際際滷shows by User: ssuserb22936 / http://www.slideshare.net/images/logo.gif 際際滷shows by User: ssuserb22936 / Tue, 29 Sep 2015 19:06:17 GMT 際際滷Share feed for 際際滷shows by User: ssuserb22936 从仂仍仂于 亳 仄舒亳仆亶 仗亳仆亳仗 2015 /slideshow/2015-53340006/53340006 2015-150929190617-lva1-app6892
丼亠亠 于亠仍亳舒亶亳 仗亠亟于亳亟亠仆亳 仂仍仂于舒: 1. 仂仗仂 仂 仂仄亠 (仄仂亠) 弍亠仍从仂于仂亶 仄仂仍亠从仍 仍亠亢亳 于 仂仆仂于亠 于亠亶 仗仂弍仍亠仄 亳亰亳从仂-亳仄亳亠从仂亶 仗亳仂亟 仄仂仂仍仂亞亳亳 仂亞舒仆亳亰仄仂于. 2. 丱仂仄仂仂仄 仂 仂亞仂仄仆亠 弍亠仍从仂于亠 仄仂仍亠从仍, 于 从仂仂 舒亟亳从舒仍 舒仗亠亟亠仍亠仆 于 仂仗亠亟亠仍亠仆仆仂仄 亟仍 从舒亢亟仂亞仂 于亳亟舒 仗仂磲从亠. 3. 弌仍仂亢仆仂 舒从仂亶 仄仂仍亠从仍 仂仍 于亠仍亳从舒, 仂 亠亠 从仂仗亳 仆亠 仄仂亢亠 仂亰亟舒于舒 于 从仍亠从亠 亰舒仆仂于仂. 仆舒 于仂亰仆亳从舒亠 仂仍足从仂 仗亳 仆舒仍亳亳亳 于 从仍亠从亠 亢亠 亞仂仂于仂亶 仄仂仍亠从仍 亰舒舒于从亳. Omnis molecula ex molecula 4. 舒亟亳从舒仍 仂仄仂仂仄仆仂亶 仄仂仍亠从仍 亰舒仆亳仄舒ﾑ 于 仆亠亶 仂于亠亠仆仆仂 仂仗亠亟亠仍亠仆仆仂亠 仄亠仂, 亳 仄舒仍亠亶亳亠 亳仄亳亠从亳亠 亳亰仄亠仆亠仆亳 于 亳 舒亟亳从舒仍舒, 亟仂仍亢仆 磦仍 亳仂仆亳从仂仄 仆仂于 仄舒足亳亶.]]>
丼亠亠 于亠仍亳舒亶亳 仗亠亟于亳亟亠仆亳 仂仍仂于舒: 1. 仂仗仂 仂 仂仄亠 (仄仂亠) 弍亠仍从仂于仂亶 仄仂仍亠从仍 仍亠亢亳 于 仂仆仂于亠 于亠亶 仗仂弍仍亠仄 亳亰亳从仂-亳仄亳亠从仂亶 仗亳仂亟 仄仂仂仍仂亞亳亳 仂亞舒仆亳亰仄仂于. 2. 丱仂仄仂仂仄 仂 仂亞仂仄仆亠 弍亠仍从仂于亠 仄仂仍亠从仍, 于 从仂仂 舒亟亳从舒仍 舒仗亠亟亠仍亠仆 于 仂仗亠亟亠仍亠仆仆仂仄 亟仍 从舒亢亟仂亞仂 于亳亟舒 仗仂磲从亠. 3. 弌仍仂亢仆仂 舒从仂亶 仄仂仍亠从仍 仂仍 于亠仍亳从舒, 仂 亠亠 从仂仗亳 仆亠 仄仂亢亠 仂亰亟舒于舒 于 从仍亠从亠 亰舒仆仂于仂. 仆舒 于仂亰仆亳从舒亠 仂仍足从仂 仗亳 仆舒仍亳亳亳 于 从仍亠从亠 亢亠 亞仂仂于仂亶 仄仂仍亠从仍 亰舒舒于从亳. Omnis molecula ex molecula 4. 舒亟亳从舒仍 仂仄仂仂仄仆仂亶 仄仂仍亠从仍 亰舒仆亳仄舒ﾑ 于 仆亠亶 仂于亠亠仆仆仂 仂仗亠亟亠仍亠仆仆仂亠 仄亠仂, 亳 仄舒仍亠亶亳亠 亳仄亳亠从亳亠 亳亰仄亠仆亠仆亳 于 亳 舒亟亳从舒仍舒, 亟仂仍亢仆 磦仍 亳仂仆亳从仂仄 仆仂于 仄舒足亳亶.]]> Tue, 29 Sep 2015 19:06:17 GMT /slideshow/2015-53340006/53340006 ssuserb22936@slideshare.net(ssuserb22936) 从仂仍仂于 亳 仄舒亳仆亶 仗亳仆亳仗 2015 ssuserb22936 丼亠亠 于亠仍亳舒亶亳 仗亠亟于亳亟亠仆亳 仂仍仂于舒: 1. 仂仗仂 仂 仂仄亠 (仄仂亠) 弍亠仍从仂于仂亶 仄仂仍亠从仍 仍亠亢亳 于 仂仆仂于亠 于亠亶 仗仂弍仍亠仄 亳亰亳从仂-亳仄亳亠从仂亶 仗亳仂亟 仄仂仂仍仂亞亳亳 仂亞舒仆亳亰仄仂于. 2. 丱仂仄仂仂仄 仂 仂亞仂仄仆亠 弍亠仍从仂于亠 仄仂仍亠从仍, 于 从仂仂 舒亟亳从舒仍 舒仗亠亟亠仍亠仆 于 仂仗亠亟亠仍亠仆仆仂仄 亟仍 从舒亢亟仂亞仂 于亳亟舒 仗仂磲从亠. 3. 弌仍仂亢仆仂 舒从仂亶 仄仂仍亠从仍 仂仍 于亠仍亳从舒, 仂 亠亠 从仂仗亳 仆亠 仄仂亢亠 仂亰亟舒于舒 于 从仍亠从亠 亰舒仆仂于仂. 仆舒 于仂亰仆亳从舒亠 仂仍足从仂 仗亳 仆舒仍亳亳亳 于 从仍亠从亠 亢亠 亞仂仂于仂亶 仄仂仍亠从仍 亰舒舒于从亳. Omnis molecula ex molecula 4. 舒亟亳从舒仍 仂仄仂仂仄仆仂亶 仄仂仍亠从仍 亰舒仆亳仄舒ﾑ 于 仆亠亶 仂于亠亠仆仆仂 仂仗亠亟亠仍亠仆仆仂亠 仄亠仂, 亳 仄舒仍亠亶亳亠 亳仄亳亠从亳亠 亳亰仄亠仆亠仆亳 于 亳 舒亟亳从舒仍舒, 亟仂仍亢仆 磦仍 亳仂仆亳从仂仄 仆仂于 仄舒足亳亶. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929190617-lva1-app6892-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> 丼亠亠 于亠仍亳舒亶亳 仗亠亟于亳亟亠仆亳 仂仍仂于舒: 1. 仂仗仂 仂 仂仄亠 (仄仂亠) 弍亠仍从仂于仂亶 仄仂仍亠从仍 仍亠亢亳 于 仂仆仂于亠 于亠亶 仗仂弍仍亠仄 亳亰亳从仂-亳仄亳亠从仂亶 仗亳仂亟 仄仂仂仍仂亞亳亳 仂亞舒仆亳亰仄仂于. 2. 丱仂仄仂仂仄 仂 仂亞仂仄仆亠 弍亠仍从仂于亠 仄仂仍亠从仍, 于 从仂仂 舒亟亳从舒仍 舒仗亠亟亠仍亠仆 于 仂仗亠亟亠仍亠仆仆仂仄 亟仍 从舒亢亟仂亞仂 于亳亟舒 仗仂磲从亠. 3. 弌仍仂亢仆仂 舒从仂亶 仄仂仍亠从仍 仂仍 于亠仍亳从舒, 仂 亠亠 从仂仗亳 仆亠 仄仂亢亠 仂亰亟舒于舒 于 从仍亠从亠 亰舒仆仂于仂. 仆舒 于仂亰仆亳从舒亠 仂仍足从仂 仗亳 仆舒仍亳亳亳 于 从仍亠从亠 亢亠 亞仂仂于仂亶 仄仂仍亠从仍 亰舒舒于从亳. Omnis molecula ex molecula 4. 舒亟亳从舒仍 仂仄仂仂仄仆仂亶 仄仂仍亠从仍 亰舒仆亳仄舒ﾑ 于 仆亠亶 仂于亠亠仆仆仂 仂仗亠亟亠仍亠仆仆仂亠 仄亠仂, 亳 仄舒仍亠亶亳亠 亳仄亳亠从亳亠 亳亰仄亠仆亠仆亳 于 亳 舒亟亳从舒仍舒, 亟仂仍亢仆 磦仍 亳仂仆亳从仂仄 仆仂于 仄舒足亳亶.
