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M.A. Sem - 2 | Presentation
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Paper - 110A: History of English Literature From 1900 to 2000
Submitted Date: April 1, 2025
Paper Name: History of English Literature From 1900 to 2000
Topic: Shadows and Light: Exploring Expressionism in The Cabinet of Dr.油Caligari and Nosferatu: A Symphony of Horror
[Please copy the link and paste it into any web browser to access the content.]
Video Link: https://youtu.be/pWjHqo6clT4
For a more in-depth discussion of this presentation, please visit the full blog post at the following link:
Please visit this blog to explore additional presentations from this season:
Hashtags:
#GermanExpressionism #SilentHorror #Caligari #Nosferatu #Chiaroscuro #VisualStorytelling #FilmHistory #HorrorCinema #CinematicArt #ExpressionistAesthetics
Keyword Tags:
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In Drug Metabolism is the process of converting a drug into product or inert substances after or before reaching at the site of action.
Metabolism plays an important role in elimination of drugs and foreign substance from the body.
The metabolism of any drug is generally characterised by two phases of reaction
1.Metabolic transformation ( biotransformation ) and
2.Conjugation
The Principal site of drug metabolism is the liver, but the kidney, lungs, and GIT also are important metabolic sites.
The enzymatic bio transformations of drugs is known as Drug Metabolism. Because many drugs have structures similar to those of endogenous compounds , drugs may get metabolised by specific enzymes for the related natural substrates as well as by non-specific enzymes.
Reaction type of Phase-I:
1.Oxidation
2.Reduction
3.Hydrolysis
Most drugs are metabolised ,atleast to some extent , by both phases of metabolism.
Example: Metabolism of Aspirin
Acetyl Salicylic acid undergoes hydrolysis to salicylic acid ( metabolic transformation ), which is then conjugated with glycine to form Salicyluric acid ( Conjugation ).
In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
1.Glucuronic acid
2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
9.Amino Acid Conjugation
10.Fatty Acid and Cholesterol Conjugation
Drug design is the process of creating new drugs by using knowledge of a biological target.
Drug design considers metabolism to optimize pharmaco kinects ( ADME: Absorption , Distribution , Metabolism , Excretion )
Cytochrome CYP450 enzyme in Drug Metabolism is vital in drug design to enhance efficacy , reduce toxicity and improve bioavailability.
Cytochrome P450 enzymes (CYPs) are a superfamily of heme -containing proteins found from bacteria to human.
Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
Adrenal and Skin and they shows the relative activity with repect to their organs in the process of drug metabolism.
Most important CYP450 enzymes are CYP1A2 , CYP2C9 , CYP2E1
,etc...
Toxic Effects of Drug Metabolism
Toxicity: Accumulation of Excess of medications in the Blood Stream.
Ariens (1948) and Mitchell and Horning (1984) deal with this topic.
Some examples of Metabolism-Linked Toxicity are
1.Acetaminophen (paracetmol)
2.Isoniazid ( TB drug)
3.Chloroform
4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
8.Tamoxifen (Breast Cancer drug )
9.Clozapine(Antipsychotic)
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CURRENT CASE COUNT: 880
Texas: 729 (+5) (56% of cases are in Gaines County)
New Mexico: 78 (+4) (83% of cases are from Lea County)
Oklahoma: 17
Kansas: 56 (38.89% of the cases are from Gray County)
HOSPITALIZATIONS: 103
Texas: 94 - This accounts for 13% of all cases in the State.
New Mexico: 7 This accounts for 9.47% of all cases in New Mexico.
Kansas: 2 - This accounts for 3.7% of all cases in Kansas.
DEATHS: 3
Texas: 2 This is 0.28% of all cases
New Mexico: 1 This is 1.35% of all cases
US NATIONAL CASE COUNT: 1,076 (confirmed and suspected)
INTERNATIONAL SPREAD
Mexico: 1,753 (+198) 4 fatalities
Chihuahua, Mexico: 1,657 (+167) cases, 3 fatalities, 9 hospitalizations
Canada: 2518 (+239) (Includes Ontarios outbreak, which began November 2024)
Ontario, Canada: 1,795 (+173) 129 (+10) hospitalizations
Alberta, Canada: 560 (+55)
Things to keep an eye on:
Mexico: Three children have died this month (all linked to the Chihuahua outbreak):
An 11-month-old and a 7-year-old with underlying conditions
A 1-year-old in Sonora whose family is from Chihuahua
Canada:
Ontario now reports more cases than the entire U.S.
Albertas case count continues to climb rapidly and is quickly closing in on 600 cases.
Emerging transmission chains in Manitoba and Saskatchewan underscore the need for vigilant monitoring of under-immunized communities and potential cross-provincial spread.
United States:
North Dakota: Grand Forks County has confirmed its first cases (2), linked to international travel. The state total is 21 since May 2 (including 4 in Cass County and 2 in Williams County), with one hospitalization reported.
OUTLOOK: With the springsummer travel season peaking between Memorial Day and Labor Day, both domestic and international travel may fuel additional importations and spread. Although measles transmission is not strictly seasonal, crowded travel settings increase the risk for under-immunized individuals.Unit Kali NetHunter is the official Kali Linux penetration testing platform f...
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M.A. Sem - 2 | Presentation
Presentation Season - 2
Paper - 110A: History of English Literature From 1900 to 2000
Submitted Date: April 1, 2025
Paper Name: History of English Literature From 1900 to 2000
Topic: Shadows and Light: Exploring Expressionism in The Cabinet of Dr.油Caligari and Nosferatu: A Symphony of Horror
[Please copy the link and paste it into any web browser to access the content.]
