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Pathomorphology

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Smoking has a long history dating back 5000 years to religious rituals among ancient civilizations like Babylonians, Indians, and Chinese. While initially used ceremonially, smoking was later adopted for pleasure or social purposes. Substances like cannabis, ghee, and incense have been smoked for at least 2000 years using pipes or chillums. The document then presents research on the effects of parental smoking on offspring in rats. It finds smoking parents leads to damaged blood vessel endothelium and hyperproliferation in offspring, with implications for earlier vascular disease risk.

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Pathomorphology
The history of smoking It dates back to as early as 5000 BC in shamanistic rituals. Many ancient civilizations, such as the Babylonians, Indians and Chinese, burnt incense as a part of religious rituals, as did the Israelites and the later Catholic and Orthodox Christian churches. Smoking in the Americas probably had its origins in the incense-burning ceremonies of shamans but was later adopted for pleasure, or as a social tool. The smoking of tobacco, as well as various hallucinogenic drugs, was used to achieve trances and to come into contact with the spirit world. Substances such as Cannabis, clarified butter (ghee), fish offal, dried snake skins and various pastes molded around incense sticks dates back at least 2000 years. Fumigation (dhupa) and fire offerings (homa) are prescribed in the Ayurveda for medical purposes, and have been practiced for at least 3,000 years while smoking, dhumrapana (literally "drinking smoke"), has been practiced for at least 2,000 years. Before modern times these substances have been consumed through pipes, with stems of various lengths or chillums
Pathomorphology
Pathomorphology
To prove how hazardous smoking can be, not only in adult humans but also intra-uterinally in fetus.
Materials and Methods: Investigation done with the help of a microscope and slides IHCh reaction for 8 factor (is localized in endotheliocytes). Procedure: The experiment was started 1 month prior pairing. 4 of pairs of rats Wistar were taken into consideration – 1st: controlled (nonsmoking); 2nd: mother- smoker, father- nonsmoker; 3rd: father - smoker, mother - nonsmoker; 4th both were smokers. The smokers were kept in special box for passive smoking for 15 mins every day, with the usage of ½ a cigarette. Brain of newborn rats was taken in study. Morphometry was made: calculation of capillaries amount in the cortex of parietal lobe.
Pathomorphology
17 44 50 31 CONTROLLED SMOKING FATHER SMOKING MOTHER BOTH SMOKERS Capillarychanges Smokers
Pathomorphology
Results of Research: The capillaries in the brain of main groups animals are dilated due to desquamation of endothelium whereas in controlled animals such phenomenon is absent. The result of the number of capillaries on the cross section of 0.02mm2 showed the average of capillaries amount as follows: controlled - 17, smoking mother- 50, smoking father- 44, both smokers- 31. As an explanation of the received result it is possible to assume as a direct trans-placental action of products of burning of tobacco, and epigenetic influences. It is obvious that in utero, in the main groups endothelium of capillaries perishes more intensively than in control animals. Therefore, possibly they have a higher level of VEGF. Therefore, as a result - a more developed capillary network. It is the reaction of adaptation to existence in a smoking environment. Simultaneously in the main groups endothelium more easily destructed. The smoker’s babies had smaller brains with less grey and white matter and were at greater risk of stress and anxiety & could contribute to SIDS. Nicotine may be poisonous to area of the brain directly involved with heart and breathing functions and arousal from sleep.
Pathomorphology
Pathomorphology
Every time an individual smokes, the blood gets thicker and dirty with toxins
Pathomorphology
Pathomorphology
Low birth weight Miscarriages Still birth Birth defects
Smoking of parents leads to damage to the endothelium of blood capillaries in offspring. At the beginning of life this is compensated by hyperproliferation of the endothelium. Possibilities of proliferation of any cells are limited. We can expect an earlier development of vascular diseases in descendants of smokers’ parents.
Smoking leaves an unseen scar, it fills us with toxins and tar. Maybe, it’s time we tar our roads and not our organs, I am sure we can be brighter, to put down that lighter and move towards a healthier and happier cosmos. and put it out, before it puts us out!
Pathomorphology

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Pathomorphology

  • 2. The history of smoking It dates back to as early as 5000 BC in shamanistic rituals. Many ancient civilizations, such as the Babylonians, Indians and Chinese, burnt incense as a part of religious rituals, as did the Israelites and the later Catholic and Orthodox Christian churches. Smoking in the Americas probably had its origins in the incense-burning ceremonies of shamans but was later adopted for pleasure, or as a social tool. The smoking of tobacco, as well as various hallucinogenic drugs, was used to achieve trances and to come into contact with the spirit world. Substances such as Cannabis, clarified butter (ghee), fish offal, dried snake skins and various pastes molded around incense sticks dates back at least 2000 years. Fumigation (dhupa) and fire offerings (homa) are prescribed in the Ayurveda for medical purposes, and have been practiced for at least 3,000 years while smoking, dhumrapana (literally "drinking smoke"), has been practiced for at least 2,000 years. Before modern times these substances have been consumed through pipes, with stems of various lengths or chillums
  • 5. To prove how hazardous smoking can be, not only in adult humans but also intra-uterinally in fetus.
  • 6. Materials and Methods: Investigation done with the help of a microscope and slides IHCh reaction for 8 factor (is localized in endotheliocytes). Procedure: The experiment was started 1 month prior pairing. 4 of pairs of rats Wistar were taken into consideration – 1st: controlled (nonsmoking); 2nd: mother- smoker, father- nonsmoker; 3rd: father - smoker, mother - nonsmoker; 4th both were smokers. The smokers were kept in special box for passive smoking for 15 mins every day, with the usage of ½ a cigarette. Brain of newborn rats was taken in study. Morphometry was made: calculation of capillaries amount in the cortex of parietal lobe.
  • 8. 17 44 50 31 CONTROLLED SMOKING FATHER SMOKING MOTHER BOTH SMOKERS Capillarychanges Smokers
  • 10. Results of Research: The capillaries in the brain of main groups animals are dilated due to desquamation of endothelium whereas in controlled animals such phenomenon is absent. The result of the number of capillaries on the cross section of 0.02mm2 showed the average of capillaries amount as follows: controlled - 17, smoking mother- 50, smoking father- 44, both smokers- 31. As an explanation of the received result it is possible to assume as a direct trans-placental action of products of burning of tobacco, and epigenetic influences. It is obvious that in utero, in the main groups endothelium of capillaries perishes more intensively than in control animals. Therefore, possibly they have a higher level of VEGF. Therefore, as a result - a more developed capillary network. It is the reaction of adaptation to existence in a smoking environment. Simultaneously in the main groups endothelium more easily destructed. The smoker’s babies had smaller brains with less grey and white matter and were at greater risk of stress and anxiety & could contribute to SIDS. Nicotine may be poisonous to area of the brain directly involved with heart and breathing functions and arousal from sleep.
  • 13. Every time an individual smokes, the blood gets thicker and dirty with toxins
  • 16. Low birth weight Miscarriages Still birth Birth defects
  • 17. Smoking of parents leads to damage to the endothelium of blood capillaries in offspring. At the beginning of life this is compensated by hyperproliferation of the endothelium. Possibilities of proliferation of any cells are limited. We can expect an earlier development of vascular diseases in descendants of smokers’ parents.
  • 18. Smoking leaves an unseen scar, it fills us with toxins and tar. Maybe, it’s time we tar our roads and not our organs, I am sure we can be brighter, to put down that lighter and move towards a healthier and happier cosmos. and put it out, before it puts us out!