从仂仍仂于 亳 仄舒亳仆亶 仗亳仆亳仗 2015 from Nikita Khromov-Borisov
]]> 1237 5 https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929190617-lva1-app6892-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 仗舒舒亟仂从 仗仂亞亠仆仂仄亳从亳 2015 /ssuserb22936/2015-53324439 2015-150929130539-lva1-app6891
舒仆仂 仍舒弍仂 仂弍仂仆仂于舒仆仆亠 仗仂仗从亳 仗舒从亳亠从仂亞仂 亳仗仂仍亰仂于舒仆亳 仗仍仂仂 于仂仗仂亳亰于仂亟亳仄 亠亰仍舒仂于 仗仍仂仂 仗仍舒仆亳仂于舒仆仆 亳仍亠亟仂于舒仆亳亶 亞亠仆亠亳亠从亳 束舒仂亳舒亳亶損 亟仍 于磦仍亠仆亳 亳 仂弍仂舒 (亠于亞亠仆亳亠从仂亶 亠仍亠从亳亳) 仗仂亠仆亳舒仍仆 仍亳仆 舒仍亠仂于, 从舒从 仄亳仆亳仄仄, 仗亠亢亟亠于亠仄亠仆仆. 仂从舒 仂 仆亠仍亰 亳从仍ﾑ亳, 仂 舒从亳亠 亟亠亶于亳 仗亳仆亠 弍仂仍亠 于亠亟舒, 亠仄 仗仂仍亰. 舒亶 弍仂亞, 亠仍亳 亳 仗仂仍亠亟于亳 弍亟 仆亠亶舒仍仆仄亳.]]>
舒仆仂 仍舒弍仂 仂弍仂仆仂于舒仆仆亠 仗仂仗从亳 仗舒从亳亠从仂亞仂 亳仗仂仍亰仂于舒仆亳 仗仍仂仂 于仂仗仂亳亰于仂亟亳仄 亠亰仍舒仂于 仗仍仂仂 仗仍舒仆亳仂于舒仆仆 亳仍亠亟仂于舒仆亳亶 亞亠仆亠亳亠从亳 束舒仂亳舒亳亶損 亟仍 于磦仍亠仆亳 亳 仂弍仂舒 (亠于亞亠仆亳亠从仂亶 亠仍亠从亳亳) 仗仂亠仆亳舒仍仆 仍亳仆 舒仍亠仂于, 从舒从 仄亳仆亳仄仄, 仗亠亢亟亠于亠仄亠仆仆. 仂从舒 仂 仆亠仍亰 亳从仍ﾑ亳, 仂 舒从亳亠 亟亠亶于亳 仗亳仆亠 弍仂仍亠 于亠亟舒, 亠仄 仗仂仍亰. 舒亶 弍仂亞, 亠仍亳 亳 仗仂仍亠亟于亳 弍亟 仆亠亶舒仍仆仄亳.]]> Tue, 29 Sep 2015 13:05:38 GMT /ssuserb22936/2015-53324439 ssuserb22936@slideshare.net(ssuserb22936) 仗舒舒亟仂从 仗仂亞亠仆仂仄亳从亳 2015 ssuserb22936 舒仆仂 仍舒弍仂 仂弍仂仆仂于舒仆仆亠 仗仂仗从亳 仗舒从亳亠从仂亞仂 亳仗仂仍亰仂于舒仆亳 仗仍仂仂 于仂仗仂亳亰于仂亟亳仄 亠亰仍舒仂于 仗仍仂仂 仗仍舒仆亳仂于舒仆仆 亳仍亠亟仂于舒仆亳亶 亞亠仆亠亳亠从亳 束舒仂亳舒亳亶損 亟仍 于磦仍亠仆亳 亳 仂弍仂舒 (亠于亞亠仆亳亠从仂亶 亠仍亠从亳亳) 仗仂亠仆亳舒仍仆 仍亳仆 舒仍亠仂于, 从舒从 仄亳仆亳仄仄, 仗亠亢亟亠于亠仄亠仆仆. 仂从舒 仂 仆亠仍亰 亳从仍ﾑ亳, 仂 舒从亳亠 亟亠亶于亳 仗亳仆亠 弍仂仍亠 于亠亟舒, 亠仄 仗仂仍亰. 舒亶 弍仂亞, 亠仍亳 亳 仗仂仍亠亟于亳 弍亟 仆亠亶舒仍仆仄亳. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929130539-lva1-app6891-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> 舒仆仂 仍舒弍仂 仂弍仂仆仂于舒仆仆亠 仗仂仗从亳 仗舒从亳亠从仂亞仂 亳仗仂仍亰仂于舒仆亳 仗仍仂仂 于仂仗仂亳亰于仂亟亳仄 亠亰仍舒仂于 仗仍仂仂 仗仍舒仆亳仂于舒仆仆 亳仍亠亟仂于舒仆亳亶 亞亠仆亠亳亠从亳 束舒仂亳舒亳亶損 亟仍 于磦仍亠仆亳 亳 仂弍仂舒 (亠于亞亠仆亳亠从仂亶 亠仍亠从亳亳) 仗仂亠仆亳舒仍仆 仍亳仆 舒仍亠仂于, 从舒从 仄亳仆亳仄仄, 仗亠亢亟亠于亠仄亠仆仆. 仂从舒 仂 仆亠仍亰 亳从仍ﾑ亳, 仂 舒从亳亠 亟亠亶于亳 仗亳仆亠 弍仂仍亠 于亠亟舒, 亠仄 仗仂仍亰. 舒亶 弍仂亞, 亠仍亳 亳 仗仂仍亠亟于亳 弍亟 仆亠亶舒仍仆仄亳.
仗舒舒亟仂从 仗仂亞亠仆仂仄亳从亳 2015 from Nikita Khromov-Borisov
]]> 408 4 https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929130539-lva1-app6891-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 亳仄亳 亟仆从 亟仍 亞亠仆亠亳从仂于 2015 /slideshow/2015-53323885/53323885 2015-150929125352-lva1-app6892
