際際滷shows by User: runerasmussen1990 / http://www.slideshare.net/images/logo.gif 際際滷shows by User: runerasmussen1990 / Mon, 04 Nov 2013 08:03:48 GMT 際際滷Share feed for 際際滷shows by User: runerasmussen1990 Astrocytes in the Synapse: Nurse or Key-Player? /slideshow/astrocytes-in-the-synapse-nurse-or-keyplayer/27886221 presentation-131104080348-phpapp02
Astrocytes have for decades been considered as non-excitable support cells of the central nervous system (CNS). However, this view has changed radically during the last thirty years. Astrocytes have come to the forefront of neuroscience in our attempt to gain a better understanding of the cellular mechanisms underlying synaptic transmission. Astrocytes express a variety of surface receptors for common neurotransmitters, e.g., glutamate and acetylcholine. Additionally, astrocytes respond to stimulation by releasing gliotransmitters such as glutamate. These properties have led to the concept of tripartite synapse involving bidirectional communication between neurons and astrocytes. This review aims at summarizing current evidence for how astrocytes are involved in modulating synaptic transmission within cortical regions of the CNS. The activation of metabotropic- and ionotropic receptors expressed in astrocytes triggers an increase in their intracellular Ca2+ concentration, which in turn promotes the release of glutamate. The astrocyte released glutamate stimulate either group I or II and III metabotropic glutamate receptors (mGluRs) on presynaptic terminals. Depending on the type of activated presynaptic mGluR, astrocytic glutamate may either potentiate or depress synaptic transmission. In summary, astrocytes are actively participating in the modulation of synaptic transmission within cortical regions of the CNS. Astrocytes may consequently be a potential therapeutic target for brain pathological illnesses, e.g., neurodegeneration during ischemic stroke.]]>
Astrocytes have for decades been considered as non-excitable support cells of the central nervous system (CNS). However, this view has changed radically during the last thirty years. Astrocytes have come to the forefront of neuroscience in our attempt to gain a better understanding of the cellular mechanisms underlying synaptic transmission. Astrocytes express a variety of surface receptors for common neurotransmitters, e.g., glutamate and acetylcholine. Additionally, astrocytes respond to stimulation by releasing gliotransmitters such as glutamate. These properties have led to the concept of tripartite synapse involving bidirectional communication between neurons and astrocytes. This review aims at summarizing current evidence for how astrocytes are involved in modulating synaptic transmission within cortical regions of the CNS. The activation of metabotropic- and ionotropic receptors expressed in astrocytes triggers an increase in their intracellular Ca2+ concentration, which in turn promotes the release of glutamate. The astrocyte released glutamate stimulate either group I or II and III metabotropic glutamate receptors (mGluRs) on presynaptic terminals. Depending on the type of activated presynaptic mGluR, astrocytic glutamate may either potentiate or depress synaptic transmission. In summary, astrocytes are actively participating in the modulation of synaptic transmission within cortical regions of the CNS. Astrocytes may consequently be a potential therapeutic target for brain pathological illnesses, e.g., neurodegeneration during ischemic stroke.]]> Mon, 04 Nov 2013 08:03:48 GMT /slideshow/astrocytes-in-the-synapse-nurse-or-keyplayer/27886221 runerasmussen1990@slideshare.net(runerasmussen1990) Astrocytes in the Synapse: Nurse or Key-Player? runerasmussen1990 Astrocytes have for decades been considered as non-excitable support cells of the central nervous system (CNS). However, this view has changed radically during the last thirty years. Astrocytes have come to the forefront of neuroscience in our attempt to gain a better understanding of the cellular mechanisms underlying synaptic transmission. Astrocytes express a variety of surface receptors for common neurotransmitters, e.g., glutamate and acetylcholine. Additionally, astrocytes respond to stimulation by releasing gliotransmitters such as glutamate. These properties have led to the concept of tripartite synapse involving bidirectional communication between neurons and astrocytes. This review aims at summarizing current evidence for how astrocytes are involved in modulating synaptic transmission within cortical regions of the CNS. The activation of metabotropic- and ionotropic receptors expressed in astrocytes triggers an increase in their intracellular Ca2+ concentration, which in turn promotes the release of glutamate. The astrocyte released glutamate stimulate either group I or II and III metabotropic glutamate receptors (mGluRs) on presynaptic terminals. Depending on the type of activated presynaptic mGluR, astrocytic glutamate may either potentiate or depress synaptic transmission. In summary, astrocytes are actively participating in the modulation of synaptic transmission within cortical regions of the CNS. Astrocytes may consequently be a potential therapeutic target for brain pathological illnesses, e.g., neurodegeneration during ischemic stroke. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/presentation-131104080348-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Astrocytes have for decades been considered as non-excitable support cells of the central nervous system (CNS). However, this view has changed radically during the last thirty years. Astrocytes have come to the forefront of neuroscience in our attempt to gain a better understanding of the cellular mechanisms underlying synaptic transmission. Astrocytes express a variety of surface receptors for common neurotransmitters, e.g., glutamate and acetylcholine. Additionally, astrocytes respond to stimulation by releasing gliotransmitters such as glutamate. These properties have led to the concept of tripartite synapse involving bidirectional communication between neurons and astrocytes. This review aims at summarizing current evidence for how astrocytes are involved in modulating synaptic transmission within cortical regions of the CNS. The activation of metabotropic- and ionotropic receptors expressed in astrocytes triggers an increase in their intracellular Ca2+ concentration, which in turn promotes the release of glutamate. The astrocyte released glutamate stimulate either group I or II and III metabotropic glutamate receptors (mGluRs) on presynaptic terminals. Depending on the type of activated presynaptic mGluR, astrocytic glutamate may either potentiate or depress synaptic transmission. In summary, astrocytes are actively participating in the modulation of synaptic transmission within cortical regions of the CNS. Astrocytes may consequently be a potential therapeutic target for brain pathological illnesses, e.g., neurodegeneration during ischemic stroke.
