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Histology of Respiratory system
Chantha Jayawardena
DBS
10/11/10
Why should I learn..RS
Objectives
 Components
 Functions of each component
 Structural features (describe and draw) of
components including structure-function
relationship
 Identify (LM)
 Physiological aspect
 Clinical
Functions
Atmospheric air
RT
Dry
Full of dust
Functions
Atmospheric air
RT
Dry
Full of dust
Functions
Atmospheric air
RT
Dry
Full of dust
Components
Nose
Pharynx
Larynx
Upper respiratory tract
Components
 Divide
dichotomously with
decreasing
diameter
Trachea faculty.ksu.edu.sa
FOD. SL
Components
 Divide
dichotomously with
decreasing
diameter
 Changes takes
place gradually
faculty.ksu.edu.sa
FOD. SL
Components
Nasal cavity
Pharynx
Larynx
Trachea
Conducting portion
Respiratory portion
Conditioning air
 Adjustment
temperature
humidity
 Purification /cleaning
dust removal
Gas exchange
 Between blood and RP
Minimise damage
 Against foreign
particles
Structure including histology
Variations
 Epithelium (thickness, cilia, goblet cells)
 Lamina propria (LP)
 Submucosa (SM)
 Cartilage
 Smooth muscles
Nasal cavity
 Cartilages, bones, mucous membrane
 Chonchae (increase surface area and
turbulent airflow  increase contact
between air and MM)
 Hairs (vibrissae)  (trap large particles)
Nasal cavity
Histology of nasal cavity
 Respiratory epithelium (pseudostratified ciliated)
Vein
Vein
Vein
Vein
Epithelium
Bone
Lamina propria
Veins ; Swell bodies
http://www.lab.anhb.uwa.edu.au
Histology of nasal cavity
 Respiratory epithelium (pseudostratified ciliated)
Mag
Mag
Vein
Vein
Vein
Vein
Epithelium
Bone
* *
Lamina propria
http://www.lab.anhb.uwa.edu.au
Pharynx and Larynx
 Cartilages and muscles
 Mucous membrane
 Epithelium
 (Pseudostratified
-Respiratory side
 (Stratified squamous
Food/ oral side)
Epiglottis - Histology
 Elastic cartilage and mucous
membrane
Mag
http://www.lab.anhb.uwa.edu.au
Trachea
 Hyaline cartilage & smooth
muscle
 16-20 C shaped rings
(support)
 Smooth muscle (trachealis)
bridge open ends
posteriorly (control DM)
 Between rings-
fibroelastic tissue (allow
expansion)
www.kgu.de
Trachea - histology
Mag
Lamina propria
Epithelium
Submucosa
Cartilage
http://www.lab.anhb.uwa.edu.au
Trachea - histology
Mag
Lamina propria
Epithelium
Submucosa
Cartilage
http://www.lab.anhb.uwa.edu.au
Trachea - histology
Mag
Lamina propria
Epithelium
Submucosa
Cartilage
http://www.lab.anhb.uwa.edu.au
Trachea
 Draw and label
Principal / primary / main bronchi -
histology
 Epithelium similar to trachea (goblet cells )
 Cartilages  interconnected plates
 Smooth muscles beneath the LP
 Submucosa  seromucous glands
Bronchi - histology
 Diameter decreases
 Epithelium similar to trachea
 Shape and arrangement of the cartilage and
smooth muscle are different
 With decrease of DM  Cartilage ring become
irregular isolated plates
 Smooth muscles in the LP are spirally arranged
 Lymphocytes & lymphoid aggregations in the LP
Segmental / Tertiary bronchi
 Epithelium  less stratified, less goblet
cells
 Smooth muscles prominent in the LP
 Less submucosa and seromucous
glands
 Few isolated cartilage plates
Segmental / Tertiary bronchi
http://www.lab.anhb.uwa.edu.au
Bronchus
Segmental / Tertiary bronchi
http://www.lab.anhb.uwa.edu.au
Segmental / Tertiary bronchi
 Draw and label
Bronchioles
Bronchioles
http://www.lab.anhb.uwa.edu.au
Bronchioles
 Draw and label
Respiratory bronchiloes
 Sac like alveoli along the wall
 Epithelium  ciliated cuboidal
 No goblet cells, Clara cells present
 No cartilage
 Little smooth muscle in the LP
 No submucosa
Alveolar duct and alveoli
 Exchange of gas
 Epithelium simple squamous
 Elastic and reticulin fibers  elastic recoil & prevent
over expansion
 Smooth muscles only at the openings of alveloar
ducts
 Cigarette smoking  break down alveolar tissue and
impair repair of tissue - emphysema
Alveolar duct and alveoli
 Cells become very thin for gas
exchange
 Several cell types
 Squamous alveolar cells (Type I)  97 %
 Desmosomes & tight junctions present -
prevent leakage of tissue fluid
Alveolar duct and alveoli
 Surfactant secreting cells (Type II) 3 % -
reduce surface tension
 Round cells
 Can proliferate & produce new type I & II cells
 Respiratory distress syndrome  Immature baby
http://www.lab.anhb.uwa.edu.au
Alveolar duct and alveoli
 Alveolar macrophages  interalveolar septum,
surface of alveoli
http://www.lab.anhb.uwa.edu.au
Alveoli and blood-gas barrier
 Epithelium of alveoli & capillaries become
very thin
 Basement membrane of two epithelia fused each
other  thin barrier
Blood-gas barrier
 Draw and label
Trachea Bronchus Bronchiole Alveoli
Epithelium
Lamina
propria
Submucosa
cartilage
Thickness of
epithelium
Cilia
Goblet cells
Smooth muscle
Cartilage
Sero-mucous
glands
Function
Trachea Bronchus Bronchiole Alveoli
References
http://www.lab.anhb.uwa.edu.au//

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