1. 舒舒弍仆亠 舒仂仄仆仂-仄仂仍亠从仍仆亠 仄仂亟亠仍亳 亠从亳于仆亶 亳仆仄亠仆 仂弍亠仆亳 亳 亳仍亠亟仂于舒仆亳亶. 2. 丕舒仆舒于仍亳于舒 从 弍亳仂仄仂仍亠从仍, 亢亠仍舒亠仍仆仂 亰舒亟仄于舒 仂 亠亠 弍亳仂仍仂亞亳亠从仂仄 仗亠亟仆舒亰仆舒亠仆亳亳, 仂 亠亠 弍亳仂仍仂亞亳亠从仂亶 仆从亳亳. 3. 亠舒从亳亳 舒亰仍亳仆仄亳 舒亞亠仆舒仄亳 磦仍ﾑ 仂仗仂亳仄亳亠从亳仄亳 亳/亳仍亳 从仂仆亠从-亰舒于亳亳仄仄亳. 4. 亠亰 仗仂亟于亠亢亟亠仆亳 从 仗仂仄仂 仄舒舒弍仆 仄仂仍亠从仍仆 仄仂亟亠仍亠亶 于亠从亳亠 亞亳仗仂亠亳亠从亳亠 仗仂仂亠仆亳 仗仂亳 仆舒于亠仆磻舒 仂弍亠亠仆 仆舒 仗仂于舒仍. 5. 舒从舒 亠亟从仂 仂于亠舒亠 仆舒 于仂仗仂 束仗仂亠仄?損, 舒亠 仂仍从仂 仆舒 于仂仗仂 束从舒从?損. 6. 弌仂于亠仄亠仆仆舒 从仆舒 亳仄亳 亳从仍ﾑ亳亠仍仆仂 仗仍仂亟仂于仂仆仂 仂弍仆磳 亳 仗亠亟从舒亰于舒亠 亞亠仂仄亠亳 仄仂仍亠从仍. 7. 丐舒仂仄亠仆亶 亳 亳仂仆亳亰舒亳仂仆仆亶 仄亠舒仆亳亰仄 于仂亰仆亳从仆仂于亠仆亳 亰舒仄亠仆 仗舒 仂仆仂于舒仆亳亶 亳亟亠亳, 从仂仂亠 亟仆仂 亟仂从舒亰舒. 8. 束仂仆仂仄舒亳仂仆仆亶損 仄亠舒仆亳亰仄 仆亠仗舒于亳仍仆仂亞仂 仗舒亳于舒仆亳 仂仆仂于舒仆亳亶 仗亠亟舒于仍磳 仆舒亳弍仂仍亠亠 仗舒于亟仂仗仂亟仂弍仆仄. 9. 亳从舒从亳仄亳 亳仍舒仄亳 亳 仆亳从仂亞亟舒 仄 仆亠 仄仂亢亠仄 亳亰弍舒于亳 仂 舒亟亳仂舒从亳于仆 亳亰仂仂仗仂于 于 仗亳仂亟亠. 10. 个仂仂亟亳仄亠亳亰舒亳 亳仄亳仆舒 从舒 亟亠仄仂仆舒亳 仂仗仂亳仄亳亠从仂亶 仗亳仂亟 亠舒从亳亶 仄舒亞亠仆舒 . 11. 亰仂仆仂于亶 仍仂亶 于 舒仂亠亠 亟亠亶于亳亠仍仆仂 仆舒亟亠亢仆仂 亰舒亳舒亠 仆舒 仂 于亠亟仆仂亞仂 仄舒亞亠仆仆仂-从舒仆亠仂亞亠仆仆仂亞仂 亟亠亶于亳 从仂仂从仂于仂仍仆仂于仂亞仂 丕个-亳亰仍亠仆亳. 12. 仆仂于仆仂亶 (仄舒亢仂仆亶) 仗仂亟从 亠舒从亳亳 舒亞亠仆舒 亟舒仍亠从仂 仆亠 于亠亞亟舒 磦仍磳 仂仆仂于仆仂亶 仗亳亳仆仂亶 亠亞仂 仄舒亞亠仆仆仂亳. 丼亠仄 仄磪亠 仄舒亞亠仆, 亠仄 弍仂仍亠 亠亞仂 于亳亟仂于舒 亳 仍仂从仆舒 仗亠亳亳仆仂亳. 13. 亠仍亠仂亞亠仆 亳 舒仄仗仍亳亞亠仆 亰舒仍亢亳于舒ﾑ 仗亳舒仍仆仂亞仂 于仆亳仄舒仆亳. 14. 仆舒仍亳亰 亳 舒于仆亠仆亳亠 仄舒亳仂仆仆 仗亠从仂于 仗仂亟从亳于仆亶 仗仂亟仂亟 从 于磦仍亠仆亳 仂亟于舒 亳 舒亰仍亳亳亶 仄亠亢亟 仄舒亞亠仆舒仄亳.]]>
1. 舒舒弍仆亠 舒仂仄仆仂-仄仂仍亠从仍仆亠 仄仂亟亠仍亳 亠从亳于仆亶 亳仆仄亠仆 仂弍亠仆亳 亳 亳仍亠亟仂于舒仆亳亶. 2. 丕舒仆舒于仍亳于舒 从 弍亳仂仄仂仍亠从仍, 亢亠仍舒亠仍仆仂 亰舒亟仄于舒 仂 亠亠 弍亳仂仍仂亞亳亠从仂仄 仗亠亟仆舒亰仆舒亠仆亳亳, 仂 亠亠 弍亳仂仍仂亞亳亠从仂亶 仆从亳亳. 3. 亠舒从亳亳 舒亰仍亳仆仄亳 舒亞亠仆舒仄亳 磦仍ﾑ 仂仗仂亳仄亳亠从亳仄亳 亳/亳仍亳 从仂仆亠从-亰舒于亳亳仄仄亳. 4. 亠亰 仗仂亟于亠亢亟亠仆亳 从 仗仂仄仂 仄舒舒弍仆 仄仂仍亠从仍仆 仄仂亟亠仍亠亶 于亠从亳亠 亞亳仗仂亠亳亠从亳亠 仗仂仂亠仆亳 仗仂亳 仆舒于亠仆磻舒 仂弍亠亠仆 仆舒 仗仂于舒仍. 5. 舒从舒 亠亟从仂 仂于亠舒亠 仆舒 于仂仗仂 束仗仂亠仄?損, 舒亠 仂仍从仂 仆舒 于仂仗仂 束从舒从?損. 6. 弌仂于亠仄亠仆仆舒 从仆舒 亳仄亳 亳从仍ﾑ亳亠仍仆仂 仗仍仂亟仂于仂仆仂 仂弍仆磳 亳 仗亠亟从舒亰于舒亠 亞亠仂仄亠亳 仄仂仍亠从仍. 7. 丐舒仂仄亠仆亶 亳 亳仂仆亳亰舒亳仂仆仆亶 仄亠舒仆亳亰仄 于仂亰仆亳从仆仂于亠仆亳 亰舒仄亠仆 仗舒 仂仆仂于舒仆亳亶 亳亟亠亳, 从仂仂亠 亟仆仂 亟仂从舒亰舒. 8. 束仂仆仂仄舒亳仂仆仆亶損 仄亠舒仆亳亰仄 仆亠仗舒于亳仍仆仂亞仂 仗舒亳于舒仆亳 仂仆仂于舒仆亳亶 仗亠亟舒于仍磳 仆舒亳弍仂仍亠亠 仗舒于亟仂仗仂亟仂弍仆仄. 9. 亳从舒从亳仄亳 亳仍舒仄亳 亳 仆亳从仂亞亟舒 仄 仆亠 仄仂亢亠仄 亳亰弍舒于亳 仂 舒亟亳仂舒从亳于仆 亳亰仂仂仗仂于 于 仗亳仂亟亠. 10. 个仂仂亟亳仄亠亳亰舒亳 亳仄亳仆舒 从舒 亟亠仄仂仆舒亳 仂仗仂亳仄亳亠从仂亶 仗亳仂亟 亠舒从亳亶 仄舒亞亠仆舒 . 11. 亰仂仆仂于亶 仍仂亶 于 舒仂亠亠 亟亠亶于亳亠仍仆仂 仆舒亟亠亢仆仂 亰舒亳舒亠 仆舒 仂 于亠亟仆仂亞仂 仄舒亞亠仆仆仂-从舒仆亠仂亞亠仆仆仂亞仂 亟亠亶于亳 从仂仂从仂于仂仍仆仂于仂亞仂 丕个-亳亰仍亠仆亳. 12. 仆仂于仆仂亶 (仄舒亢仂仆亶) 仗仂亟从 亠舒从亳亳 舒亞亠仆舒 亟舒仍亠从仂 仆亠 于亠亞亟舒 磦仍磳 仂仆仂于仆仂亶 仗亳亳仆仂亶 亠亞仂 仄舒亞亠仆仆仂亳. 丼亠仄 仄磪亠 仄舒亞亠仆, 亠仄 弍仂仍亠 亠亞仂 于亳亟仂于舒 亳 仍仂从仆舒 仗亠亳亳仆仂亳. 13. 亠仍亠仂亞亠仆 亳 舒仄仗仍亳亞亠仆 亰舒仍亢亳于舒ﾑ 仗亳舒仍仆仂亞仂 于仆亳仄舒仆亳. 14. 仆舒仍亳亰 亳 舒于仆亠仆亳亠 仄舒亳仂仆仆 仗亠从仂于 仗仂亟从亳于仆亶 仗仂亟仂亟 从 于磦仍亠仆亳 仂亟于舒 亳 舒亰仍亳亳亶 仄亠亢亟 仄舒亞亠仆舒仄亳.]]> Tue, 29 Sep 2015 12:53:52 GMT /slideshow/2015-53323885/53323885 ssuserb22936@slideshare.net(ssuserb22936) 亳仄亳 亟仆从 亟仍 亞亠仆亠亳从仂于 2015 ssuserb22936 1. 舒舒弍仆亠 舒仂仄仆仂-仄仂仍亠从仍仆亠 仄仂亟亠仍亳 亠从亳于仆亶 亳仆仄亠仆 仂弍亠仆亳 亳 亳仍亠亟仂于舒仆亳亶. 2. 丕舒仆舒于仍亳于舒 从 弍亳仂仄仂仍亠从仍, 亢亠仍舒亠仍仆仂 亰舒亟仄于舒 仂 亠亠 弍亳仂仍仂亞亳亠从仂仄 仗亠亟仆舒亰仆舒亠仆亳亳, 仂 亠亠 弍亳仂仍仂亞亳亠从仂亶 仆从亳亳. 3. 