�ݺ�ߣshows by User: surbhimadan7

�ݺ�ߣshows by User: surbhimadan7 / http://www.slideshare.net/images/logo.gif �ݺ�ߣshows by User: surbhimadan7 / Thu, 18 Apr 2019 10:49:47 GMT �ݺ�ߣShare feed for �ݺ�ߣshows by User: surbhimadan7 Brain targeting /slideshow/brain-targeting/141172598 braintargeting-190418104947
Brain Targeted Drug Delivery System Prepared by : Surbhi M.Pharmacy II sem Submitted to : Dr. Anupama Diwan MAGIC BULLET : CONCEPT OF PAUL EHRLICH Brain Targeting: Challenges Blood brain barrier (BBB): Brain is tightly segregated from the circulating blood by a unique membranous barrier. The brain and spinal cord are lined with a layer of special endothelial cells that lack fenestrations and are sealed with tight junctions that greatly restrict passage of substances from the bloodstream. These endothelial cells, together with perivascular elements such as astrocytes and pericytes, constitute the BBB. Rate-limiting factor in determining permeation. The factors affecting particular substance to cross BBB Drug related factors at the BBB Concentration at the BBB and the size, Flexibility, Conformation, Ionization (nonionized form penetrates BBB) Lipophilicity of the drug molecule, Cellular enzyme stability and cellular sequestration, Affinity for efflux mechanisms (i.e. P-glycoprotein), Hydrogen bonding potential (i.e. charge), Affinity for carrier mechanisms, and Effect on all of the above by the existing pathological conditions Transport Mechanisms Several specialized transport mechanisms of solute transfer across endothelial cells and into the brain interstitium are also present within the BBB Carrier system for monosaccharides, monocarboxylic acid, neutral amino acids, basic amino acid, acidic amino acids, amines, purine bases, nucleosides, vitamins and hormones. The more lipophilic substances that are present in the blood can diffuse passively directly through the lipid of the cell membrane and enter the endothelial cells and brain by this means. Strategies for Brain Targeting Mechanisms for drug targeting in the brain involve going either "through" or "behind" the BBB. Neurosurgical or Invasive Strategies BBB disruption :Disruption of BBB by osmotic means (Hyperosmolar solutions), Intraventricular drug infusion Intracerebral Implants: Biodegradable implants, Physiologic based Strategies Psuedo nutrients eg L-dopa Cationic antibodies.These undergo Absorption mediated trancytosis through BBB owing to positive charge. Chimeric peptides. ]]>
Brain Targeted Drug Delivery System Prepared by : Surbhi M.Pharmacy II sem Submitted to : Dr. Anupama Diwan MAGIC BULLET : CONCEPT OF PAUL EHRLICH Brain Targeting: Challenges Blood brain barrier (BBB): Brain is tightly segregated from the circulating blood by a unique membranous barrier. The brain and spinal cord are lined with a layer of special endothelial cells that lack fenestrations and are sealed with tight junctions that greatly restrict passage of substances from the bloodstream. These endothelial cells, together with perivascular elements such as astrocytes and pericytes, constitute the BBB. Rate-limiting factor in determining permeation. The factors affecting particular substance to cross BBB Drug related factors at the BBB Concentration at the BBB and the size, Flexibility, Conformation, Ionization (nonionized form penetrates BBB) Lipophilicity of the drug molecule, Cellular enzyme stability and cellular sequestration, Affinity for efflux mechanisms (i.e. P-glycoprotein), Hydrogen bonding potential (i.e. charge), Affinity for carrier mechanisms, and Effect on all of the above by the existing pathological conditions Transport Mechanisms Several specialized transport mechanisms of solute transfer across endothelial cells and into the brain interstitium are also present within the BBB Carrier system for monosaccharides, monocarboxylic acid, neutral amino acids, basic amino acid, acidic amino acids, amines, purine bases, nucleosides, vitamins and hormones. The more lipophilic substances that are present in the blood can diffuse passively directly through the lipid of the cell membrane and enter the endothelial cells and brain by this means. Strategies for Brain Targeting Mechanisms for drug targeting in the brain involve going either "through" or "behind" the BBB. Neurosurgical or Invasive Strategies BBB disruption :Disruption of BBB by osmotic means (Hyperosmolar solutions), Intraventricular drug infusion Intracerebral Implants: Biodegradable implants, Physiologic based Strategies Psuedo nutrients eg L-dopa Cationic antibodies.These undergo Absorption mediated trancytosis through BBB owing to positive charge. Chimeric