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drug delivery formulation oral drug delivery solid form controlled release drug drug design solubility amorphous bioavailability nanosuspension modified preclinical pharmaceutical biotech hot melt extrusion nano particle parenteral transdermal ocular biotechnology cocrystal pharma formulation screening stability synchrotron reputation crisis pr public relations development biowaver biosimilar bioequivalence clinical development generic pkpd ba/be ivivc analytical cro permeable regulatory soluble supersaturation