亠舒从亳亳 舒亰仍亳仆仄亳 舒亞亠仆舒仄亳 磦仍ﾑ 仂仗仂亳仄亳亠从亳仄亳 亳/亳仍亳 从仂仆亠从-亰舒于亳亳仄仄亳. 4. 亠亰 仗仂亟于亠亢亟亠仆亳 从 仗仂仄仂 仄舒舒弍仆 仄仂仍亠从仍仆 仄仂亟亠仍亠亶 于亠从亳亠 亞亳仗仂亠亳亠从亳亠 仗仂仂亠仆亳 仗仂亳 仆舒于亠仆磻舒 仂弍亠亠仆 仆舒 仗仂于舒仍. 5. 舒从舒 亠亟从仂 仂于亠舒亠 仆舒 于仂仗仂 束仗仂亠仄?損, 舒亠 仂仍从仂 仆舒 于仂仗仂 束从舒从?損. 6. 弌仂于亠仄亠仆仆舒 从仆舒 亳仄亳 亳从仍ﾑ亳亠仍仆仂 仗仍仂亟仂于仂仆仂 仂弍仆磳 亳 仗亠亟从舒亰于舒亠 亞亠仂仄亠亳 仄仂仍亠从仍. 7. 丐舒仂仄亠仆亶 亳 亳仂仆亳亰舒亳仂仆仆亶 仄亠舒仆亳亰仄 于仂亰仆亳从仆仂于亠仆亳 亰舒仄亠仆 仗舒 仂仆仂于舒仆亳亶 亳亟亠亳, 从仂仂亠 亟仆仂 亟仂从舒亰舒. 8. 束仂仆仂仄舒亳仂仆仆亶損 仄亠舒仆亳亰仄 仆亠仗舒于亳仍仆仂亞仂 仗舒亳于舒仆亳 仂仆仂于舒仆亳亶 仗亠亟舒于仍磳 仆舒亳弍仂仍亠亠 仗舒于亟仂仗仂亟仂弍仆仄. 9. 亳从舒从亳仄亳 亳仍舒仄亳 亳 仆亳从仂亞亟舒 仄 仆亠 仄仂亢亠仄 亳亰弍舒于亳 仂 舒亟亳仂舒从亳于仆 亳亰仂仂仗仂于 于 仗亳仂亟亠. 10. 个仂仂亟亳仄亠亳亰舒亳 亳仄亳仆舒 从舒 亟亠仄仂仆舒亳 仂仗仂亳仄亳亠从仂亶 仗亳仂亟 亠舒从亳亶 仄舒亞亠仆舒 . 11. 亰仂仆仂于亶 仍仂亶 于 舒仂亠亠 亟亠亶于亳亠仍仆仂 仆舒亟亠亢仆仂 亰舒亳舒亠 仆舒 仂 于亠亟仆仂亞仂 仄舒亞亠仆仆仂-从舒仆亠仂亞亠仆仆仂亞仂 亟亠亶于亳 从仂仂从仂于仂仍仆仂于仂亞仂 丕个-亳亰仍亠仆亳. 12. 仆仂于仆仂亶 (仄舒亢仂仆亶) 仗仂亟从 亠舒从亳亳 舒亞亠仆舒 亟舒仍亠从仂 仆亠 于亠亞亟舒 磦仍磳 仂仆仂于仆仂亶 仗亳亳仆仂亶 亠亞仂 仄舒亞亠仆仆仂亳. 丼亠仄 仄磪亠 仄舒亞亠仆, 亠仄 弍仂仍亠 亠亞仂 于亳亟仂于舒 亳 仍仂从仆舒 仗亠亳亳仆仂亳. 13. 亠仍亠仂亞亠仆 亳 舒仄仗仍亳亞亠仆 亰舒仍亢亳于舒ﾑ 仗亳舒仍仆仂亞仂 于仆亳仄舒仆亳. 14. 仆舒仍亳亰 亳 舒于仆亠仆亳亠 仄舒亳仂仆仆 仗亠从仂于 仗仂亟从亳于仆亶 仗仂亟仂亟 从 于磦仍亠仆亳 仂亟于舒 亳 舒亰仍亳亳亶 仄亠亢亟 仄舒亞亠仆舒仄亳. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929125352-lva1-app6892-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> 1. 舒舒弍仆亠 舒仂仄仆仂-仄仂仍亠从仍仆亠 仄仂亟亠仍亳 亠从亳于仆亶 亳仆仄亠仆 仂弍亠仆亳 亳 亳仍亠亟仂于舒仆亳亶. 2. 丕舒仆舒于仍亳于舒 从 弍亳仂仄仂仍亠从仍, 亢亠仍舒亠仍仆仂 亰舒亟仄于舒 仂 亠亠 弍亳仂仍仂亞亳亠从仂仄 仗亠亟仆舒亰仆舒亠仆亳亳, 仂 亠亠 弍亳仂仍仂亞亳亠从仂亶 仆从亳亳. 3. 亠舒从亳亳 舒亰仍亳仆仄亳 舒亞亠仆舒仄亳 磦仍ﾑ 仂仗仂亳仄亳亠从亳仄亳 亳/亳仍亳 从仂仆亠从-亰舒于亳亳仄仄亳. 4. 亠亰 仗仂亟于亠亢亟亠仆亳 从 仗仂仄仂 仄舒舒弍仆 仄仂仍亠从仍仆 仄仂亟亠仍亠亶 于亠从亳亠 亞亳仗仂亠亳亠从亳亠 仗仂仂亠仆亳 仗仂亳 仆舒于亠仆磻舒 仂弍亠亠仆 仆舒 仗仂于舒仍. 5. 舒从舒 亠亟从仂 仂于亠舒亠 仆舒 于仂仗仂 束仗仂亠仄?損, 舒亠 仂仍从仂 仆舒 于仂仗仂 束从舒从?損. 6. 弌仂于亠仄亠仆仆舒 从仆舒 亳仄亳 亳从仍ﾑ亳亠仍仆仂 仗仍仂亟仂于仂仆仂 仂弍仆磳 亳 仗亠亟从舒亰于舒亠 亞亠仂仄亠亳 仄仂仍亠从仍. 7. 丐舒仂仄亠仆亶 亳 亳仂仆亳亰舒亳仂仆仆亶 仄亠舒仆亳亰仄 于仂亰仆亳从仆仂于亠仆亳 亰舒仄亠仆 仗舒 仂仆仂于舒仆亳亶 亳亟亠亳, 从仂仂亠 亟仆仂 亟仂从舒亰舒. 8. 束仂仆仂仄舒亳仂仆仆亶損 仄亠舒仆亳亰仄 仆亠仗舒于亳仍仆仂亞仂 仗舒亳于舒仆亳 仂仆仂于舒仆亳亶 仗亠亟舒于仍磳 仆舒亳弍仂仍亠亠 仗舒于亟仂仗仂亟仂弍仆仄. 9. 亳从舒从亳仄亳 亳仍舒仄亳 亳 仆亳从仂亞亟舒 仄 仆亠 仄仂亢亠仄 亳亰弍舒于亳 仂 舒亟亳仂舒从亳于仆 亳亰仂仂仗仂于 于 仗亳仂亟亠. 10. 个仂仂亟亳仄亠亳亰舒亳 亳仄亳仆舒 从舒 亟亠仄仂仆舒亳 仂仗仂亳仄亳亠从仂亶 仗亳仂亟 亠舒从亳亶 仄舒亞亠仆舒 . 11. 亰仂仆仂于亶 仍仂亶 于 舒仂亠亠 亟亠亶于亳亠仍仆仂 仆舒亟亠亢仆仂 亰舒亳舒亠 仆舒 仂 于亠亟仆仂亞仂 仄舒亞亠仆仆仂-从舒仆亠仂亞亠仆仆仂亞仂 亟亠亶于亳 从仂仂从仂于仂仍仆仂于仂亞仂 丕个-亳亰仍亠仆亳. 12. 仆仂于仆仂亶 (仄舒亢仂仆亶) 仗仂亟从 亠舒从亳亳 舒亞亠仆舒 亟舒仍亠从仂 仆亠 于亠亞亟舒 磦仍磳 仂仆仂于仆仂亶 仗亳亳仆仂亶 亠亞仂 仄舒亞亠仆仆仂亳. 丼亠仄 仄磪亠 仄舒亞亠仆, 亠仄 弍仂仍亠 亠亞仂 于亳亟仂于舒 亳 仍仂从仆舒 仗亠亳亳仆仂亳. 13. 亠仍亠仂亞亠仆 亳 舒仄仗仍亳亞亠仆 亰舒仍亢亳于舒ﾑ 仗亳舒仍仆仂亞仂 于仆亳仄舒仆亳. 14. 仆舒仍亳亰 亳 舒于仆亠仆亳亠 仄舒亳仂仆仆 仗亠从仂于 仗仂亟从亳于仆亶 仗仂亟仂亟 从 于磦仍亠仆亳 仂亟于舒 亳 舒亰仍亳亳亶 仄亠亢亟 仄舒亞亠仆舒仄亳.
