ºÝºÝߣshows by User: thinkpatrick / http://www.slideshare.net/images/logo.gif ºÝºÝߣshows by User: thinkpatrick / Tue, 14 May 2013 10:36:34 GMT ºÝºÝߣShare feed for ºÝºÝߣshows by User: thinkpatrick Phenotypic Plasticity, CYP19A1 Pleiotropy, and Maladaptive Selection in Developmental Disorders /thinkpatrick/phenotypic-plasticity-cyp19a1-pleiotropy-and-maladaptive-selection-in-developmental-disorders phenotypicplasticitycyp19a1pleiotropyandmaladaptiveselectionindevelopmentaldisorders-130514103634-phpapp02
The contribution of evolutionary psychology to the study of development and psychopathology depends on adherence to the principles of evolutionary biology. The human brain evolved because selection favored neither size nor complexity but instead the phenotypic plasticity supporting cognitive flexibility. Cell proliferation, migration, elongation, synaptogenesis, synaptic pruning, apoptosis, and myelination occur at varying rates during asynchronous phases of development throughout the brain. Developmentally sensitive periods result from phenotypic plasticity and are vital for adaptation to the environment. The biological systems surrounding the CYP19A1 gene provide mechanisms for neuroprotection and targeted neuronal debridement in response to environmental stress, uniting selection with developmental biology. Updates to Dunbar’s original hypothesis with current primatological data, inclusion of total brain mass, and the introduction of CYP19A1 orthology from nine primate species yields a linear regression, R2 = .994, adjusted R2 = .989, F(3, 5) = 143.758, p < .001.]]>
The contribution of evolutionary psychology to the study of development and psychopathology depends on adherence to the principles of evolutionary biology. The human brain evolved because selection favored neither size nor complexity but instead the phenotypic plasticity supporting cognitive flexibility. Cell proliferation, migration, elongation, synaptogenesis, synaptic pruning, apoptosis, and myelination occur at varying rates during asynchronous phases of development throughout the brain. Developmentally sensitive periods result from phenotypic plasticity and are vital for adaptation to the environment. The biological systems surrounding the CYP19A1 gene provide mechanisms for neuroprotection and targeted neuronal debridement in response to environmental stress, uniting selection with developmental biology. Updates to Dunbar’s original hypothesis with current primatological data, inclusion of total brain mass, and the introduction of CYP19A1 orthology from nine primate species yields a linear regression, R2 = .994, adjusted R2 = .989, F(3, 5) = 143.758, p &lt; .001.]]> Tue, 14 May 2013 10:36:34 GMT /thinkpatrick/phenotypic-plasticity-cyp19a1-pleiotropy-and-maladaptive-selection-in-developmental-disorders thinkpatrick@slideshare.net(thinkpatrick) Phenotypic Plasticity, CYP19A1 Pleiotropy, and Maladaptive Selection in Developmental Disorders thinkpatrick The contribution of evolutionary psychology to the study of development and psychopathology depends on adherence to the principles of evolutionary biology. The human brain evolved because selection favored neither size nor complexity but instead the phenotypic plasticity supporting cognitive flexibility. Cell proliferation, migration, elongation, synaptogenesis, synaptic pruning, apoptosis, and myelination occur at varying rates during asynchronous phases of development throughout the brain. Developmentally sensitive periods result from phenotypic plasticity and are vital for adaptation to the environment. The biological systems surrounding the CYP19A1 gene provide mechanisms for neuroprotection and targeted neuronal debridement in response to environmental stress, uniting selection with developmental biology. Updates to Dunbar’s original hypothesis with current primatological data, inclusion of total brain mass, and the introduction of CYP19A1 orthology from nine primate species yields a linear regression, R2 = .994, adjusted R2 = .989, F(3, 5) = 143.758, p &lt; .001. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/phenotypicplasticitycyp19a1pleiotropyandmaladaptiveselectionindevelopmentaldisorders-130514103634-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> The contribution of evolutionary psychology to the study of development and psychopathology depends on adherence to the principles of evolutionary biology. The human brain evolved because selection favored neither size nor complexity but instead the phenotypic plasticity supporting cognitive flexibility. Cell proliferation, migration, elongation, synaptogenesis, synaptic pruning, apoptosis, and myelination occur at varying rates during asynchronous phases of development throughout the brain. Developmentally sensitive periods result from phenotypic plasticity and are vital for adaptation to the environment. The biological systems surrounding the CYP19A1 gene provide mechanisms for neuroprotection and targeted neuronal debridement in response to environmental stress, uniting selection with developmental biology. Updates to Dunbar’s original hypothesis with current primatological data, inclusion of total brain mass, and the introduction of CYP19A1 orthology from nine primate species yields a linear regression, R2 = .994, adjusted R2 = .989, F(3, 5) = 143.758, p &amp;lt; .001.
