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際際滷 1: Anthelmintics
Drugs that expel parasitic worms (helminths) from the body.
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According to Spectrum
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Broad Spectrum: Effective against multiple types.
According to Action
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Praziquantel Flukes, tapeworms
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History
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Mechanism: Prodrug prontosil converts to sulfanilamidethe active antibacterial agent.
Developments: Led to drugs like sulfapyridine (1938), sulfacetamide (1941), etc.
鏝 Chemistry
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Solubility increases in alkaline pH.
Structural Designations: N4 (para-amino), N1 (sulfonamide NH).
N1 substitution: systemic action; N4: gut action.
И StructureActivity Relationship (SAR)
Sulphanilamide core is essential.
N4 amino group = modifiable (for prodrugs).
Activity depends on:
Substitution at N1
Unsubstituted benzene ring
Para-positioned amino group
Electron-donating heterocycles activity
Classification
Based on Duration:
Extra-long acting: Sulphasalazine, Sulphalene
Long acting: Sulphadoxine, Sulphamethoxydiazine
Intermediate: Sulphamethoxazole
Short acting: Sulphamethiazole
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N1 & N4-substituted: Succinyl sulphathiazole
Miscellaneous: Mefenide sodium
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Block dihydropteroate synthase inhibit DNA/RNA synthesis in bacteria.
Uses
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IBD: Sulfasalazine
Burns: Silver sulfadiazine
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Format: PowerPoint Presentation.pptx
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Institution:Debark University
Published: 20 May 2025
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Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
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Age and Gender
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Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).AI Trends in Creative Operations 2024 by Artwork Flow.pdf
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History
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Mechanism: Prodrug prontosil converts to sulfanilamidethe active antibacterial agent.
Developments: Led to drugs like sulfapyridine (1938), sulfacetamide (1941), etc.
鏝 Chemistry
Amphoteric compounds, weak acids (pKa: 4.798.56).
Solubility increases in alkaline pH.
Structural Designations: N4 (para-amino), N1 (sulfonamide NH).
N1 substitution: systemic action; N4: gut action.
И StructureActivity Relationship (SAR)
Sulphanilamide core is essential.
N4 amino group = modifiable (for prodrugs).
Activity depends on:
Substitution at N1
Unsubstituted benzene ring
Para-positioned amino group
Electron-donating heterocycles activity
Classification
Based on Duration:
Extra-long acting: Sulphasalazine, Sulphalene
Long acting: Sulphadoxine, Sulphamethoxydiazine
Intermediate: Sulphamethoxazole
Short acting: Sulphamethiazole
Injectables: Sulphadiazine, Sulphamethoxine
Based on Structure:
N-substituted: Sulphadiazine, Sulphacetamide
N4-substituted (Prodrugs): Prontosil
N1 & N4-substituted: Succinyl sulphathiazole
Miscellaneous: Mefenide sodium
鏝 Mechanism of Action (MOA)
Structural analogs of PABA, inhibit folic acid synthesis.
Block dihydropteroate synthase inhibit DNA/RNA synthesis in bacteria.
Uses
Infections: UTIs, dysentery, burns, conjunctivitis, meningitis, malaria.
Special cases:
IBD: Sulfasalazine
Burns: Silver sulfadiazine
Malaria: Sulfadoxine + Pyrimethamine (resistant P. falciparum)
К Folate Reductase Inhibitors
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Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying its good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation thats least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state theyre comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).AI Trends in Creative Operations 2024 by Artwork Flow.pdf
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Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.Skeleton Culture Code
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Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.PEPSICO Presentation to CAGNY Conference Feb 2024
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PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.Content Methodology: A Best Practices Report (Webinar)
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This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.How to Prepare For a Successful Job Search for 2024
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The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.Social Media Marketing Trends 2024 // The Global Indie Insights
Social Media Marketing Trends 2024 // The Global Indie InsightsKurio // The Social Media Age(ncy)
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A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Desh辿 M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy lvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho Gonz叩lez, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplyt, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Sohnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).Trends In Paid Search: Navigating The Digital Landscape In 2024
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
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The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
Its important that youre ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
Youll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If youre looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.5 Public speaking tips from TED - Visualized summary
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From their humble beginnings in 1984, TED has grown into the worlds most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, its no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article 5 Public-Speaking Tips TED Gives Its Speakers, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9bChatGPT and the Future of Work - Clark Boyd 
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
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Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage. Getting into the tech field. what next 
Getting into the tech field. what next Tessa Mero
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The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.Google's Just Not That Into You: Understanding Core Updates & Search Intent
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
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1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.How to have difficult conversations 
How to have difficult conversations Rajiv Jayarajah, MAppComm, ACC
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Stop putting off having difficult conversations. Seven practical tips to ensure your next difficult conversation go smoothly. Introduction to Data Science
Introduction to Data ScienceChristy Abraham Joy
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A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.Time Management & Productivity - Best Practices
Time Management & Productivity - Best PracticesVit Horky
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Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.The six step guide to practical project management
The six step guide to practical project managementMindGenius
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The six step guide to practical project management
If you think managing projects is too difficult, think again.
Weve stripped back project management processes to the
basics to make it quicker and easier, without sacrificing
the vital ingredients for success.
If youre looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.
Dr Andrew Makar, Tactical Project ManagementBeginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...RachelPearson36
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A presentation for absolute beginners who have never touched TikTok and may be a bit scared of it!Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
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During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
Learn how to use ChatGPT to add AI power to your testing and test automation
Understand the limitations of the technology and where human expertise is crucial
Gain insight into different AI-based tools
Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.12 Ways to Increase Your Influence at Work
12 Ways to Increase Your Influence at WorkGetSmarter
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To succeed in your career, you need a strategy for sending out ripples of influence. Here are 12 ways you can start doing just that. ChatGPT webinar slides
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The document discusses various AI tools from OpenAI like GPT-3 and DALL-E 2, as well as ChatGPT. It explores how search engines are using AI and things to consider around AI-generated content. Potential SEO uses of ChatGPT are also presented, such as generating content at scale, conducting topic research, and automating basic coding tasks. The document encourages further reading on using ChatGPT for SEO purposes.Ad