亳仄亳 亟仆从 亟仍 亞亠仆亠亳从仂于 2015 from Nikita Khromov-Borisov
]]> 710 4 https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929125352-lva1-app6892-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 仗舒舒亟仂从 亞亠仆仂仄仆仂亶 仄亠亟亳亳仆 2015 /slideshow/2015-53323837/53323837 2015-150929125300-lva1-app6891
舒舒亟仂从 亞亠仆亠亳亠从仂亶 仆亳从舒仍仆仂亳 舒舒亟仂从 亞亠仆亠亳亠从仂亞仂 舒亰仆仂仂弍舒亰亳 舒舒亟仂从 舒亰仄仂亳 亠仆仂亳仗仂于 舒舒亟仂从 从仂仆仂仍仆仂亶 亞仗仗 舒舒亟仂从 仄仄亳仂于舒仆亳 弍舒仍仍仂于 亞亠仆亠亳亠从仂亞仂 亳从舒 舒舒亟仂从 仄仆仂亢亠于亠仆仆 舒于仆亠仆亳亶 舒舒亟仂从 仂弍舒仆仂亶 于亠仂仆仂亳 (束亰舒弍仍亢亟亠仆亳亠 仂弍于亳仆亳亠仍晛) P-亰仆舒亠仆亳亠 于亠仍亳舒亶亠亠 舒亳亳亠从仂亠 亰舒弍仍亢亟亠仆亳亠 FDA 仗亠亟仗亠亢亟舒亠 亳 仂弍于亳仆磳: 亞亠仆亠亳亠从仂亠 亠亳仂于舒仆亳亠 仆舒仆仂 仆亠 仂弍仂仆仂于舒仆仂]]>
舒舒亟仂从 亞亠仆亠亳亠从仂亶 仆亳从舒仍仆仂亳 舒舒亟仂从 亞亠仆亠亳亠从仂亞仂 舒亰仆仂仂弍舒亰亳 舒舒亟仂从 舒亰仄仂亳 亠仆仂亳仗仂于 舒舒亟仂从 从仂仆仂仍仆仂亶 亞仗仗 舒舒亟仂从 仄仄亳仂于舒仆亳 弍舒仍仍仂于 亞亠仆亠亳亠从仂亞仂 亳从舒 舒舒亟仂从 仄仆仂亢亠于亠仆仆 舒于仆亠仆亳亶 舒舒亟仂从 仂弍舒仆仂亶 于亠仂仆仂亳 (束亰舒弍仍亢亟亠仆亳亠 仂弍于亳仆亳亠仍晛) P-亰仆舒亠仆亳亠 于亠仍亳舒亶亠亠 舒亳亳亠从仂亠 亰舒弍仍亢亟亠仆亳亠 FDA 仗亠亟仗亠亢亟舒亠 亳 仂弍于亳仆磳: 亞亠仆亠亳亠从仂亠 亠亳仂于舒仆亳亠 仆舒仆仂 仆亠 仂弍仂仆仂于舒仆仂]]> Tue, 29 Sep 2015 12:53:00 GMT /slideshow/2015-53323837/53323837 ssuserb22936@slideshare.net(ssuserb22936) 仗舒舒亟仂从 亞亠仆仂仄仆仂亶 仄亠亟亳亳仆 2015 ssuserb22936 舒舒亟仂从 亞亠仆亠亳亠从仂亶 仆亳从舒仍仆仂亳 舒舒亟仂从 亞亠仆亠亳亠从仂亞仂 舒亰仆仂仂弍舒亰亳 舒舒亟仂从 舒亰仄仂亳 亠仆仂亳仗仂于 舒舒亟仂从 从仂仆仂仍仆仂亶 亞仗仗 舒舒亟仂从 仄仄亳仂于舒仆亳 弍舒仍仍仂于 亞亠仆亠亳亠从仂亞仂 亳从舒 舒舒亟仂从 仄仆仂亢亠于亠仆仆 舒于仆亠仆亳亶 舒舒亟仂从 仂弍舒仆仂亶 于亠仂仆仂亳 (束亰舒弍仍亢亟亠仆亳亠 仂弍于亳仆亳亠仍晛) P-亰仆舒亠仆亳亠 于亠仍亳舒亶亠亠 舒亳亳亠从仂亠 亰舒弍仍亢亟亠仆亳亠 FDA 仗亠亟仗亠亢亟舒亠 亳 仂弍于亳仆磳: 亞亠仆亠亳亠从仂亠 亠亳仂于舒仆亳亠 仆舒仆仂 仆亠 仂弍仂仆仂于舒仆仂 <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929125300-lva1-app6891-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> 舒舒亟仂从 亞亠仆亠亳亠从仂亶 仆亳从舒仍仆仂亳 舒舒亟仂从 亞亠仆亠亳亠从仂亞仂 舒亰仆仂仂弍舒亰亳 舒舒亟仂从 舒亰仄仂亳 亠仆仂亳仗仂于 舒舒亟仂从 从仂仆仂仍仆仂亶 亞仗仗 舒舒亟仂从 仄仄亳仂于舒仆亳 弍舒仍仍仂于 亞亠仆亠亳亠从仂亞仂 亳从舒 舒舒亟仂从 仄仆仂亢亠于亠仆仆 舒于仆亠仆亳亶 舒舒亟仂从 仂弍舒仆仂亶 于亠仂仆仂亳 (束亰舒弍仍亢亟亠仆亳亠 仂弍于亳仆亳亠仍晛) P-亰仆舒亠仆亳亠 于亠仍亳舒亶亠亠 舒亳亳亠从仂亠 亰舒弍仍亢亟亠仆亳亠 FDA 仗亠亟仗亠亢亟舒亠 亳 仂弍于亳仆磳: 亞亠仆亠亳亠从仂亠 亠亳仂于舒仆亳亠 仆舒仆仂 仆亠 仂弍仂仆仂于舒仆仂
仗舒舒亟仂从 亞亠仆仂仄仆仂亶 仄亠亟亳亳仆 2015 from Nikita Khromov-Borisov
]]> 349 4 https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929125300-lva1-app6891-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Harmonizing statistical evidences and predictions /slideshow/harmonizing-statistical-evidences-and-predictions/39602402 harmonizingstatisticalevidencesandpredictions-140927141637-phpapp01
Bad reproducibility of experimental results becomes a systemic problem in biomedicine. One of the main reason of this is inadequate statistical analysis. Statistical analysis should be comprehensive harmonizing statistical evidences and predictions as well as frequentist and Bayesian approaches. It is insufficient to carry out the null hypothesis significance testing (NHST) reporting P-values. Statistical significance doesnt mean clinical importance. Effect size with confidence and prediction intervals should be reported. Experiments an/or observations should be repeated many-many times and their agreement should be investigated. The best way is to repeat the experiments independently in different laboratories (in different countries).]]>
Bad reproducibility of experimental results becomes a systemic problem in biomedicine. One of the main reason of this is inadequate statistical analysis. Statistical analysis should be comprehensive harmonizing statistical evidences and predictions as well as frequentist and Bayesian approaches. It is insufficient to carry out the null hypothesis significance testing (NHST) reporting P-values. Statistical significance doesnt mean clinical importance. Effect size with confidence and prediction intervals should be reported. Experiments an/or observations should be repeated many-many times and their agreement should be investigated. The best way is to repeat the experiments independently in different laboratories (in different countries).]]> Sat, 27 Sep 2014 14:16:37 GMT /slideshow/harmonizing-statistical-evidences-and-predictions/39602402 ssuserb22936@slideshare.net(ssuserb22936) Harmonizing statistical evidences and predictions ssuserb22936 Bad reproducibility of experimental results becomes a systemic problem in biomedicine. One of the main reason of this is inadequate statistical analysis. Statistical analysis should be comprehensive harmonizing statistical evidences and predictions as well as frequentist and Bayesian approaches. It is insufficient to carry out the null hypothesis significance testing (NHST) reporting P-values. Statistical significance doesnt mean clinical importance. Effect size with confidence and prediction intervals should be reported. Experiments an/or observations should be repeated many-many times and their agreement should be investigated. The best way is to repeat the experiments independently in different laboratories (in different countries). <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/harmonizingstatisticalevidencesandpredictions-140927141637-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Bad reproducibility of experimental results becomes a systemic problem in biomedicine. One of the main reason of this is inadequate statistical analysis. Statistical analysis should be comprehensive harmonizing statistical evidences and predictions as well as frequentist and Bayesian approaches. It is insufficient to carry out the null hypothesis significance testing (NHST) reporting P-values. Statistical significance doesnt mean clinical importance. Effect size with confidence and prediction intervals should be reported. Experiments an/or observations should be repeated many-many times and their agreement should be investigated. The best way is to repeat the experiments independently in different laboratories (in different countries).
Harmonizing statistical evidences and predictions from Nikita Khromov-Borisov
]]> 1315 9 https://cdn.slidesharecdn.com/ss_thumbnails/harmonizingstatisticalevidencesandpredictions-140927141637-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Evolutionary arguments in medical genomics /slideshow/evolutionary-arguments-in-medical-genomics-39602331/39602331 evolutionaryargumentsinmedicalgenomics-140927141146-phpapp01
Evolutionary medical genomics, whether we realize it or not, is the foundation of genetics of predispositions whose main goal should not be personalized prediction of disease risk, but to develop strategies for its treatment and prevention on the basis of the knowledge of its genetic, evolutionary history and molecular mechanisms.]]>
Evolutionary medical genomics, whether we realize it or not, is the foundation of genetics of predispositions whose main goal should not be personalized prediction of disease risk, but to develop strategies for its treatment and prevention on the basis of the knowledge of its genetic, evolutionary history and molecular mechanisms.]]> Sat, 27 Sep 2014 14:11:46 GMT /slideshow/evolutionary-arguments-in-medical-genomics-39602331/39602331 ssuserb22936@slideshare.net(ssuserb22936) Evolutionary arguments in medical genomics ssuserb22936 Evolutionary medical genomics, whether we realize it or not, is the foundation of genetics of predispositions whose main goal should not be personalized prediction of disease risk, but to develop strategies for its treatment and prevention on the basis of the knowledge of its genetic, evolutionary history and molecular mechanisms. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/evolutionaryargumentsinmedicalgenomics-140927141146-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Evolutionary medical genomics, whether we realize it or not, is the foundation of genetics of predispositions whose main goal should not be personalized prediction of disease risk, but to develop strategies for its treatment and prevention on the basis of the knowledge of its genetic, evolutionary history and molecular mechanisms.
