ºÝºÝߣshows by User: sarafeltesse1 / http://www.slideshare.net/images/logo.gif ºÝºÝߣshows by User: sarafeltesse1 / Wed, 19 Nov 2014 15:08:03 GMT ºÝºÝߣShare feed for ºÝºÝߣshows by User: sarafeltesse1 Impact of novel ms ms all acquisition and processing techniques on forensic toxicological screening /slideshow/impact-of-novel-ms-ms-all-acquisition-and-processing-techniques-on-forensic-toxicological-screening/41773903 impactofnovelmsmsallacquisitionandprocessingtechniquesonforensictoxicologicalscreening-141119150803-conversion-gate02
Rapid forensic toxicology screening by high resolution mass spectrometry is a powerful technique. However, some compounds cannot be unambiguously identified with high resolution MS1 measurements alone. MS/MS fragmentation yields confident identifications of these compounds, but how to ensure quality MS/MS of these compounds? Data dependent techniques, although very powerful, cannot guarantee the measurement of all possible MS/MS candidates. Targeted MS/MS ensures acquisition of the target compounds, but limits the number of compounds. Data-independent techniques, such as SWATHâ„¢ acquisition (the MS/MS of all possible candidates), improve identifications significantly and enable retrospective analysis of the data. The impact of improvements to SWATH acquisition, including variable precursor window sizes, overlapping windows, and data processing were evaluated.]]>
Rapid forensic toxicology screening by high resolution mass spectrometry is a powerful technique. However, some compounds cannot be unambiguously identified with high resolution MS1 measurements alone. MS/MS fragmentation yields confident identifications of these compounds, but how to ensure quality MS/MS of these compounds? Data dependent techniques, although very powerful, cannot guarantee the measurement of all possible MS/MS candidates. Targeted MS/MS ensures acquisition of the target compounds, but limits the number of compounds. Data-independent techniques, such as SWATHâ„¢ acquisition (the MS/MS of all possible candidates), improve identifications significantly and enable retrospective analysis of the data. The impact of improvements to SWATH acquisition, including variable precursor window sizes, overlapping windows, and data processing were evaluated.]]> Wed, 19 Nov 2014 15:08:03 GMT /slideshow/impact-of-novel-ms-ms-all-acquisition-and-processing-techniques-on-forensic-toxicological-screening/41773903 sarafeltesse1@slideshare.net(sarafeltesse1) Impact of novel ms ms all acquisition and processing techniques on forensic toxicological screening sarafeltesse1 Rapid forensic toxicology screening by high resolution mass spectrometry is a powerful technique. However, some compounds cannot be unambiguously identified with high resolution MS1 measurements alone. MS/MS fragmentation yields confident identifications of these compounds, but how to ensure quality MS/MS of these compounds? Data dependent techniques, although very powerful, cannot guarantee the measurement of all possible MS/MS candidates. Targeted MS/MS ensures acquisition of the target compounds, but limits the number of compounds. Data-independent techniques, such as SWATHâ„¢ acquisition (the MS/MS of all possible candidates), improve identifications significantly and enable retrospective analysis of the data. The impact of improvements to SWATH acquisition, including variable precursor window sizes, overlapping windows, and data processing were evaluated. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/impactofnovelmsmsallacquisitionandprocessingtechniquesonforensictoxicologicalscreening-141119150803-conversion-gate02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Rapid forensic toxicology screening by high resolution mass spectrometry is a powerful technique. However, some compounds cannot be unambiguously identified with high resolution MS1 measurements alone. MS/MS fragmentation yields confident identifications of these compounds, but how to ensure quality MS/MS of these compounds? Data dependent techniques, although very powerful, cannot guarantee the measurement of all possible MS/MS candidates. Targeted MS/MS ensures acquisition of the target compounds, but limits the number of compounds. Data-independent techniques, such as SWATHâ„¢ acquisition (the MS/MS of all possible candidates), improve identifications significantly and enable retrospective analysis of the data. The impact of improvements to SWATH acquisition, including variable precursor window sizes, overlapping windows, and data processing were evaluated.
Impact of novel ms ms all acquisition and processing techniques on forensic toxicological screening from Sara Feltesse
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