The use of serialization as an anti-counterfeiting measure has expanded across the world, and across sectors. This is especially true in the pharmaceutical sector, where more than 75% of the worlds pharmaceutical supply will be under serialization regulations by 2020. The United States, the European Union, Argentina, Turkey, Saudi Arabia, India and Russia, amongst others, already have or are in the process of implementing regulations. Several other countries are evaluating how best to protect their patients against the scourge of counterfeiting, one that takes hundreds of thousands of lives a year and causes billions of dollars of losses to industry (one estimate by the World Economic Forum put it at $200 bn annually ). Even without regulations, leading companies around the world are adopting serialization as a tool to protect their brands and secure their supply chains. Whether you are a brand owner or a regulator, taking those first steps in the serialization journey can be daunting. The article is an attempt to break it down into five steps view as being essential for success.