Evolutionary arguments in medical genomics from Nikita Khromov-Borisov
]]> 1458 11 https://cdn.slidesharecdn.com/ss_thumbnails/evolutionaryargumentsinmedicalgenomics-140927141146-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 从亳亰亳 于仂仗仂亳亰于仂亟亳仄仂亳 于 弍亳仂仄亠亟亳亳仆亠 Rus 2014 /slideshow/rus-2014/37929356 rus2014-140812165511-phpapp01
仍仂舒 于仂仗仂亳亰于仂亟亳仄仂 亠亰仍舒仂于 从仗亠亳仄亠仆仂于 亳 仆舒弍仍ﾐ莞黍出湖 弍亳 仂于亠仄亠仆仆仂亶 弍亳仂仄亠亟亳亳仆 亳 亠亠 亳亠仄仆舒 仗仂弍仍亠仄舒]]>
仍仂舒 于仂仗仂亳亰于仂亟亳仄仂 亠亰仍舒仂于 从仗亠亳仄亠仆仂于 亳 仆舒弍仍ﾐ莞黍出湖 弍亳 仂于亠仄亠仆仆仂亶 弍亳仂仄亠亟亳亳仆 亳 亠亠 亳亠仄仆舒 仗仂弍仍亠仄舒]]> Tue, 12 Aug 2014 16:55:11 GMT /slideshow/rus-2014/37929356 ssuserb22936@slideshare.net(ssuserb22936) 从亳亰亳 于仂仗仂亳亰于仂亟亳仄仂亳 于 弍亳仂仄亠亟亳亳仆亠 Rus 2014 ssuserb22936 仍仂舒 于仂仗仂亳亰于仂亟亳仄仂 亠亰仍舒仂于 从仗亠亳仄亠仆仂于 亳 仆舒弍仍ﾐ莞黍出湖 弍亳 仂于亠仄亠仆仆仂亶 弍亳仂仄亠亟亳亳仆 亳 亠亠 亳亠仄仆舒 仗仂弍仍亠仄舒 <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/rus2014-140812165511-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> 仍仂舒 于仂仗仂亳亰于仂亟亳仄仂 亠亰仍舒仂于 从仗亠亳仄亠仆仂于 亳 仆舒弍仍ﾐ莞黍出湖 弍亳 仂于亠仄亠仆仆仂亶 弍亳仂仄亠亟亳亳仆 亳 亠亠 亳亠仄仆舒 仗仂弍仍亠仄舒
从亳亰亳 于仂仗仂亳亰于仂亟亳仄仂亳 于 弍亳仂仄亠亟亳亳仆亠 Rus 2014 from Nikita Khromov-Borisov
]]> 789 3 https://cdn.slidesharecdn.com/ss_thumbnails/rus2014-140812165511-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Prematurity of genetic testing of predispositions rus 2014 /slideshow/prematurity-of-genetic-testing-of-predispositions-rus-2014/37928951 prematurityofgenetictestingofpredispositionsrus2014-140812163940-phpapp01
仂从舒 仄 仆亠 于磦亳仄 弍仂仍亳仆于仂 仗仂仍亳仄仂亳亰仄仂于 亳 仆亠 舒亰弍亠亠仄 于 亳 仗亠亟仆舒亰仆舒亠仆亳亳, 亟仂 亠 仗仂 从仍亳仆亳亠从仂亠 仗亳仄亠仆亠仆亳亠 亞亠仆亠亳亠从仂亞仂 亠亳仂于舒仆亳 弍亟亠 仂舒于舒 仄舒仍仂亳仆仂仄舒亳于仆仄 亳 仗仂仂仄 磦仆仂 仗亠亢亟亠于亠仄亠仆仆仄. 舒亟仂 仆舒仍仂亢亳 仄仂舒仂亳亶 仆舒 仗仂仗亠仆亠 从仍亳仆亳亠从亳亠 (亳 亳仆亠 仗舒从亳亠从亳亠) 仗亳仄亠仆亠仆亳 亠亰仍舒仂于 亞亠仆亠亳从亳 仗亠亟舒仗仂仍仂亢亠仆仆仂亠亶. 舒亟仂 仗亳仂舒仆仂于亳 亟亠亠仍仆仂 亳仄 亳 亳仄仂亠从, 亰舒仆亳仄舒ﾑ亳 亞舒亟舒仆亳亠仄 仆舒 亞亠仆仆仂亶 亞亠 亳/亳仍亳 仂舒于仍亠仆亳亠仄 亞亠仆亠亳亠从亳 亞仂仂从仂仗仂于. ]]>
仂从舒 仄 仆亠 于磦亳仄 弍仂仍亳仆于仂 仗仂仍亳仄仂亳亰仄仂于 亳 仆亠 舒亰弍亠亠仄 于 亳 仗亠亟仆舒亰仆舒亠仆亳亳, 亟仂 亠 仗仂 从仍亳仆亳亠从仂亠 仗亳仄亠仆亠仆亳亠 亞亠仆亠亳亠从仂亞仂 亠亳仂于舒仆亳 弍亟亠 仂舒于舒 仄舒仍仂亳仆仂仄舒亳于仆仄 亳 仗仂仂仄 磦仆仂 仗亠亢亟亠于亠仄亠仆仆仄. 舒亟仂 仆舒仍仂亢亳 仄仂舒仂亳亶 仆舒 仗仂仗亠仆亠 从仍亳仆亳亠从亳亠 (亳 亳仆亠 仗舒从亳亠从亳亠) 仗亳仄亠仆亠仆亳 亠亰仍舒仂于 亞亠仆亠亳从亳 仗亠亟舒仗仂仍仂亢亠仆仆仂亠亶. 舒亟仂 仗亳仂舒仆仂于亳 亟亠亠仍仆仂 亳仄 亳 亳仄仂亠从, 亰舒仆亳仄舒ﾑ亳 亞舒亟舒仆亳亠仄 仆舒 亞亠仆仆仂亶 亞亠 亳/亳仍亳 仂舒于仍亠仆亳亠仄 亞亠仆亠亳亠从亳 亞仂仂从仂仗仂于. ]]> Tue, 12 Aug 2014 16:39:40 GMT /slideshow/prematurity-of-genetic-testing-of-predispositions-rus-2014/37928951 ssuserb22936@slideshare.net(ssuserb22936) Prematurity of genetic testing of predispositions rus 2014 ssuserb22936 仂从舒 仄 仆亠 于磦亳仄 弍仂仍亳仆于仂 仗仂仍亳仄仂亳亰仄仂于 亳 仆亠 舒亰弍亠亠仄 于 亳 仗亠亟仆舒亰仆舒亠仆亳亳, 亟仂 亠 仗仂 从仍亳仆亳亠从仂亠 仗亳仄亠仆亠仆亳亠 亞亠仆亠亳亠从仂亞仂 亠亳仂于舒仆亳 弍亟亠 仂舒于舒 仄舒仍仂亳仆仂仄舒亳于仆仄 亳 仗仂仂仄 磦仆仂 仗亠亢亟亠于亠仄亠仆仆仄. 舒亟仂 仆舒仍仂亢亳 仄仂舒仂亳亶 仆舒 仗仂仗亠仆亠 从仍亳仆亳亠从亳亠 (亳 亳仆亠 仗舒从亳亠从亳亠) 仗亳仄亠仆亠仆亳 亠亰仍舒仂于 亞亠仆亠亳从亳 仗亠亟舒仗仂仍仂亢亠仆仆仂亠亶. 舒亟仂 仗亳仂舒仆仂于亳 亟亠亠仍仆仂 亳仄 亳 亳仄仂亠从, 亰舒仆亳仄舒ﾑ亳 亞舒亟舒仆亳亠仄 仆舒 亞亠仆仆仂亶 亞亠 亳/亳仍亳 仂舒于仍亠仆亳亠仄 亞亠仆亠亳亠从亳 亞仂仂从仂仗仂于. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/prematurityofgenetictestingofpredispositionsrus2014-140812163940-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> 仂从舒 仄 仆亠 于磦亳仄 弍仂仍亳仆于仂 仗仂仍亳仄仂亳亰仄仂于 亳 仆亠 舒亰弍亠亠仄 于 亳 仗亠亟仆舒亰仆舒亠仆亳亳, 亟仂 亠 仗仂 从仍亳仆亳亠从仂亠 仗亳仄亠仆亠仆亳亠 亞亠仆亠亳亠从仂亞仂 亠亳仂于舒仆亳 弍亟亠 仂舒于舒 仄舒仍仂亳仆仂仄舒亳于仆仄 亳 仗仂仂仄 磦仆仂 仗亠亢亟亠于亠仄亠仆仆仄. 舒亟仂 仆舒仍仂亢亳 仄仂舒仂亳亶 仆舒 仗仂仗亠仆亠 从仍亳仆亳亠从亳亠 (亳 亳仆亠 仗舒从亳亠从亳亠) 仗亳仄亠仆亠仆亳 亠亰仍舒仂于 亞亠仆亠亳从亳 仗亠亟舒仗仂仍仂亢亠仆仆仂亠亶. 舒亟仂 仗亳仂舒仆仂于亳 亟亠亠仍仆仂 亳仄 亳 亳仄仂亠从, 亰舒仆亳仄舒ﾑ亳 亞舒亟舒仆亳亠仄 仆舒 亞亠仆仆仂亶 亞亠 亳/亳仍亳 仂舒于仍亠仆亳亠仄 亞亠仆亠亳亠从亳 亞仂仂从仂仗仂于.