Astrocytes in the Synapse: Nurse or Key-Player? from Rune Rasmussen
]]> 910 2 https://cdn.slidesharecdn.com/ss_thumbnails/presentation-131104080348-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Action potential propagation into the presynaptic dendrites of rat mitral cells /slideshow/presentation-rune/23659740 presentation-rune-130629101947-phpapp02
For my examination in the course Cellular Neuroscience at the University of Copenhagen I presented this classic paper by Bischofberger and Jonas (1997). ]]>
For my examination in the course Cellular Neuroscience at the University of Copenhagen I presented this classic paper by Bischofberger and Jonas (1997). ]]> Sat, 29 Jun 2013 10:19:46 GMT /slideshow/presentation-rune/23659740 runerasmussen1990@slideshare.net(runerasmussen1990) Action potential propagation into the presynaptic dendrites of rat mitral cells runerasmussen1990 For my examination in the course Cellular Neuroscience at the University of Copenhagen I presented this classic paper by Bischofberger and Jonas (1997). <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/presentation-rune-130629101947-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> For my examination in the course Cellular Neuroscience at the University of Copenhagen I presented this classic paper by Bischofberger and Jonas (1997).
Action potential propagation into the presynaptic dendrites of rat mitral cells from Rune Rasmussen
]]> 704 4 https://cdn.slidesharecdn.com/ss_thumbnails/presentation-rune-130629101947-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical /slideshow/presentation-ppt-23659237/23659237 presentationppt-130629100727-phpapp02
I was presenting this very elegant article by Wienisch and Klingauf (2006) in a course I completed this spring. ]]>
I was presenting this very elegant article by Wienisch and Klingauf (2006) in a course I completed this spring. ]]> Sat, 29 Jun 2013 10:07:27 GMT /slideshow/presentation-ppt-23659237/23659237 runerasmussen1990@slideshare.net(runerasmussen1990) Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical runerasmussen1990 I was presenting this very elegant article by Wienisch and Klingauf (2006) in a course I completed this spring. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/presentationppt-130629100727-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> I was presenting this very elegant article by Wienisch and Klingauf (2006) in a course I completed this spring.
Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical from Rune Rasmussen
]]> 709 2 https://cdn.slidesharecdn.com/ss_thumbnails/presentationppt-130629100727-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Bachelor's Defense /slideshow/bachelors-defense/23659078 badefence-english-130629100438-phpapp02
This presentation was for the defense of my Bachelor's degree thesis at the University of Copenhagen. ]]>
This presentation was for the defense of my Bachelor's degree thesis at the University of Copenhagen. ]]> Sat, 29 Jun 2013 10:04:38 GMT /slideshow/bachelors-defense/23659078 runerasmussen1990@slideshare.net(runerasmussen1990) Bachelor's Defense runerasmussen1990 This presentation was for the defense of my Bachelor's degree thesis at the University of Copenhagen. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/badefence-english-130629100438-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> This presentation was for the defense of my Bachelor&#39;s degree thesis at the University of Copenhagen.
Bachelor's Defense from Rune Rasmussen
]]> 5626 8 https://cdn.slidesharecdn.com/ss_thumbnails/badefence-english-130629100438-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-runerasmussen1990-48x48.jpg?cb=1523478704 I'm a young and driven M.Sc. student in Human Biology at the University of Copenhagen, with a particular interest within the scientific field of neuroscience. https://cdn.slidesharecdn.com/ss_thumbnails/presentation-131104080348-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/astrocytes-in-the-synapse-nurse-or-keyplayer/27886221 Astrocytes in the Syna... https://cdn.slidesharecdn.com/ss_thumbnails/presentation-rune-130629101947-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/presentation-rune/23659740 Action potential propa... https://cdn.slidesharecdn.com/ss_thumbnails/presentationppt-130629100727-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/presentation-ppt-23659237/23659237 Vesicular proteins exo...