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PENICILLIN
DR VISHAL DEEP (PT)
PHYSIOTHERAPY INCHARGE
GMCH,MIRAJ
Introduction
 Antibiotic: Any substance that inhibits the growth and replication of a bacterium
or kills it outright.
 Penicillin:Obtained from Fungus Penicillium Chrysogenum
 Discovered by Sir Alexander Fleming in 1928.
 One of the most important group of antibiotics.
Mechanism of Action
Penicillin
Bind (PBP) on the cell wall of susceptible bacteria
Inhibits transpeptidation
Prevents peptidoglycan synthesis
Cell wall deficient forms spheroplasts & filamentous forms
Autolysis
Cell death (bactericidal action)
Classification
Penicillin
Natural Semi Synthetic
Penicillin G
(Benzyl Penicillin)
Semi Synthetic
Acid Resistant Penicillase Resistant Beta Lactamase Extended Spectrum
-Penicillin V - Methicillin - Tazobactum
- Cloxacillin - Clavulanic Acid
Aminopenicillin Carboxypenicillin Ureidopenicillin
- Ampicillin -Carbenicillin -Piperacillin
- Amoxicillin
Theraputic uses
1. Streptococcal Infection
 Pharyngitis
 Scarlett Fever
 Rheumatic Fever
 Endocarditis
2. Pneumococcal Infection
 Lobar Pneumonia
3. Meningcoccal Infection
 Menengitis
4. Gonococcal Infection
 Opthalmia Neonatorum
5. Syphillis
 Drug of Choice
6. Leptospirosis
7. Anaerobic Infection
 Pulmonary Infection and Brain Abscess
8. Tetanus and Gas Gangrene
 Gas Gangrene Treatment of Choice
Adverse Effect
1. Local Injury and Direct Toxicity
 Pain at injection site
 Nausea
 Shivering
 Fever
 Myalgia
2. Hypersensitivity
 1-10%
 Allergic to drugs
 Rash,Itching,Fever
 Anaphylaxis
3. Bleeding
 Due to interference in platelet function
4. Brain Toxicity
 Mental Confusion
 Muscular Twitching
 Convulsions
 Coma
Doubts
Thank You

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