This document discusses methods for determining whether fragmented bone material is human or non-human. It outlines gross morphological differences visible to the naked eye, such as fused epiphyses in juvenile human long bones versus curved long bones in small mammals. Microscopic examination can reveal larger Haversian systems in human bone. Serological tests like precipitin reactions and collagen fingerprinting extract protein signatures to identify the species. DNA analysis of conserved mitochondrial RNA regions can also determine if a bone sample is human.