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Biomatrica Fact Sheet May2009

M
Marylinn

Biomatrica offers technology to stabilize biological samples like DNA, RNA, proteins, cells and assays at room temperature. Their core technology allows for more efficient handling, storage and shipping of samples without degradation. Their products include solutions to preserve and store genomic material, RNA, bacterial cells and assays at room temperature for long periods of time. Biomatrica's technology addresses a large market for sample storage and could be expanded to new areas like protein stabilization and diagnostics.

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C O R P O R AT E F A C T S H E E T Ma y 2 0 0 9 C O M PA n y Ov E R v i E w Biomatrica, an innovative company focused on biostability, offers green technology to stabilize biological samples such as DNA, RNA, proteins, cells and assays at room temperature. Biomatricas core technology allows researchers and partners to be more efficient and secure by providing services and room-temperature handling, storage and shipping products that prevent the degradation of biological samples. Milestones: Opportunity 2004 The genomic age and development of high-throughput technologies has Biomatrica incorporates resulted in a vast pool of samples that require an integration of storage, Provisional patent application organization and analysis. Biological materials are primarily handled and 2005 stored in cold environments (4C, -20C, -80C and liquid nitrogen) which nitial round of financing I is costly. Additionally, problems during transport, storage and experimental obtained Expansion of patent filed design arise as even short-term storage of biological material at room D Sheriffs Crime Lab validates S temperature and repeated freeze/thaw cycles results in sample degradation DNAstable technology and loss of activity. 2006 Biomatricas technology is poised to create a paradigm shift in the biological ab and office opened, first L employee hired research industry and beyond, allowing the transition from cold to room year stability study completed 1 temperature storage and handling of biological samples. This will make at SD Sheriffs Crime Lab with sample storage and transport more consistent and reliable, ensure an excellent results ecologically sustainable process and maximize cost-effectiveness. aunch of DNAstable (DNA L storage) Products 2007 Stability Products aunch of CloneStable (bacterial L DNA storage) DNAstable速: Preserve and store genomic and plasmid DNA aunch of RNAstable L at room temperature for long-term storage. (RNA storage) RNAstable速: Preserve and store RNA samples at room temperature elease of SampleWare R for more than a year. 100% of the RNA can be recovered in 10 minutes Version 2.0 or less. trategic partnership formed S with Qiagen GMbH for DNA CloneStable速: Preserve and store unpurified bacterial genomic and storage plasmid DNA at room temperature for long-term storage. iomatrica launches DNA B CloneStab: Store and ship live E. coli samples at room temperature. Archive with DNA Direct 2008 Assays aunch of PCRboost L PCRboost 速: Enhance end-point and reverse transcription-PCR five-fold (amplification enhancer) or more during amplification of genomic DNA or RNA templates. elease of SampleWare R Version 3.0 STRboost: Improve STR multiplexing performance. chieved milestones for A RNAconcentrator: for concentrating dilute, aqueous RNA samples DNA stabilization in blood with strategic partner, Qiagen. to small volumes without sample loss. Second product licensed. aunch of CloneStab L Laboratory Management Software (live bacterial transport) SampleWare速: An easy-to-use, customizable database to store and aunch of RNAconcentrator L organize sample data. This is a tool that links with Biomatricas preservation (RNA product line) and storage platform. econd round financing S completed Biomatrica, Inc. 5627 Oberlin Drive, Suite 120 San Diego, CA 92121
