際際滷shows by User: parasietje1 / http://www.slideshare.net/images/logo.gif 際際滷shows by User: parasietje1 / Thu, 16 May 2019 08:58:44 GMT 際際滷Share feed for 際際滷shows by User: parasietje1 Model-informed precision dosing using non-linear mixed effects models: an identification or control problem? /parasietje1/modelinformed-precision-dosing-using-nonlinear-mixed-effects-models-an-identification-or-control-problem pmx-talk-presslideshare-190516085844
This slide deck introduces model-informed precision dosing to people with a basic education in PK/PD modeling. It explores some of the scientific challenges and proposed model-predictive control (MPC) as an alternative that may sidestep some of these challenges. Finally, we present an R package called `tdmore` to allow easy simulation of MIPD problems, and easy implementation of MIPD tools.]]>
This slide deck introduces model-informed precision dosing to people with a basic education in PK/PD modeling. It explores some of the scientific challenges and proposed model-predictive control (MPC) as an alternative that may sidestep some of these challenges. Finally, we present an R package called `tdmore` to allow easy simulation of MIPD problems, and easy implementation of MIPD tools.]]> Thu, 16 May 2019 08:58:44 GMT /parasietje1/modelinformed-precision-dosing-using-nonlinear-mixed-effects-models-an-identification-or-control-problem parasietje1@slideshare.net(parasietje1) Model-informed precision dosing using non-linear mixed effects models: an identification or control problem? parasietje1 This slide deck introduces model-informed precision dosing to people with a basic education in PK/PD modeling. It explores some of the scientific challenges and proposed model-predictive control (MPC) as an alternative that may sidestep some of these challenges. Finally, we present an R package called `tdmore` to allow easy simulation of MIPD problems, and easy implementation of MIPD tools. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/pmx-talk-presslideshare-190516085844-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> This slide deck introduces model-informed precision dosing to people with a basic education in PK/PD modeling. It explores some of the scientific challenges and proposed model-predictive control (MPC) as an alternative that may sidestep some of these challenges. Finally, we present an R package called `tdmore` to allow easy simulation of MIPD problems, and easy implementation of MIPD tools.
Model-informed precision dosing using non-linear mixed effects models: an identification or control problem? from Ruben Faelens
]]> 313 2 https://cdn.slidesharecdn.com/ss_thumbnails/pmx-talk-presslideshare-190516085844-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Clinical Trial Simulation training with simulo 20161124 /slideshow/clinical-trial-simulation-training-with-simulo-20161124/69532426 ctstrainingwithsimulo20161124nologin-161125173349
In collaboration with the University of Lyon, we presented a 2-hour session in Clinical Trial Simulation. This session fitted nicely within the Master's program curated by Emilie Henin (Calvagone). The 10 students managed to explore the PK model for Sunitinib. 4 students struck gold at the end, managing to create an efficient design that proved biosimilarity.]]>
In collaboration with the University of Lyon, we presented a 2-hour session in Clinical Trial Simulation. This session fitted nicely within the Master's program curated by Emilie Henin (Calvagone). The 10 students managed to explore the PK model for Sunitinib. 4 students struck gold at the end, managing to create an efficient design that proved biosimilarity.]]> Fri, 25 Nov 2016 17:33:49 GMT /slideshow/clinical-trial-simulation-training-with-simulo-20161124/69532426 parasietje1@slideshare.net(parasietje1) Clinical Trial Simulation training with simulo 20161124 parasietje1 In collaboration with the University of Lyon, we presented a 2-hour session in Clinical Trial Simulation. This session fitted nicely within the Master's program curated by Emilie Henin (Calvagone). The 10 students managed to explore the PK model for Sunitinib. 4 students struck gold at the end, managing to create an efficient design that proved biosimilarity. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/ctstrainingwithsimulo20161124nologin-161125173349-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> In collaboration with the University of Lyon, we presented a 2-hour session in Clinical Trial Simulation. This session fitted nicely within the Master&#39;s program curated by Emilie Henin (Calvagone). The 10 students managed to explore the PK model for Sunitinib. 4 students struck gold at the end, managing to create an efficient design that proved biosimilarity.
Clinical Trial Simulation training with simulo 20161124 from Ruben Faelens
]]> 501 6 https://cdn.slidesharecdn.com/ss_thumbnails/ctstrainingwithsimulo20161124nologin-161125173349-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 SGS Biopharm Day 2016 - Modeling & simulation in Phase 1 /parasietje1/sgs-biopharm-day-2016-modeling-simulation-in-phase-1 9-sgsantwerpseminar2016-rubenfaelens2016v3-161122134310
This slidedeck shows how Model-Informed Drug Development can be applied in a Phase 1 first-in-human trial, informing starting dose, dose escalation as well as stop dose.]]>
This slidedeck shows how Model-Informed Drug Development can be applied in a Phase 1 first-in-human trial, informing starting dose, dose escalation as well as stop dose.]]> Tue, 22 Nov 2016 13:43:10 GMT /parasietje1/sgs-biopharm-day-2016-modeling-simulation-in-phase-1 parasietje1@slideshare.net(parasietje1) SGS Biopharm Day 2016 - Modeling & simulation in Phase 1 parasietje1 This slidedeck shows how Model-Informed Drug Development can be applied in a Phase 1 first-in-human trial, informing starting dose, dose escalation as well as stop dose. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/9-sgsantwerpseminar2016-rubenfaelens2016v3-161122134310-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> This slidedeck shows how Model-Informed Drug Development can be applied in a Phase 1 first-in-human trial, informing starting dose, dose escalation as well as stop dose.
SGS Biopharm Day 2016 - Modeling & simulation in Phase 1 from Ruben Faelens
]]> 188 4 https://cdn.slidesharecdn.com/ss_thumbnails/9-sgsantwerpseminar2016-rubenfaelens2016v3-161122134310-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-parasietje1-48x48.jpg?cb=1557995924 Computer science engineer with +8 years experience in modeling & simulation. PhD research in nonlinear mixed effects modeling to calculate individualized doses. https://cdn.slidesharecdn.com/ss_thumbnails/pmx-talk-presslideshare-190516085844-thumbnail.jpg?width=320&height=320&fit=bounds parasietje1/modelinformed-precision-dosing-using-nonlinear-mixed-effects-models-an-identification-or-control-problem Model-informed precisi... https://cdn.slidesharecdn.com/ss_thumbnails/ctstrainingwithsimulo20161124nologin-161125173349-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/clinical-trial-simulation-training-with-simulo-20161124/69532426 Clinical Trial Simulat... https://cdn.slidesharecdn.com/ss_thumbnails/9-sgsantwerpseminar2016-rubenfaelens2016v3-161122134310-thumbnail.jpg?width=320&height=320&fit=bounds parasietje1/sgs-biopharm-day-2016-modeling-simulation-in-phase-1 SGS Biopharm Day 2016 ...