in osteoporotic bone. INTRODUCTION Surgical management of fractures has historically been accomplished by fixation of the fragments with metallic implants. Despite substantial improvements in metallurgy, design, and the understanding of the biomechanical forces acting on the implant system, the screw-bone interface has remained a major site of complications leading to failure of treatment [1]. Biomedical polymers with properties matching bone tissue may be a better alternative. The overall objective of this study was to investigate the feasibility of a new bone anchor design in providing superior biomechanical performance in osteoporotic bone when compared to metal screws. In this first phase we conducted a finite element study simulating implant pullout testing of a metal bone screw and a new concept design using a polymer bone anchor. MATERIALS AND METHODS Three-dimensional finite element models of a trabecular bone core with a cortical shell, a metal bone screw, and a new bone anchor were developed. Finite element models were of standard single-threaded TSRH screws (Medtronics Sofamor Danek, Memphis, TN, U.S.A) with properties of titanium. The polymer bone anchor was designed with an orthogonal beam network mimicking trabecular bone with channels allowing even distribution of an injectable material between the implant and the adjacent bone tissue. Material properties of the anchor were based on published data for the biomaterial. Trabecular bone was modeled as transversely isotropic osteoporotic bone. The outer diameter of the bone core was more than three times the diameter of the implants. The pullout test was simulated with a max displacement of 2.25 mm. Stiffness and strength were calculated from the load-deformation curves. RESULTS Metal bone screws can be considered as the gold standard to stabilize spinal functional units. Therefore, we compared the biomechanical behavior in the other construct with the behavior of the bone screw. Our results indicate that the initial pullout resistance of the bone anchor is about four fold higher than that of the bone screw and the pullout-strength is about 40% higher in the bone anchor. CONCLUSION The bone-screw interface is a critical component for spinal stabilization. Placement of a significantly stiffer implant into bone disperses the forces non-uniformly, and regions of increased stress result within the screw and the bone. Weakened mechanical properties of synthetic polymers require a paradigm shift in the design of the screw. The much larger bone-implant interface of the new design lead to a drastically increased pullout strength (&gt;40%) in osteoporotic bone when compared to the metal screw. The properties of the bone anchor
Novel Bone Anchor Concept for Osteoporotic Bone Tissue, 02/2003 from Matthew Wettergreen
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Southern Biomedical Engineering Conference, 9/18/2002 /slideshow/southern-biomedical-engineering-conference-02918-presentation/580373 02918-sbmec-16modified-1220413531641714-8
Presentation made to the Southern Biomedical Engineering Conference in Bethesda, MD 9.18.02. An assessment of the importance of micro-environmental variation on resulting stress and strains levels at the microarchitecture of bone.]]>

Presentation made to the Southern Biomedical Engineering Conference in Bethesda, MD 9.18.02. An assessment of the importance of micro-environmental variation on resulting stress and strains levels at the microarchitecture of bone.]]>
Tue, 02 Sep 2008 20:49:58 GMT /slideshow/southern-biomedical-engineering-conference-02918-presentation/580373 organprinter@slideshare.net(organprinter) Southern Biomedical Engineering Conference, 9/18/2002 organprinter Presentation made to the Southern Biomedical Engineering Conference in Bethesda, MD 9.18.02. An assessment of the importance of micro-environmental variation on resulting stress and strains levels at the microarchitecture of bone. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/02918-sbmec-16modified-1220413531641714-8-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Presentation made to the Southern Biomedical Engineering Conference in Bethesda, MD 9.18.02. An assessment of the importance of micro-environmental variation on resulting stress and strains levels at the microarchitecture of bone.
Southern Biomedical Engineering Conference, 9/18/2002 from Matthew Wettergreen
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https://cdn.slidesharecdn.com/profile-photo-organprinter-48x48.jpg?cb=1659706076 Bioengineering PhD with computational implant design, rapid prototyping experience. Currently, Lecturer at Rice University teaching digital design/fabrication, visualization, physical prototyping, entrepreneurship, and mentoring engineering design teams. Previous life as the co-founder of Caroline Collective, Do713, and the designer of Record Monsters. Big on coworking, 3D printing, design, teaching, and meeting passionate people. Specialties: 3D Printing (formerly called Rapid Prototyping), Engineering Design Process, Information Design, Visualization, Product design, implant design, FEA modeling, CAD modeling, social media marketing, artist management, event production, live sound eng... matthewwettergreen.com https://cdn.slidesharecdn.com/ss_thumbnails/bookingyourbandintexas-austin-100118014830-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/booking-your-bandin-texas-austin/2938557 Booking Your Bandin Te... https://cdn.slidesharecdn.com/ss_thumbnails/materialsofstorage-090929082622-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/materials-of-storage/2089125 Materials Of Storage https://cdn.slidesharecdn.com/ss_thumbnails/environmentalsystems-090929082152-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds organprinter/environmental-systems-for-art-storage Environmental Systems ...