peptides. ]]> Thu, 18 Apr 2019 10:49:47 GMT /slideshow/brain-targeting/141172598 surbhimadan7@slideshare.net(surbhimadan7) Brain targeting surbhimadan7 Brain Targeted Drug Delivery System Prepared by : Surbhi M.Pharmacy II sem Submitted to : Dr. Anupama Diwan MAGIC BULLET : CONCEPT OF PAUL EHRLICH Brain Targeting: Challenges Blood brain barrier (BBB): Brain is tightly segregated from the circulating blood by a unique membranous barrier. The brain and spinal cord are lined with a layer of special endothelial cells that lack fenestrations and are sealed with tight junctions that greatly restrict passage of substances from the bloodstream. These endothelial cells, together with perivascular elements such as astrocytes and pericytes, constitute the BBB. Rate-limiting factor in determining permeation. The factors affecting particular substance to cross BBB Drug related factors at the BBB Concentration at the BBB and the size, Flexibility, Conformation, Ionization (nonionized form penetrates BBB) Lipophilicity of the drug molecule, Cellular enzyme stability and cellular sequestration, Affinity for efflux mechanisms (i.e. P-glycoprotein), Hydrogen bonding potential (i.e. charge), Affinity for carrier mechanisms, and Effect on all of the above by the existing pathological conditions Transport Mechanisms Several specialized transport mechanisms of solute transfer across endothelial cells and into the brain interstitium are also present within the BBB Carrier system for monosaccharides, monocarboxylic acid, neutral amino acids, basic amino acid, acidic amino acids, amines, purine bases, nucleosides, vitamins and hormones. The more lipophilic substances that are present in the blood can diffuse passively directly through the lipid of the cell membrane and enter the endothelial cells and brain by this means. Strategies for Brain Targeting Mechanisms for �drug targeting in the brain involve going either �"through" or "behind" the BBB. Neurosurgical or Invasive Strategies BBB disruption :Disruption of BBB by osmotic means (Hyperosmolar solutions), Intraventricular drug infusion Intracerebral Implants: Biodegradable implants, Physiologic based Strategies Psuedo nutrients eg L-dopa Cationic antibodies.These undergo Absorption mediated trancytosis through BBB owing to positive charge. Chimeric peptides. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/braintargeting-190418104947-thumbnail.jpg?width=120&height=120&fit=bounds" /> Brain Targeted Drug Delivery System Prepared by : Surbhi M.Pharmacy II sem Submitted to : Dr. Anupama Diwan MAGIC BULLET : CONCEPT OF PAUL EHRLICH Brain Targeting: Challenges Blood brain barrier (BBB): Brain is tightly segregated from the circulating blood by a unique membranous barrier. The brain and spinal cord are lined with a layer of special endothelial cells that lack fenestrations and are sealed with tight junctions that greatly restrict passage of substances from the bloodstream. These endothelial cells, together with perivascular elements such as astrocytes and pericytes, constitute the BBB. Rate-limiting factor in determining permeation. The factors affecting particular substance to cross BBB Drug related factors at the BBB Concentration at the BBB and the size, Flexibility, Conformation, Ionization (nonionized form penetrates BBB) Lipophilicity of the drug molecule, Cellular enzyme stability and cellular sequestration, Affinity for efflux mechanisms (i.e. P-glycoprotein), Hydrogen bonding potential (i.e. charge), Affinity for carrier mechanisms, and Effect on all of the above by the existing pathological conditions Transport Mechanisms Several specialized transport mechanisms of solute transfer across endothelial cells and into the brain interstitium are also present within the BBB Carrier system for monosaccharides, monocarboxylic acid, neutral amino acids, basic amino acid, acidic amino acids, amines, purine bases, nucleosides, vitamins and hormones. The more lipophilic substances that are present in the blood can diffuse passively directly through the lipid of the cell membrane and enter the endothelial cells and brain by this means. Strategies for Brain Targeting Mechanisms for �drug targeting in the brain involve going either �"through" or "behind" the BBB. Neurosurgical or Invasive Strategies BBB disruption :Disruption of BBB by osmotic means (Hyperosmolar solutions), Intraventricular drug infusion Intracerebral Implants: Biodegradable implants, Physiologic based Strategies Psuedo nutrients eg L-dopa Cationic antibodies.These undergo Absorption mediated trancytosis through BBB owing to positive charge. Chimeric peptides.

