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DIABETES GESTASIONAL.pptx

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Rosyid Ridho
Rosyid Ridho

Gestational diabetes occurs when a pregnant woman's body is unable to produce enough insulin to meet increased demands during pregnancy. As pregnancy progresses, hormones cause insulin sensitivity to decrease and glucose levels to rise, which the pancreas normally compensates for with more insulin production. However, in gestational diabetes the pancreas is unable to produce enough additional insulin to keep blood glucose levels within the normal range.

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McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Prim [Internet]. 2019;5(1):47. Available from: https://doi.org/10.1038/s41572- 019-0098-8 During early pregnancy, increases in estrogens,progestins, and other pregnancy-related hormones lead to lower glucose levels, promotion of fat deposition, delayed gastric emptying, and increased appetite.
As gestation progresses, postprandial glucose levels steadily increase as insulin sensitivity steadily decreases. For glucose control it is necessary for maternal insulin secretion to increase sufficiently to counteract the fall in insulin sensitivity. GDM occurs when there is insufficient insulin secretion to counteract the pregnancy-related decrease in insulin sensitivity Plows, J., Stanley, J., Baker, P., Reynolds, C., & Vickers, M. (2018). The Pathophysiology of Gestational Diabetes Mellitus. International Journal of Molecular Sciences, 19(11), 3342. doi:10.3390/ijms19113342
DIABETES GESTASIONAL.pptx
DIABETES GESTASIONAL.pptx

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DIABETES GESTASIONAL.pptx

  • 2. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Prim [Internet]. 2019;5(1):47. Available from: https://doi.org/10.1038/s41572- 019-0098-8 During early pregnancy, increases in estrogens,progestins, and other pregnancy-related hormones lead to lower glucose levels, promotion of fat deposition, delayed gastric emptying, and increased appetite.
  • 3. As gestation progresses, postprandial glucose levels steadily increase as insulin sensitivity steadily decreases. For glucose control it is necessary for maternal insulin secretion to increase sufficiently to counteract the fall in insulin sensitivity. GDM occurs when there is insufficient insulin secretion to counteract the pregnancy-related decrease in insulin sensitivity Plows, J., Stanley, J., Baker, P., Reynolds, C., & Vickers, M. (2018). The Pathophysiology of Gestational Diabetes Mellitus. International Journal of Molecular Sciences, 19(11), 3342. doi:10.3390/ijms19113342