際際滷shows by User: profphilgale / http://www.slideshare.net/images/logo.gif 際際滷shows by User: profphilgale / Fri, 18 Jul 2014 03:25:36 GMT 際際滷Share feed for 際際滷shows by User: profphilgale Calixpyrrolepptx /slideshow/calixpyrrolepptx/37117671 calixpyrrolepptx-140718032536-phpapp02
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]]> Fri, 18 Jul 2014 03:25:36 GMT /slideshow/calixpyrrolepptx/37117671 profphilgale@slideshare.net(profphilgale) Calixpyrrolepptx profphilgale <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/calixpyrrolepptx-140718032536-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Calixpyrrolepptx from Philip Gale
]]> 566 2 https://cdn.slidesharecdn.com/ss_thumbnails/calixpyrrolepptx-140718032536-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Squaramides and thiosquaramides /slideshow/squaramides-and-thiosquaramides/36695797 squaramidesandthiosquaramides-140707045223-phpapp01
Squaramides and thiosquaramides are effective anion transporters. The transport properties of thiosquaramides can be switched by pH.]]>
Squaramides and thiosquaramides are effective anion transporters. The transport properties of thiosquaramides can be switched by pH.]]> Mon, 07 Jul 2014 04:52:23 GMT /slideshow/squaramides-and-thiosquaramides/36695797 profphilgale@slideshare.net(profphilgale) Squaramides and thiosquaramides profphilgale Squaramides and thiosquaramides are effective anion transporters. The transport properties of thiosquaramides can be switched by pH. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/squaramidesandthiosquaramides-140707045223-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Squaramides and thiosquaramides are effective anion transporters. The transport properties of thiosquaramides can be switched by pH.
Squaramides and thiosquaramides from Philip Gale
]]> 663 2 https://cdn.slidesharecdn.com/ss_thumbnails/squaramidesandthiosquaramides-140707045223-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Lipophilic balance /slideshow/lipophilic-balance/29969801 lipophilicbalance-140113131320-phpapp01
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]]> Mon, 13 Jan 2014 13:13:20 GMT /slideshow/lipophilic-balance/29969801 profphilgale@slideshare.net(profphilgale) Lipophilic balance profphilgale <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/lipophilicbalance-140113131320-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Lipophilic balance from Philip Gale
]]> 386 2 https://cdn.slidesharecdn.com/ss_thumbnails/lipophilicbalance-140113131320-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation White http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Sulfate transport /slideshow/sulfate-transport/29964185 sulfatetransport-140113103641-phpapp02
We report a new assay for transmembrane sulfate transport that has been used to show that small molecules can mediate the transport of this highly hydrophilic anion. See Chem. Sci. 2014, DOI: 10.1039/C3SC52006D]]>
We report a new assay for transmembrane sulfate transport that has been used to show that small molecules can mediate the transport of this highly hydrophilic anion. See Chem. Sci. 2014, DOI: 10.1039/C3SC52006D]]> Mon, 13 Jan 2014 10:36:41 GMT /slideshow/sulfate-transport/29964185 profphilgale@slideshare.net(profphilgale) Sulfate transport profphilgale We report a new assay for transmembrane sulfate transport that has been used to show that small molecules can mediate the transport of this highly hydrophilic anion. See Chem. Sci. 2014, DOI: 10.1039/C3SC52006D <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/sulfatetransport-140113103641-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> We report a new assay for transmembrane sulfate transport that has been used to show that small molecules can mediate the transport of this highly hydrophilic anion. See Chem. Sci. 2014, DOI: 10.1039/C3SC52006D
Sulfate transport from Philip Gale
]]> 613 2 https://cdn.slidesharecdn.com/ss_thumbnails/sulfatetransport-140113103641-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Towards Predictable Transmembrane Transport: QSAR Analysis of the Anion Binding and Anion Transport Properties of Thioureas /slideshow/qsar-29074245/29074245 qsar-131210084137-phpapp02
The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits of these compounds. However, little is known about the exact mechanism by which these drug-like molecules work and which molecular features make a good transporter. An extended series of 1-hexyl-3-phenylthioureas were synthesized, fully characterized (NMR, mass spectrometry, IR and single crystal diffraction) and their anion binding and anion transport properties were assessed using 1H NMR titration techniques and a variety of vesicle-based experiments. Quantitative structure-activity relationship (QSAR) analysis revealed that the anion binding abilities of the mono-thioureas are dominated by the (hydrogen bond) acidity of the thiourea NH function. Furthermore, mathematical models show that the experimental transmembrane anion transport ability is mainly dependent on the lipophilicity of the transporter (partitioning into the membrane), but smaller contributions of molecular size (diffusion) and hydrogen bond acidity (anion binding) were also present. Finally, we provide the first step towards predictable anion transport by employing the QSAR equations to estimate the transmembrane transport ability of four new compounds. ]]>