Brain targeting from Surbhi Narang

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0 Computer aided formulation development /slideshow/computer-aided-formulation-development/139550307 computer-aidedformulationdevelopment-190404132207
Concept of optimization optimisation in formulation development computer assisted aided]]>
Concept of optimization optimisation in formulation development computer assisted aided]]> Thu, 04 Apr 2019 13:22:07 GMT /slideshow/computer-aided-formulation-development/139550307 surbhimadan7@slideshare.net(surbhimadan7) Computer aided formulation development surbhimadan7 Concept of optimization optimisation in formulation development computer assisted aided <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/computer-aidedformulationdevelopment-190404132207-thumbnail.jpg?width=120&height=120&fit=bounds" /> Concept of optimization optimisation in formulation development computer assisted aided

Computer aided formulation development from Surbhi Narang

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0 Consolidation parameters /slideshow/consolidation-parameters/126273964 consolidationparameters-181219130123
KINETIC MODELING ON DRUG RELEASE FROM CONTROLLED DRUG DELIVERY SYSTEMS, Noyes-Whitney Rule Nernst and Brunner Film Theory ● Statistical methods (exploratory data analysis method, repeated measures design, multivariate approach [MANOVA: multivariate analysis of variance] (13, 14). ● Model dependent methods (zero order, first order, Higuchi, Korsmeyer-Peppas model, Hixson Crowell, Baker-Lonsdale model, Weibull model, etc.) (15, 16). ● Model independent methods [difference factor (f1), similarity factor (f2) ( ]]>
KINETIC MODELING ON DRUG RELEASE FROM CONTROLLED DRUG DELIVERY SYSTEMS, Noyes-Whitney Rule Nernst and Brunner Film Theory ● Statistical methods (exploratory data analysis method, repeated measures design, multivariate approach [MANOVA: multivariate analysis of variance] (13, 14). ● Model dependent methods (zero order, first order, Higuchi, Korsmeyer-Peppas model, Hixson Crowell, Baker-Lonsdale model, Weibull model, etc.) (15, 16). ● Model independent methods [difference factor (f1), similarity factor (f2) ( ]]> Wed, 19 Dec 2018 13:01:23 GMT /slideshow/consolidation-parameters/126273964 surbhimadan7@slideshare.net(surbhimadan7) Consolidation parameters surbhimadan7 KINETIC MODELING ON DRUG RELEASE FROM CONTROLLED DRUG DELIVERY SYSTEMS, Noyes-Whitney Rule Nernst and Brunner Film Theory ● Statistical methods (exploratory data analysis method, repeated measures design, multivariate approach [MANOVA: multivariate analysis of variance] (13, 14). ● Model dependent methods (zero order, first order, Higuchi, Korsmeyer-Peppas model, Hixson Crowell, Baker-Lonsdale model, Weibull model, etc.) (15, 16). ● Model independent methods [difference factor (f1), similarity factor (f2) ( <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/consolidationparameters-181219130123-thumbnail.jpg?width=120&height=120&fit=bounds" /> KINETIC MODELING ON DRUG RELEASE FROM CONTROLLED DRUG DELIVERY SYSTEMS, Noyes-Whitney Rule Nernst and Brunner Film Theory ● Statistical methods (exploratory data analysis method, repeated measures design, multivariate approach [MANOVA: multivariate analysis of variance] (13, 14). ● Model dependent methods (zero order, first order, Higuchi, Korsmeyer-Peppas model, Hixson Crowell, Baker-Lonsdale model, Weibull model, etc.) (15, 16). ● Model independent methods [difference factor (f1), similarity factor (f2) (

