Ultrasonic nebulizers can increase temperature during treatment and are not suitable for suspensions. Breath-actuated nebulizers only generate aerosol during inspiration. New soft mist inhalers and vibrating mesh devices produce low-velocity aerosols between 2.2-5.5 亮m for effective drug delivery while being portable.
21. Ultrasonic Nebulizers
The temperature can rise 10-15属C over a
10- minute treatment period, which may
adversely affect heat-sensitive
components of formulations
Ultrasonic nebulizers also are not suitable
for nebulizing suspensions
22. Breath-Actuated Nebulizers
generate aerosol only during inspiration
New-generation nebulizers Soft Mist
Inhalers
uses mechanical energy to create an
aerosol with a low-velocity spray
aerosol ranges 2.2-5.5 亮m MMD Middleton
8th edition
23. Vibrating Mesh Devices:
Passive generate aerosol only during
inspiration Vibrating Mesh Devices
Active vibrates at a high frequency
high FPFs and very low dead volumes
battery-operated