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Reiji okazaki

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Reiji Okazaki was a pioneering Japanese molecular biologist who discovered Okazaki fragments. Okazaki fragments allow for replication of the lagging DNA strand in short segments, since DNA polymerase can only add nucleotides in the 5' to 3' direction. This discovery explained how both strands of DNA are replicated with only one type of polymerase. Okazaki made many important contributions to understanding DNA replication before passing away, and he and his wife Tsuneko Okazaki received numerous honors for their scientific achievements.

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REIJI OKAZAKI
REIJI OKAZAKI ✿ Reiji Okazaki was a pioneer japanese molecular biologist. ✿ Discovered okazaki particles. ✿ Married to Tsuniki Okazaki, discoverer of RNA primer
OKAZAKI FRAGMENTS What are the Okazaki Fragments? Okazaki fragments allow for the replication of 3'-5' strand, known as lagging strand The 5'-3' strand, also known as the leading strand, is replication in one continuous piece These exist because DNA replication occurs in the 5'-3' direction because DNA polymerase acts on the 3'-OH of the existing strand for adding free nucleotides
OKAZAKI'S LIFE ✿ Okazaki was born on 8th october 1930, Hiroshima,Japan ✿ He also had expertise in engineering but he chose to make career in biology ✿ He married his fellow scientist Tsuneke Okazaki in 1958 ✿ His first discovery of the novel nucleotide bought him an opportunity to work under Kornberg's Laboratory in U.S.A ✿ Ms.Sakabe played an important role in the discovery of okazaki fragments
OKAZAKI'S WOODEN LABORATORY
AWARDS AND HONORS ✿ Tsuneko and Reiji Okazaki Award is given annually to an early career scientist who has made significant biological contributions in honor of the spirit and legacy of Professors Okazaki ✿ Had he been alive,he would have been awarded a Nobel Prize
IMPLICATIONS OF HIS RESEARCH ✿ Okazaki fragments form on the lagging strand of DNA during transcription,because it helps reduce strain put on the lagging strand. ✿ If they were all in one big chunk, it would make it more difficult for the transcription bubble to stay open, as the strands would keep wanting to stiffen and stick to each other. Conventionally, it was believed that there were two different enzymes, one elongating the strand from the 5' to 3' direction and another elongating the strand from the 3' to 5' direction. However, in fact, there was only one enzyme that elongates the strand from the 5' to 3' direction. So we attempted to explain how two strands were oriented in the double helix with only one enzyme.- Prof.Okazaki
REFERENCES ✿ wwww.ncbi.nlm.nih.gov/pmc/articles/pMC5489436/ ✿ https://www.revolvy.com/page/Reiji-Okazaki ✿ www.itbm.nagoya-u.ac.jp/en/public/nu_research/features/detail/003970.html ✿ http://www.itbm.nagoya-u.ac.jp/okazaki_award/ ✿ https://kundoc.com/pdf-reiji-okazaki-19301975-.html ✿ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489436/ ✿ https://www.researchgate.net/publication/22868133_Discontinuous_replication_of_ replicative_form_DNA_from_bacteriophage_phiX174

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Reiji okazaki

  • 2. REIJI OKAZAKI ✿ Reiji Okazaki was a pioneer japanese molecular biologist. ✿ Discovered okazaki particles. ✿ Married to Tsuniki Okazaki, discoverer of RNA primer
  • 3. OKAZAKI FRAGMENTS What are the Okazaki Fragments? Okazaki fragments allow for the replication of 3'-5' strand, known as lagging strand The 5'-3' strand, also known as the leading strand, is replication in one continuous piece These exist because DNA replication occurs in the 5'-3' direction because DNA polymerase acts on the 3'-OH of the existing strand for adding free nucleotides
  • 4. OKAZAKI'S LIFE ✿ Okazaki was born on 8th october 1930, Hiroshima,Japan ✿ He also had expertise in engineering but he chose to make career in biology ✿ He married his fellow scientist Tsuneke Okazaki in 1958 ✿ His first discovery of the novel nucleotide bought him an opportunity to work under Kornberg's Laboratory in U.S.A ✿ Ms.Sakabe played an important role in the discovery of okazaki fragments
  • 6. AWARDS AND HONORS ✿ Tsuneko and Reiji Okazaki Award is given annually to an early career scientist who has made significant biological contributions in honor of the spirit and legacy of Professors Okazaki ✿ Had he been alive,he would have been awarded a Nobel Prize
  • 7. IMPLICATIONS OF HIS RESEARCH ✿ Okazaki fragments form on the lagging strand of DNA during transcription,because it helps reduce strain put on the lagging strand. ✿ If they were all in one big chunk, it would make it more difficult for the transcription bubble to stay open, as the strands would keep wanting to stiffen and stick to each other. Conventionally, it was believed that there were two different enzymes, one elongating the strand from the 5' to 3' direction and another elongating the strand from the 3' to 5' direction. However, in fact, there was only one enzyme that elongates the strand from the 5' to 3' direction. So we attempted to explain how two strands were oriented in the double helix with only one enzyme.- Prof.Okazaki
  • 8. REFERENCES ✿ wwww.ncbi.nlm.nih.gov/pmc/articles/pMC5489436/ ✿ https://www.revolvy.com/page/Reiji-Okazaki ✿ www.itbm.nagoya-u.ac.jp/en/public/nu_research/features/detail/003970.html ✿ http://www.itbm.nagoya-u.ac.jp/okazaki_award/ ✿ https://kundoc.com/pdf-reiji-okazaki-19301975-.html ✿ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489436/ ✿ https://www.researchgate.net/publication/22868133_Discontinuous_replication_of_ replicative_form_DNA_from_bacteriophage_phiX174