Consolidation parameters from Surbhi Narang

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0 Mass spectrometry and ionization techniques /slideshow/mass-spectrometry-and-ionization-techniques/125572825 massspectrometry-181211043205
ESI, APPI, APCI, MALDI, FAB, DESORPTION IONIZATION TECHNIQUES, MASS SPECTROSCOPY, photoionization]]>
ESI, APPI, APCI, MALDI, FAB, DESORPTION IONIZATION TECHNIQUES, MASS SPECTROSCOPY, photoionization]]> Tue, 11 Dec 2018 04:32:05 GMT /slideshow/mass-spectrometry-and-ionization-techniques/125572825 surbhimadan7@slideshare.net(surbhimadan7) Mass spectrometry and ionization techniques surbhimadan7 ESI, APPI, APCI, MALDI, FAB, DESORPTION IONIZATION TECHNIQUES, MASS SPECTROSCOPY, photoionization <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/massspectrometry-181211043205-thumbnail.jpg?width=120&height=120&fit=bounds" /> ESI, APPI, APCI, MALDI, FAB, DESORPTION IONIZATION TECHNIQUES, MASS SPECTROSCOPY, photoionization

Mass spectrometry and ionization techniques from Surbhi Narang

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0 ultra voilet chemical derivatisation /slideshow/ultra-voilet-chemical-derivatisation/123691448 uv-chemicalderivatisation-181122084352
ultra voilet chemical derivatisation- ultra voilet spectroscopy - various mechanisms -diazonium salts evaluation ]]>
ultra voilet chemical derivatisation- ultra voilet spectroscopy - various mechanisms -diazonium salts evaluation ]]> Thu, 22 Nov 2018 08:43:52 GMT /slideshow/ultra-voilet-chemical-derivatisation/123691448 surbhimadan7@slideshare.net(surbhimadan7) ultra voilet chemical derivatisation surbhimadan7 ultra voilet chemical derivatisation- ultra voilet spectroscopy - various mechanisms -diazonium salts evaluation <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/uv-chemicalderivatisation-181122084352-thumbnail.jpg?width=120&height=120&fit=bounds" /> ultra voilet chemical derivatisation- ultra voilet spectroscopy - various mechanisms -diazonium salts evaluation

ultra voilet chemical derivatisation from Surbhi Narang

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0 Feedback regulated drug delivery system /slideshow/feedback-regulated-drug-delivery-system/123690393 feedbackregulateddrugdeliverysystem-181122082702
Feedback regulated Drug Delivery system in rate controlled drug delivery systems ]]>
Feedback regulated Drug Delivery system in rate controlled drug delivery systems ]]> Thu, 22 Nov 2018 08:27:02 GMT /slideshow/feedback-regulated-drug-delivery-system/123690393 surbhimadan7@slideshare.net(surbhimadan7) Feedback regulated drug delivery system surbhimadan7 Feedback regulated Drug Delivery system in rate controlled drug delivery systems <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/feedbackregulateddrugdeliverysystem-181122082702-thumbnail.jpg?width=120&height=120&fit=bounds" /> Feedback regulated Drug Delivery system in rate controlled drug delivery systems

Feedback regulated drug delivery system from Surbhi Narang

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0 https://public.slidesharecdn.com/v2/images/profile-picture.png https://cdn.slidesharecdn.com/ss_thumbnails/braintargeting-190418104947-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/brain-targeting/141172598 Brain targeting https://cdn.slidesharecdn.com/ss_thumbnails/computer-aidedformulationdevelopment-190404132207-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/computer-aided-formulation-development/139550307 Computer aided formula... https://cdn.slidesharecdn.com/ss_thumbnails/consolidationparameters-181219130123-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/consolidation-parameters/126273964 Consolidation parameters