Homology modelling
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Just something I did for leisure :) .You need to download PDB viewer, Yasara/Accelerys for a clear understanding of this subject.
Homology modelling
- 1. by Elda Nurafnie binti Ibnu Rasid
- 2. Able to define Homology modeling Understand the basic steps of Homology modeling
- 3. Homologous proteins Portion of 2 proteins with similar amino acids : Conserved Region Highly similar proteins may have same basic function Homology Modeling Comparative modeling of protein To predict protein structure based on known 3D shape protein as the template
- 4. TEMPLATE ? UNKNOWN STRUCTURE SEQUENCE ALIGNMENT STRUCTURAL MODEL STRUCTURAL MODEL
- 6. 1. To look for homologous protein 2. To search for template
- 12. CPHmodel EsyPred3D SWISS-MODEL
- 14. Swiss-PdbViewer 4.1 YASARA Accelrys DS Viewer 5.0
- 15. PDB Viewer
- 16. YASARA
- 17. Verification of Model Verify3D Errat Plot Ramachandran Plot
- 18. http://blast.ncbi.nlm.nih.gov/ http://www.ebi.ac.uk/Tools/msa/clustalw2/ http://www.yasara.org/ http://spdbv.vital-it.ch/download.html http://swissmodel.expasy.org/ http://nihserver.mbi.ucla.edu/ERRATv2/ http://nihserver.mbi.ucla.edu/Verify_3D/