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Allergy

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Mast cells undergo a process called degranulation when activated by allergens, releasing histamine and other chemicals from granules that cause inflammation. IgE antibodies attach to allergens in the body and bind to IgE receptors on mast cells, triggering the release of stored mediators like histamine as well as newly formed chemicals that prolong the inflammatory response.

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Allergy Degranulation Process
Allergy Activated mast cells go through a process called degranulation. They release histamine and other chemicals causing inflammation.
Allergy The antigen floats around the body
Allergy IgE antibod ies find allergen and attach themselves to it.
Allergy IgE binds to IgE receptors on surface of mast cells (a type of immune cell) This is a kind of FC receptor.
Allergy Stored mediators (4) such as histamine, proteases, chemokines and heparine are released from granules (5)
Allergy N ewly formed mediators also released (prostaglandins, leukotrienes, thromboxanes amd PAF)
Allergy Produced by Allergy-Details.com Material from Wikipedia Image by Pawe Ku添niar

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