Video Link: https://youtu.be/pWjHqo6clT4
For a more in-depth discussion of this presentation, please visit the full blog post at the following link:
Please visit this blog to explore additional presentations from this season:
Hashtags:
#GermanExpressionism #SilentHorror #Caligari #Nosferatu #Chiaroscuro #VisualStorytelling #FilmHistory #HorrorCinema #CinematicArt #ExpressionistAesthetics
Keyword Tags:
Expressionism, The Cabinet of Dr. Caligari, Nosferatu, silent film horror, film noir origins, German Expressionist cinema, chiaroscuro techniques, cinematic shadows, psychological horror, visual aestheticsHow to Add a Custom Menu, List view and FIlters in the Customer Portal Odoo 18
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In Drug Metabolism is the process of converting a drug into product or inert substances after or before reaching at the site of action.
Metabolism plays an important role in elimination of drugs and foreign substance from the body.
The metabolism of any drug is generally characterised by two phases of reaction
1.Metabolic transformation ( biotransformation ) and
2.Conjugation
The Principal site of drug metabolism is the liver, but the kidney, lungs, and GIT also are important metabolic sites.
The enzymatic bio transformations of drugs is known as Drug Metabolism. Because many drugs have structures similar to those of endogenous compounds , drugs may get metabolised by specific enzymes for the related natural substrates as well as by non-specific enzymes.
Reaction type of Phase-I:
1.Oxidation
2.Reduction
3.Hydrolysis
Most drugs are metabolised ,atleast to some extent , by both phases of metabolism.
Example: Metabolism of Aspirin
Acetyl Salicylic acid undergoes hydrolysis to salicylic acid ( metabolic transformation ), which is then conjugated with glycine to form Salicyluric acid ( Conjugation ).
In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
1.Glucuronic acid
2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
9.Amino Acid Conjugation
10.Fatty Acid and Cholesterol Conjugation
Drug design is the process of creating new drugs by using knowledge of a biological target.
Drug design considers metabolism to optimize pharmaco kinects ( ADME: Absorption , Distribution , Metabolism , Excretion )
Cytochrome CYP450 enzyme in Drug Metabolism is vital in drug design to enhance efficacy , reduce toxicity and improve bioavailability.
Cytochrome P450 enzymes (CYPs) are a superfamily of heme -containing proteins found from bacteria to human.
Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
Adrenal and Skin and they shows the relative activity with repect to their organs in the process of drug metabolism.
Most important CYP450 enzymes are CYP1A2 , CYP2C9 , CYP2E1
,etc...
Toxic Effects of Drug Metabolism
Toxicity: Accumulation of Excess of medications in the Blood Stream.
Ariens (1948) and Mitchell and Horning (1984) deal with this topic.
Some examples of Metabolism-Linked Toxicity are
1.Acetaminophen (paracetmol)
2.Isoniazid ( TB drug)
3.Chloroform
4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
8.Tamoxifen (Breast Cancer drug )
9.Clozapine(Antipsychotic)
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References for this topic also mentioned at the end.Decision Tree-ID3,C4.5,CART,Regression Tree
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油
CURRENT CASE COUNT: 880
Texas: 729 (+5) (56% of cases are in Gaines County)
New Mexico: 78 (+4) (83% of cases are from Lea County)
Oklahoma: 17
Kansas: 56 (38.89% of the cases are from Gray County)
HOSPITALIZATIONS: 103
Texas: 94 - This accounts for 13% of all cases in the State.
New Mexico: 7 This accounts for 9.47% of all cases in New Mexico.
Kansas: 2 - This accounts for 3.7% of all cases in Kansas.
DEATHS: 3
Texas: 2 This is 0.28% of all cases
New Mexico: 1 This is 1.35% of all cases
US NATIONAL CASE COUNT: 1,076 (confirmed and suspected)
INTERNATIONAL SPREAD
Mexico: 1,753 (+198) 4 fatalities
Chihuahua, Mexico: 1,657 (+167) cases, 3 fatalities, 9 hospitalizations
Canada: 2518 (+239) (Includes Ontarios outbreak, which began November 2024)
Ontario, Canada: 1,795 (+173) 129 (+10) hospitalizations
Alberta, Canada: 560 (+55)
Things to keep an eye on:
Mexico: Three children have died this month (all linked to the Chihuahua outbreak):
An 11-month-old and a 7-year-old with underlying conditions
A 1-year-old in Sonora whose family is from Chihuahua
Canada:
Ontario now reports more cases than the entire U.S.
Albertas case count continues to climb rapidly and is quickly closing in on 600 cases.
Emerging transmission chains in Manitoba and Saskatchewan underscore the need for vigilant monitoring of under-immunized communities and potential cross-provincial spread.
United States:
North Dakota: Grand Forks County has confirmed its first cases (2), linked to international travel. The state total is 21 since May 2 (including 4 in Cass County and 2 in Williams County), with one hospitalization reported.
OUTLOOK: With the springsummer travel season peaking between Memorial Day and Labor Day, both domestic and international travel may fuel additional importations and spread. Although measles transmission is not strictly seasonal, crowded travel settings increase the risk for under-immunized individuals.Unit Kali NetHunter is the official Kali Linux penetration testing platform f...
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