Phenotypic Plasticity, CYP19A1 Pleiotropy, and Maladaptive Selection in Developmental Disorders from J Patrick Malone
]]> 6170 13 https://cdn.slidesharecdn.com/ss_thumbnails/phenotypicplasticitycyp19a1pleiotropyandmaladaptiveselectionindevelopmentaldisorders-130514103634-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds document White http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Systems theory of autistogenesis /slideshow/systems-theory-of-autistogenesis/14444231 systemstheoryofautistogenesis-120924223808-phpapp02
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]]> Mon, 24 Sep 2012 22:38:04 GMT /slideshow/systems-theory-of-autistogenesis/14444231 thinkpatrick@slideshare.net(thinkpatrick) Systems theory of autistogenesis thinkpatrick <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/systemstheoryofautistogenesis-120924223808-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br>
Systems theory of autistogenesis from J Patrick Malone
]]> 2993 6 https://cdn.slidesharecdn.com/ss_thumbnails/systemstheoryofautistogenesis-120924223808-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds document White http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Early version of autistogenesis presentation - /slideshow/early-version-of-autistogenesis-presentation/9965344 autistogenesispresentationfinal-111031150307-phpapp01
This is the presentation of my systems theory of autistogenesis made at the Western Psychological Association, the Autism Society, and the American Psychological Association. Since that time, new information has continued to support this theoretical perspective and I am now moving into experimental studies to confirm.]]>
This is the presentation of my systems theory of autistogenesis made at the Western Psychological Association, the Autism Society, and the American Psychological Association. Since that time, new information has continued to support this theoretical perspective and I am now moving into experimental studies to confirm.]]> Mon, 31 Oct 2011 15:03:05 GMT /slideshow/early-version-of-autistogenesis-presentation/9965344 thinkpatrick@slideshare.net(thinkpatrick) Early version of autistogenesis presentation - thinkpatrick This is the presentation of my systems theory of autistogenesis made at the Western Psychological Association, the Autism Society, and the American Psychological Association. Since that time, new information has continued to support this theoretical perspective and I am now moving into experimental studies to confirm. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/autistogenesispresentationfinal-111031150307-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> This is the presentation of my systems theory of autistogenesis made at the Western Psychological Association, the Autism Society, and the American Psychological Association. Since that time, new information has continued to support this theoretical perspective and I am now moving into experimental studies to confirm.
Early version of autistogenesis presentation - from J Patrick Malone
]]> 1533 5 https://cdn.slidesharecdn.com/ss_thumbnails/autistogenesispresentationfinal-111031150307-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation White http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-thinkpatrick-48x48.jpg?cb=1545027611 I have enjoyed time with the sign language competent chimpanzees at the Chimpanzee and Human Communication Institute in Ellensburg, Washington, and recently completed a study at the National Chimpanzee Sanctuary System, Chimp Haven, where I examined behavioral change and habitat usage due to cold weather, and performed the statistical analysis for this and two prior research efforts. I currently serve in the roll of chimpanzee therapist, working with the only chimpanzee to receive an autism diagnosis, Elia, at the Jeunes Animaux Confisques au Katanga (JACK), a chimpanzee sanctuary in the Lubumbashi Zoo, Democratic Republic of Congo. waldenu.academia.edu/JPatrickMalone https://cdn.slidesharecdn.com/ss_thumbnails/phenotypicplasticitycyp19a1pleiotropyandmaladaptiveselectionindevelopmentaldisorders-130514103634-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds thinkpatrick/phenotypic-plasticity-cyp19a1-pleiotropy-and-maladaptive-selection-in-developmental-disorders Phenotypic Plasticity,... https://cdn.slidesharecdn.com/ss_thumbnails/systemstheoryofautistogenesis-120924223808-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/systems-theory-of-autistogenesis/14444231 Systems theory of auti... https://cdn.slidesharecdn.com/ss_thumbnails/autistogenesispresentationfinal-111031150307-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/early-version-of-autistogenesis-presentation/9965344 Early version of autis...