Market Opportunities The addressable market size for sample storage is valued at US$34 Billion, which includes nucleic acid, protein, cell collection and storage as well as Management Team reagents, vaccine, diagnostic and screening applications. Judy Muller-Cohn, Ph.D. Founder, CEO Targets are scientific laboratories throughout the world that encompass Rolf Muller, Ph.D. the disciplines of molecular biology, cell biology, genomics, proteomics, Founder, President, CSO biochemistry and chemistry within universities, research institutes, Marylinn Munson biotechnology companies, pharmaceutical companies, medical facilities, Vice President, Business and governmental and forensics laboratories. Development Future products for the storage and transport market will include proteins Martin Latterich, Ph.D. (US$3 billion), viruses (US$7 billion) and cells (US$5 billion). Senior Director Research and Development Biomatricas technology can be expanded into a vast array of vertical markets such as: I) reagents, II) assay and processes, III) sequencing, IV) arrays, Board Of Directors V) diagnostics, VI) vaccine stabilization. Joe Markee Chairman Technology Biomatrica offers an innovative platform technology based on a proprietary Francois Ferre Director dissolvable sample matrix that shrink wraps biological material at room temperature. Its core technology is adapted from nature, using a molecular John Thompson mechanism called anhydrobiosis that enables organisms to survive droughts Director for over one hundred twenty years. A chemical mimic to anhydrobiosis was Judy Muller-Cohn developed to stabilize biological samples. Founder Rolf Muller intellectual Property Founder .S. and foreign patent applications filed with priority claim of our core U technology (dating to 2/04). Advisory Board dditional applications have been filed, directed at broad aspects of A Francois Ferre platform technology Founder, Althea Technologies. rademark applications filed and issued on the company name and T James Gautsch, Ph.D. key product names. Founder, former CEO of Bio 101, sold to Qbiogene. Awards 2006 The Most Innovative Product of the Year in the category of life science Jim Johnson reagents and tools for the first products from Connect, a globally recognized Former VP of Worldwide Commercial Operations for public benefits organization fostering entrepreneurship in San Diego. Invitrogen and Novex National Institute of Justice Grant to develop a Crime Scene Collection Kit for DNA John H. Crowe, Ph.D. Professor Emeritus UC Davis. Partnerships, Collaborations and Licensing Founder and former Director The Institute of Biostability In 2007 Biomatrica signed a license and supply partnership with Qiagen,the worldwide leader in DNA extraction and purification reagents for the DNA John Elder, Ph.D. SampleGard速 and the DNA portion of the SampleMatrix technology for Professor, distribution to end-users. Also in 2007, Biomatrica entered into a partnership The Scripps Research Institute with DNA Direct to produce the DNA Archive which is sold into the consumer John Thompson market for personalized DNA banking. Biomatrica has collaborated with Former Exec. VP of Corporate institutions such as the University of California system, the Scripps Research Strategy for Invitrogen Institute, the U.S. Navy, CalState LA, and the National Institute of Justice. Paul Bremner Founder and Former CEO, Financial VASci Software Company As a privately held company, Biomatrica commenced product sales in 2006 Sheldon Cohn, J.D., M.B.A. and partnerships in 2007. Profitability and a positive cash flow are projected CEO Budget National Finance in 2009 based on a product-based sales strategy and an active new Sheldon Engelhorn product release schedule for the next 5-7 years. Biomatrica has a worldwide Founder of Novex, distribution network covering Canada, Europe, and Asia. sold to Invitrogen Riccardo Pigliucci Contact Former President Perkin Elmer Marylinn Munson, Biomatrica Thomas Fitting, Ph.D., J.D. Vice President, Business Development Chief Patent Counsel, Tel: (858) 550-0308 ext. 233 Cell: (858) 336-1492 The Scripps Research Institute Email: mmunson@biomatrica.com Web: www.biomatrica.com 息2009 Biomatrica, Inc. All rights reserved.