The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits of these compounds. However, little is known about the exact mechanism by which these drug-like molecules work and which molecular features make a good transporter. An extended series of 1-hexyl-3-phenylthioureas were synthesized, fully characterized (NMR, mass spectrometry, IR and single crystal diffraction) and their anion binding and anion transport properties were assessed using 1H NMR titration techniques and a variety of vesicle-based experiments. Quantitative structure-activity relationship (QSAR) analysis revealed that the anion binding abilities of the mono-thioureas are dominated by the (hydrogen bond) acidity of the thiourea NH function. Furthermore, mathematical models show that the experimental transmembrane anion transport ability is mainly dependent on the lipophilicity of the transporter (partitioning into the membrane), but smaller contributions of molecular size (diffusion) and hydrogen bond acidity (anion binding) were also present. Finally, we provide the first step towards predictable anion transport by employing the QSAR equations to estimate the transmembrane transport ability of four new compounds. ]]> Tue, 10 Dec 2013 08:41:37 GMT /slideshow/qsar-29074245/29074245 profphilgale@slideshare.net(profphilgale) Towards Predictable Transmembrane Transport: QSAR Analysis of the Anion Binding and Anion Transport Properties of Thioureas profphilgale The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits of these compounds. However, little is known about the exact mechanism by which these drug-like molecules work and which molecular features make a good transporter. An extended series of 1-hexyl-3-phenylthioureas were synthesized, fully characterized (NMR, mass spectrometry, IR and single crystal diffraction) and their anion binding and anion transport properties were assessed using 1H NMR titration techniques and a variety of vesicle-based experiments. Quantitative structure-activity relationship (QSAR) analysis revealed that the anion binding abilities of the mono-thioureas are dominated by the (hydrogen bond) acidity of the thiourea NH function. Furthermore, mathematical models show that the experimental transmembrane anion transport ability is mainly dependent on the lipophilicity of the transporter (partitioning into the membrane), but smaller contributions of molecular size (diffusion) and hydrogen bond acidity (anion binding) were also present. Finally, we provide the first step towards predictable anion transport by employing the QSAR equations to estimate the transmembrane transport ability of four new compounds. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/qsar-131210084137-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits of these compounds. However, little is known about the exact mechanism by which these drug-like molecules work and which molecular features make a good transporter. An extended series of 1-hexyl-3-phenylthioureas were synthesized, fully characterized (NMR, mass spectrometry, IR and single crystal diffraction) and their anion binding and anion transport properties were assessed using 1H NMR titration techniques and a variety of vesicle-based experiments. Quantitative structure-activity relationship (QSAR) analysis revealed that the anion binding abilities of the mono-thioureas are dominated by the (hydrogen bond) acidity of the thiourea NH function. Furthermore, mathematical models show that the experimental transmembrane anion transport ability is mainly dependent on the lipophilicity of the transporter (partitioning into the membrane), but smaller contributions of molecular size (diffusion) and hydrogen bond acidity (anion binding) were also present. Finally, we provide the first step towards predictable anion transport by employing the QSAR equations to estimate the transmembrane transport ability of four new compounds.
Towards Predictable Transmembrane Transport: QSAR Analysis of the Anion Binding and Anion Transport Properties of Thioureas from Philip Gale
]]> 1003 5 https://cdn.slidesharecdn.com/ss_thumbnails/qsar-131210084137-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-profphilgale-48x48.jpg?cb=1523729354 https://cdn.slidesharecdn.com/ss_thumbnails/calixpyrrolepptx-140718032536-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/calixpyrrolepptx/37117671 Calixpyrrolepptx https://cdn.slidesharecdn.com/ss_thumbnails/squaramidesandthiosquaramides-140707045223-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/squaramides-and-thiosquaramides/36695797 Squaramides and thiosq... https://cdn.slidesharecdn.com/ss_thumbnails/lipophilicbalance-140113131320-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/lipophilic-balance/29969801 Lipophilic balance