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This document discusses nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used over-the-counter and prescription pain relievers that work by inhibiting inflammation. Some common examples are aspirin, ibuprofen, and acetaminophen. The document outlines several general contraindications for NSAID use, such as kidney, liver, heart, or stomach problems. It then provides more specific contraindications for some common NSAIDs like aspirin, paracetamol, indomethacin, ibuprofen, and diclofenac sodium.

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COX inhibitors Nonsteroidal anti- inflammatory drugs Nonopioid analgesics Nirmal Raj Marasine CMC E-mail- Nirmalrajmarasine@gmai.com
A therapeutic agent which relieves pain and fever by inhibiting the inflammatory response. These drugs are available over the counter and by prescription. Some common examples include aspirin, ibuprofen, indomethacin, and less commonly acetaminophen (Tylenol).
MOA
GENERAL CONTRAINDICATION Dont use in the: kidney problems, liver problems, stomach problems (e.g., ulcers), heart disease (e.g., arrhythmias, heart failure), high blood pressure (hypertension), diabetes, blood problems (e.g., anemia, bleeding disorders, porphyria),asthma, nasal polyps, eye problems, severe or long-lasting headaches, any allergies - especially aspirin/NSAID allergy (e.g., ibuprofen, celecoxib). This drug may make you dizzy or drowsy. Use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages
This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, use a sunscreen, and wear protective clothing when outdoors. This medicine may cause stomach bleeding. Daily use of alcohol and this medicine may increase your risk for stomach bleeding. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Using this drug during the last 6 months of pregnancy is not recommended. This drug may pass into breast milk. Consult your doctor before breast-feeding
if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine for pain right before or after heart bypass surgery
Aspirin contraindications peptic ulcer bleeding disorder hypersensitivity to nsaids under <12 children liver disease pregnancy and lactation chickenpox or influenza infection
Paracetamol(acetoaminophen) contraindication liver disease (eg,jaundice)
indomethacin Contraindication machinery operators Drivers Psychiatric patients Epileptics Kidney disease Pregnant women children
ibuprofen Contraindications peptic ulcer Lactting mother Pregnancy Hypersensitivity Unknown bleeding Children under seven
Diclofenac sodium Contraindication Peptic ulcer Children under seven years Kidney and liver disease

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  • 1. COX inhibitors Nonsteroidal anti- inflammatory drugs Nonopioid analgesics Nirmal Raj Marasine CMC E-mail- Nirmalrajmarasine@gmai.com
  • 2. A therapeutic agent which relieves pain and fever by inhibiting the inflammatory response. These drugs are available over the counter and by prescription. Some common examples include aspirin, ibuprofen, indomethacin, and less commonly acetaminophen (Tylenol).
  • 3. MOA
  • 4. GENERAL CONTRAINDICATION Dont use in the: kidney problems, liver problems, stomach problems (e.g., ulcers), heart disease (e.g., arrhythmias, heart failure), high blood pressure (hypertension), diabetes, blood problems (e.g., anemia, bleeding disorders, porphyria),asthma, nasal polyps, eye problems, severe or long-lasting headaches, any allergies - especially aspirin/NSAID allergy (e.g., ibuprofen, celecoxib). This drug may make you dizzy or drowsy. Use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages
  • 5. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, use a sunscreen, and wear protective clothing when outdoors. This medicine may cause stomach bleeding. Daily use of alcohol and this medicine may increase your risk for stomach bleeding. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Using this drug during the last 6 months of pregnancy is not recommended. This drug may pass into breast milk. Consult your doctor before breast-feeding
  • 6. if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine for pain right before or after heart bypass surgery
  • 7. Aspirin contraindications peptic ulcer bleeding disorder hypersensitivity to nsaids under <12 children liver disease pregnancy and lactation chickenpox or influenza infection
  • 9. indomethacin Contraindication machinery operators Drivers Psychiatric patients Epileptics Kidney disease Pregnant women children
  • 10. ibuprofen Contraindications peptic ulcer Lactting mother Pregnancy Hypersensitivity Unknown bleeding Children under seven
  • 11. Diclofenac sodium Contraindication Peptic ulcer Children under seven years Kidney and liver disease