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Biomatrica Fact Sheet May2009

  • 1. C O R P O R AT E F A C T S H E E T Ma y 2 0 0 9 C O M PA n y Ov E R v i E w Biomatrica, an innovative company focused on biostability, offers green technology to stabilize biological samples such as DNA, RNA, proteins, cells and assays at room temperature. Biomatricas core technology allows researchers and partners to be more efficient and secure by providing services and room-temperature handling, storage and shipping products that prevent the degradation of biological samples. Milestones: Opportunity 2004 The genomic age and development of high-throughput technologies has Biomatrica incorporates resulted in a vast pool of samples that require an integration of storage, Provisional patent application organization and analysis. Biological materials are primarily handled and 2005 stored in cold environments (4C, -20C, -80C and liquid nitrogen) which nitial round of financing I is costly. Additionally, problems during transport, storage and experimental obtained Expansion of patent filed design arise as even short-term storage of biological material at room D Sheriffs Crime Lab validates S temperature and repeated freeze/thaw cycles results in sample degradation DNAstable technology and loss of activity. 2006 Biomatricas technology is poised to create a paradigm shift in the biological ab and office opened, first L employee hired research industry and beyond, allowing the transition from cold to room year stability study completed 1 temperature storage and handling of biological samples. This will make at SD Sheriffs Crime Lab with sample storage and transport more consistent and reliable, ensure an excellent results ecologically sustainable process and maximize cost-effectiveness. aunch of DNAstable (DNA L storage) Products 2007 Stability Products aunch of CloneStable (bacterial L DNA storage) DNAstable速: Preserve and store genomic and plasmid DNA aunch of RNAstable L at room temperature for long-term storage. (RNA storage) RNAstable速: Preserve and store RNA samples at room temperature elease of SampleWare R for more than a year. 100% of the RNA can be recovered in 10 minutes Version 2.0 or less. trategic partnership formed S with Qiagen GMbH for DNA CloneStable速: Preserve and store unpurified bacterial genomic and storage plasmid DNA at room temperature for long-term storage. iomatrica launches DNA B CloneStab: Store and ship live E. coli samples at room temperature. Archive with DNA Direct 2008 Assays aunch of PCRboost L PCRboost 速: Enhance end-point and reverse transcription-PCR five-fold (amplification enhancer) or more during amplification of genomic DNA or RNA templates. elease of SampleWare R Version 3.0 STRboost: Improve STR multiplexing performance. chieved milestones for A RNAconcentrator: for concentrating dilute, aqueous RNA samples DNA stabilization in blood with strategic partner, Qiagen. to small volumes without sample loss. Second product licensed. aunch of CloneStab L Laboratory Management Software (live bacterial transport) SampleWare速: An easy-to-use, customizable database to store and aunch of RNAconcentrator L organize sample data. This is a tool that links with Biomatricas preservation (RNA product line) and storage platform. econd round financing S completed Biomatrica, Inc. 5627 Oberlin Drive, Suite 120 San Diego, CA 92121
  • 2. Market Opportunities The addressable market size for sample storage is valued at US$34 Billion, which includes nucleic acid, protein, cell collection and storage as well as Management Team reagents, vaccine, diagnostic and screening applications. Judy Muller-Cohn, Ph.D. Founder, CEO Targets are scientific laboratories throughout the world that encompass Rolf Muller, Ph.D. the disciplines of molecular biology, cell biology, genomics, proteomics, Founder, President, CSO biochemistry and chemistry within universities, research institutes, Marylinn Munson biotechnology companies, pharmaceutical companies, medical facilities, Vice President, Business and governmental and forensics laboratories. Development Future products for the storage and transport market will include proteins Martin Latterich, Ph.D. (US$3 billion), viruses (US$7 billion) and cells (US$5 billion). Senior Director Research and Development Biomatricas technology can be expanded into a vast array of vertical markets such as: I) reagents, II) assay and processes, III) sequencing, IV) arrays, Board Of Directors V) diagnostics, VI) vaccine stabilization. Joe Markee Chairman Technology Biomatrica offers an innovative platform technology based on a proprietary Francois Ferre Director dissolvable sample matrix that shrink wraps biological material at room temperature. Its core technology is adapted from nature, using a molecular John Thompson mechanism called anhydrobiosis that enables organisms to survive droughts Director for over one hundred twenty years. A chemical mimic to anhydrobiosis was Judy Muller-Cohn developed to stabilize biological samples. Founder Rolf Muller intellectual Property Founder .S. and foreign patent applications filed with priority claim of our core U technology (dating to 2/04). Advisory Board dditional applications have been filed, directed at broad aspects of A Francois Ferre platform technology Founder, Althea Technologies. rademark applications filed and issued on the company name and T James Gautsch, Ph.D. key product names. Founder, former CEO of Bio 101, sold to Qbiogene. Awards 2006 The Most Innovative Product of the Year in the category of life science Jim Johnson reagents and tools for the first products from Connect, a globally recognized Former VP of Worldwide Commercial Operations for public benefits organization fostering entrepreneurship in San Diego. Invitrogen and Novex National Institute of Justice Grant to develop a Crime Scene Collection Kit for DNA John H. Crowe, Ph.D. Professor Emeritus UC Davis. Partnerships, Collaborations and Licensing Founder and former Director The Institute of Biostability In 2007 Biomatrica signed a license and supply partnership with Qiagen,the worldwide leader in DNA extraction and purification reagents for the DNA John Elder, Ph.D. SampleGard速 and the DNA portion of the SampleMatrix technology for Professor, distribution to end-users. Also in 2007, Biomatrica entered into a partnership The Scripps Research Institute with DNA Direct to produce the DNA Archive which is sold into the consumer John Thompson market for personalized DNA banking. Biomatrica has collaborated with Former Exec. VP of Corporate institutions such as the University of California system, the Scripps Research Strategy for Invitrogen Institute, the U.S. Navy, CalState LA, and the National Institute of Justice. Paul Bremner Founder and Former CEO, Financial VASci Software Company As a privately held company, Biomatrica commenced product sales in 2006 Sheldon Cohn, J.D., M.B.A. and partnerships in 2007. Profitability and a positive cash flow are projected CEO Budget National Finance in 2009 based on a product-based sales strategy and an active new Sheldon Engelhorn product release schedule for the next 5-7 years. Biomatrica has a worldwide Founder of Novex, distribution network covering Canada, Europe, and Asia. sold to Invitrogen Riccardo Pigliucci Contact Former President Perkin Elmer Marylinn Munson, Biomatrica Thomas Fitting, Ph.D., J.D. Vice President, Business Development Chief Patent Counsel, Tel: (858) 550-0308 ext. 233 Cell: (858) 336-1492 The Scripps Research Institute Email: mmunson@biomatrica.com Web: www.biomatrica.com 息2009 Biomatrica, Inc. All rights reserved.