Prematurity of genetic testing of predispositions rus 2014 from Nikita Khromov-Borisov
]]> 583 5 https://cdn.slidesharecdn.com/ss_thumbnails/prematurityofgenetictestingofpredispositionsrus2014-140812163940-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Syndrome of statistical leniency ppt /slideshow/syndrome-of-statistical-leniency-ppt/37928504 syndromeofstatisticalleniencyppt-140812162611-phpapp01
Syndrome of statistical lenien]]>
Syndrome of statistical lenien]]> Tue, 12 Aug 2014 16:26:11 GMT /slideshow/syndrome-of-statistical-leniency-ppt/37928504 ssuserb22936@slideshare.net(ssuserb22936) Syndrome of statistical leniency ppt ssuserb22936 Syndrome of statistical lenien <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/syndromeofstatisticalleniencyppt-140812162611-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Syndrome of statistical lenien
Syndrome of statistical leniency ppt from Nikita Khromov-Borisov
]]> 564 3 https://cdn.slidesharecdn.com/ss_thumbnails/syndromeofstatisticalleniencyppt-140812162611-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Reproducibility and predictivity in the genetics of predispositions ppt 2013 /slideshow/reproducibility-and-predictivity-in-the-genetics-of-predispositions-ppt-2013/37928402 reproducibilityandpredictivityinthegeneticsofpredispositionsppt2013-140812162319-phpapp02
Poor reproducibility and low predictive values of the results in the genetics of predispositions become a systemic problem. Results of the statistical quality control of genetic tests in the study should be supported with not only integral indices such as odds ratios (OR), but with the post-test (posterior) predictive probabilities (PPV and NPV) and likelihood ratios (LR[+] and LR[-]). Usefulness of predictiveness graphs for visualization of the relationships between the prevalence as a pretest (prior) probability of disease and predictive values PPV and NPV as posttest (posterior) probabilities is demonstrated. Predictive capabilities of widely used genetic, observational, instrumental and immunological diagnostic tests are discussed. Several examples of such tests are presented and it is shown that despite of their high statistical significance they are not able to provide clinically important association between the disease and biomarker. The predictive power of the vast majority of genetic markers (given very wide confidence intervals due to small sample sizes) differs little from the population prevalence of the disease. Extremely rare the odds ratios in the studies on the genetics of dispositions exceed practically critical OR = 5. As a result, in most cases, recommendations of medical geneticists are based on clinically negligible (though statistically significant) recognizablity and predictability of genetic markers.]]>
Poor reproducibility and low predictive values of the results in the genetics of predispositions become a systemic problem. Results of the statistical quality control of genetic tests in the study should be supported with not only integral indices such as odds ratios (OR), but with the post-test (posterior) predictive probabilities (PPV and NPV) and likelihood ratios (LR[+] and LR[-]). Usefulness of predictiveness graphs for visualization of the relationships between the prevalence as a pretest (prior) probability of disease and predictive values PPV and NPV as posttest (posterior) probabilities is demonstrated. Predictive capabilities of widely used genetic, observational, instrumental and immunological diagnostic tests are discussed. Several examples of such tests are presented and it is shown that despite of their high statistical significance they are not able to provide clinically important association between the disease and biomarker. The predictive power of the vast majority of genetic markers (given very wide confidence intervals due to small sample sizes) differs little from the population prevalence of the disease. Extremely rare the odds ratios in the studies on the genetics of dispositions exceed practically critical OR = 5. As a result, in most cases, recommendations of medical geneticists are based on clinically negligible (though statistically significant) recognizablity and predictability of genetic markers.]]> Tue, 12 Aug 2014 16:23:19 GMT /slideshow/reproducibility-and-predictivity-in-the-genetics-of-predispositions-ppt-2013/37928402 ssuserb22936@slideshare.net(ssuserb22936) Reproducibility and predictivity in the genetics of predispositions ppt 2013 ssuserb22936 Poor reproducibility and low predictive values of the results in the genetics of predispositions become a systemic problem. Results of the statistical quality control of genetic tests in the study should be supported with not only integral indices such as odds ratios (OR), but with the post-test (posterior) predictive probabilities (PPV and NPV) and likelihood ratios (LR[+] and LR[-]). Usefulness of predictiveness graphs for visualization of the relationships between the prevalence as a pretest (prior) probability of disease and predictive values PPV and NPV as posttest (posterior) probabilities is demonstrated. Predictive capabilities of widely used genetic, observational, instrumental and immunological diagnostic tests are discussed. Several examples of such tests are presented and it is shown that despite of their high statistical significance they are not able to provide clinically important association between the disease and biomarker. The predictive power of the vast majority of genetic markers (given very wide confidence intervals due to small sample sizes) differs little from the population prevalence of the disease. Extremely rare the odds ratios in the studies on the genetics of dispositions exceed practically critical OR = 5. As a result, in most cases, recommendations of medical geneticists are based on clinically negligible (though statistically significant) recognizablity and predictability of genetic markers. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/reproducibilityandpredictivityinthegeneticsofpredispositionsppt2013-140812162319-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Poor reproducibility and low predictive values of the results in the genetics of predispositions become a systemic problem. Results of the statistical quality control of genetic tests in the study should be supported with not only integral indices such as odds ratios (OR), but with the post-test (posterior) predictive probabilities (PPV and NPV) and likelihood ratios (LR[+] and LR[-]). Usefulness of predictiveness graphs for visualization of the relationships between the prevalence as a pretest (prior) probability of disease and predictive values PPV and NPV as posttest (posterior) probabilities is demonstrated. Predictive capabilities of widely used genetic, observational, instrumental and immunological diagnostic tests are discussed. Several examples of such tests are presented and it is shown that despite of their high statistical significance they are not able to provide clinically important association between the disease and biomarker. The predictive power of the vast majority of genetic markers (given very wide confidence intervals due to small sample sizes) differs little from the population prevalence of the disease. Extremely rare the odds ratios in the studies on the genetics of dispositions exceed practically critical OR = 5. As a result, in most cases, recommendations of medical geneticists are based on clinically negligible (though statistically significant) recognizablity and predictability of genetic markers.
Reproducibility and predictivity in the genetics of predispositions ppt 2013 from Nikita Khromov-Borisov
]]> 580 5 https://cdn.slidesharecdn.com/ss_thumbnails/reproducibilityandpredictivityinthegeneticsofpredispositionsppt2013-140812162319-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Population thinking in studies of genetic predispositions ppt /slideshow/population-thinking-in-studies-of-genetic-predispositions-ppt/37928377 populationthinkinginstudiesofgeneticpredispositionsppt-140812162243-phpapp01
Population thinking in the genetics of predispositions]]>
Population thinking in the genetics of predispositions]]> Tue, 12 Aug 2014 16:22:43 GMT /slideshow/population-thinking-in-studies-of-genetic-predispositions-ppt/37928377 ssuserb22936@slideshare.net(ssuserb22936) Population thinking in studies of genetic predispositions ppt ssuserb22936 Population thinking in the genetics of predispositions <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/populationthinkinginstudiesofgeneticpredispositionsppt-140812162243-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Population thinking in the genetics of predispositions
Population thinking in studies of genetic predispositions ppt from Nikita Khromov-Borisov
]]> 1074 3 https://cdn.slidesharecdn.com/ss_thumbnails/populationthinkinginstudiesofgeneticpredispositionsppt-140812162243-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Modern free biostatistical software ppt /slideshow/modern-free-biostatistical-software-ppt/37928347 modernfreebiostatisticalsoftwareppt-140812162144-phpapp01
Modern free biostatistical software]]>
Modern free biostatistical software]]> Tue, 12 Aug 2014 16:21:44 GMT /slideshow/modern-free-biostatistical-software-ppt/37928347 ssuserb22936@slideshare.net(ssuserb22936) Modern free biostatistical software ppt ssuserb22936 Modern free biostatistical software <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/modernfreebiostatisticalsoftwareppt-140812162144-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Modern free biostatistical software
Modern free biostatistical software ppt from Nikita Khromov-Borisov
]]> 914 2 https://cdn.slidesharecdn.com/ss_thumbnails/modernfreebiostatisticalsoftwareppt-140812162144-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Half a century with the central dogma of molecular biology ppt /slideshow/half-a-century-with-the-central-dogma-of-molecular-biology-ppt/37928320 halfacenturywiththecentraldogmaofmolecularbiologyppt-140812162040-phpapp01
Half of century with the Central dogma of molecular biology]]>
Half of century with the Central dogma of molecular biology]]> Tue, 12 Aug 2014 16:20:40 GMT /slideshow/half-a-century-with-the-central-dogma-of-molecular-biology-ppt/37928320 ssuserb22936@slideshare.net(ssuserb22936) Half a century with the central dogma of molecular biology ppt ssuserb22936 Half of century with the Central dogma of molecular biology <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/halfacenturywiththecentraldogmaofmolecularbiologyppt-140812162040-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Half of century with the Central dogma of molecular biology
Half a century with the central dogma of molecular biology ppt from Nikita Khromov-Borisov
]]> 771 5 https://cdn.slidesharecdn.com/ss_thumbnails/halfacenturywiththecentraldogmaofmolecularbiologyppt-140812162040-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Genetics of predispositions ppt /ssuserb22936/genetics-of-predispositions-ppt geneticsofpredispositionsppt-140812161956-phpapp02
Genetics of predispositions]]>
Genetics of predispositions]]> Tue, 12 Aug 2014 16:19:56 GMT /ssuserb22936/genetics-of-predispositions-ppt ssuserb22936@slideshare.net(ssuserb22936) Genetics of predispositions ppt ssuserb22936 Genetics of predispositions <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/geneticsofpredispositionsppt-140812161956-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Genetics of predispositions
Genetics of predispositions ppt from Nikita Khromov-Borisov
]]> 779 2 https://cdn.slidesharecdn.com/ss_thumbnails/geneticsofpredispositionsppt-140812161956-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Format for the population data in forensic genetics ppt /slideshow/format-for-the-population-data-in-forensic-genetics-ppt/37928271 formatforthepopulationdatainforensicgeneticsppt-140812161900-phpapp02
Format for the population data in forensic genetics]]>
Format for the population data in forensic genetics]]> Tue, 12 Aug 2014 16:18:59 GMT /slideshow/format-for-the-population-data-in-forensic-genetics-ppt/37928271 ssuserb22936@slideshare.net(ssuserb22936) Format for the population data in forensic genetics ppt ssuserb22936 Format for the population data in forensic genetics <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/formatforthepopulationdatainforensicgeneticsppt-140812161900-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Format for the population data in forensic genetics
Format for the population data in forensic genetics ppt from Nikita Khromov-Borisov
]]> 865 4 https://cdn.slidesharecdn.com/ss_thumbnails/formatforthepopulationdatainforensicgeneticsppt-140812161900-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Evolutionary medical genomics ppt 2013 /slideshow/evolutionary-medical-genomics-ppt-2013/37928223 evolutionarymedicalgenomicsppt2013-140812161725-phpapp02
束Nothing in biomedicine makes sense except in the light of evolution損. From this point of view, genetics of predispositions has to answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neutral evolution or whether it is an aggravated genetic (mutation) load determining the susceptibility to common diseases, which inexplicably has not been culled by the natural selection well-timed? 2. Are effects of different predisposing alleles synergistic or at least additive when combined in a single genotype, or they are mutually neutralized? Evolutionary and population arguments help to understand that the 束genetics of predispositions損 studies natural balanced genetic polymorphism, i.e. not newly formed alterations of genes (mutations), but alleles passed natural selection and fixed in human populations. Not anomalies, not pathological or pathogenic variants of the genome are investigated, but infinite number of its natural, 束normal損 variants. Thus the answers on the above two questions are: 1. Evolutionary medical genomics testifies that the vast majority of polymorphic variants of genes (alleles) that are observed in the genomes of modern human populations are selectively neutral. 2. In many cases, the effects of various predisposing alleles are mutually neutralized through the mechanisms of opposite (antagonistic) pleiotropy and homeostasis.]]>
束Nothing in biomedicine makes sense except in the light of evolution損. From this point of view, genetics of predispositions has to answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neutral evolution or whether it is an aggravated genetic (mutation) load determining the susceptibility to common diseases, which inexplicably has not been culled by the natural selection well-timed? 2. Are effects of different predisposing alleles synergistic or at least additive when combined in a single genotype, or they are mutually neutralized? Evolutionary and population arguments help to understand that the 束genetics of predispositions損 studies natural balanced genetic polymorphism, i.e. not newly formed alterations of genes (mutations), but alleles passed natural selection and fixed in human populations. Not anomalies, not pathological or pathogenic variants of the genome are investigated, but infinite number of its natural, 束normal損 variants. Thus the answers on the above two questions are: 1. Evolutionary medical genomics testifies that the vast majority of polymorphic variants of genes (alleles) that are observed in the genomes of modern human populations are selectively neutral. 2. In many cases, the effects of various predisposing alleles are mutually neutralized through the mechanisms of opposite (antagonistic) pleiotropy and homeostasis.]]> Tue, 12 Aug 2014 16:17:25 GMT /slideshow/evolutionary-medical-genomics-ppt-2013/37928223 ssuserb22936@slideshare.net(ssuserb22936) Evolutionary medical genomics ppt 2013 ssuserb22936 束Nothing in biomedicine makes sense except in the light of evolution損. From this point of view, genetics of predispositions has to answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neutral evolution or whether it is an aggravated genetic (mutation) load determining the susceptibility to common diseases, which inexplicably has not been culled by the natural selection well-timed? 2. Are effects of different predisposing alleles synergistic or at least additive when combined in a single genotype, or they are mutually neutralized? Evolutionary and population arguments help to understand that the 束genetics of predispositions損 studies natural balanced genetic polymorphism, i.e. not newly formed alterations of genes (mutations), but alleles passed natural selection and fixed in human populations. Not anomalies, not pathological or pathogenic variants of the genome are investigated, but infinite number of its natural, 束normal損 variants. Thus the answers on the above two questions are: 1. Evolutionary medical genomics testifies that the vast majority of polymorphic variants of genes (alleles) that are observed in the genomes of modern human populations are selectively neutral. 2. In many cases, the effects of various predisposing alleles are mutually neutralized through the mechanisms of opposite (antagonistic) pleiotropy and homeostasis. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/evolutionarymedicalgenomicsppt2013-140812161725-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> 束Nothing in biomedicine makes sense except in the light of evolution損. From this point of view, genetics of predispositions has to answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neutral evolution or whether it is an aggravated genetic (mutation) load determining the susceptibility to common diseases, which inexplicably has not been culled by the natural selection well-timed? 2. Are effects of different predisposing alleles synergistic or at least additive when combined in a single genotype, or they are mutually neutralized? Evolutionary and population arguments help to understand that the 束genetics of predispositions損 studies natural balanced genetic polymorphism, i.e. not newly formed alterations of genes (mutations), but alleles passed natural selection and fixed in human populations. Not anomalies, not pathological or pathogenic variants of the genome are investigated, but infinite number of its natural, 束normal損 variants. Thus the answers on the above two questions are: 1. Evolutionary medical genomics testifies that the vast majority of polymorphic variants of genes (alleles) that are observed in the genomes of modern human populations are selectively neutral. 2. In many cases, the effects of various predisposing alleles are mutually neutralized through the mechanisms of opposite (antagonistic) pleiotropy and homeostasis.
Evolutionary medical genomics ppt 2013 from Nikita Khromov-Borisov
]]> 809 2 https://cdn.slidesharecdn.com/ss_thumbnails/evolutionarymedicalgenomicsppt2013-140812161725-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Catalog of formulae for forensic genetics ppt /slideshow/catalog-of-formulae-for-forensic-genetics-ppt/37928183 catalogofformulaeforforensicgeneticsppt-140812161615-phpapp01
Catalog of formulae for forensic genetics]]>
Catalog of formulae for forensic genetics]]> Tue, 12 Aug 2014 16:16:15 GMT /slideshow/catalog-of-formulae-for-forensic-genetics-ppt/37928183 ssuserb22936@slideshare.net(ssuserb22936) Catalog of formulae for forensic genetics ppt ssuserb22936 Catalog of formulae for forensic genetics <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/catalogofformulaeforforensicgeneticsppt-140812161615-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Catalog of formulae for forensic genetics
Catalog of formulae for forensic genetics ppt from Nikita Khromov-Borisov
]]> 1143 7 https://cdn.slidesharecdn.com/ss_thumbnails/catalogofformulaeforforensicgeneticsppt-140812161615-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Biometrical problems in population studies ppt 2004 /slideshow/biometrical-problems-in-population-studies-ppt-2004/37928098 biometricalproblemsinpopulationstudiesppt2004-140812161310-phpapp02
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]]> Tue, 12 Aug 2014 16:13:10 GMT /slideshow/biometrical-problems-in-population-studies-ppt-2004/37928098 ssuserb22936@slideshare.net(ssuserb22936) Biometrical problems in population studies ppt 2004 ssuserb22936 <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/biometricalproblemsinpopulationstudiesppt2004-140812161310-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Biometrical problems in population studies ppt 2004 from Nikita Khromov-Borisov
]]> 626 6 https://cdn.slidesharecdn.com/ss_thumbnails/biometricalproblemsinpopulationstudiesppt2004-140812161310-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Joshua lederberg ppt /ssuserb22936/joshua-lederberg-ppt joshualederbergppt-140812161013-phpapp01
Joshua Lederberg - encyclopedist of the XX century]]>
Joshua Lederberg - encyclopedist of the XX century]]> Tue, 12 Aug 2014 16:10:12 GMT /ssuserb22936/joshua-lederberg-ppt ssuserb22936@slideshare.net(ssuserb22936) Joshua lederberg ppt ssuserb22936 Joshua Lederberg - encyclopedist of the XX century <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/joshualederbergppt-140812161013-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Joshua Lederberg - encyclopedist of the XX century
Joshua lederberg ppt from Nikita Khromov-Borisov
]]> 2020 18 https://cdn.slidesharecdn.com/ss_thumbnails/joshualederbergppt-140812161013-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Reproducibility of results in the genetics of predisposition eng 2014 /slideshow/reproducibility-of-results-in-the-genetics-of-presiposition-eng-2014/37927815 reproducibilityofresultsinthegeneticsofpresipositioneng2014-140812160416-phpapp01
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]]> Tue, 12 Aug 2014 16:04:16 GMT /slideshow/reproducibility-of-results-in-the-genetics-of-presiposition-eng-2014/37927815 ssuserb22936@slideshare.net(ssuserb22936) Reproducibility of results in the genetics of predisposition eng 2014 ssuserb22936 <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/reproducibilityofresultsinthegeneticsofpresipositioneng2014-140812160416-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Reproducibility of results in the genetics of predisposition eng 2014 from Nikita Khromov-Borisov
]]> 982 16 https://cdn.slidesharecdn.com/ss_thumbnails/reproducibilityofresultsinthegeneticsofpresipositioneng2014-140812160416-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation 000000 http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-ssuserb22936-48x48.jpg?cb=1524109766 https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929190617-lva1-app6892-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/2015-53340006/53340006 从仂仍仂于 亳 仄舒亳仆亶 仗... https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929130539-lva1-app6891-thumbnail.jpg?width=320&height=320&fit=bounds ssuserb22936/2015-53324439 仗舒舒亟仂从 仗仂亞亠仆仂仄亳从... https://cdn.slidesharecdn.com/ss_thumbnails/2015-150929125352-lva1-app6892-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/2015-53323885/53323885 亳仄亳 亟仆从 亟仍 亞亠仆亠亳从仂...