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TAHITIAN NONI® Juice Human Clinical Research

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Morinda IPC
Morinda IPC

This document summarizes several human clinical studies that evaluated the effects of consuming Tahitian Noni Juice (TNJ). The studies found that drinking 2 ounces of TNJ twice daily for 1-3 months showed: 1) A reduction in free radicals and DNA damage in heavy smokers. 2) Positive effects on blood lipid profiles in heavy smokers such as decreased total cholesterol and LDL, and increased HDL. 3) Improvement in quality of life scores and reduced fatigue in post-menopausal women. 4) Reduced blood pressure in hypertensive subjects. 5) Reduced joint pain and increased mobility in subjects with cervical spondylosis.

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TAHITIAN NONI® Juice Human Clinical Research © 2008 TAHITIAN NONI INTERNATIONAL
TAHITIAN NONI Juice delivers superior antioxidants that help rid the body of harmful free radicals 1. Free radicals in the blood—double-blind human clinical trial 2 fl. oz. TNJ or placebo BID for 1 month 38 smokers assigned to TNJ 30 smokers assigned to placebo Placebo (grape & blueberry juice)—no significant effect TAHITIAN NONI® Juice—statistically significant reduction in free radicals in the blood 27% reduction in SAR 23% reduction in LPO © 2008 TAHITIAN NONI INTERNATIONAL
2. MDA-DNA adduct—in lymphocytes of heavy smokers 1 or 4 fl. oz. TNJ BID for 1 month Placebo— 305.27% increase (n=42, P<0.001) TAHITIAN NONI® Juice— 53.36% reduction (n=203, p<0.001) 3. Aromatic-DNA adduct—in lymphocytes of heavy smokers 1 or 4 fl. oz. TNJ BID for 1 month Placebo— 4.99% increase (n=42, P>0.05) TAHITIAN NONI® Juice— 44.9% reduction (n=203, p<0.0001) © 2008 TAHITIAN NONI INTERNATIONAL
TAHITIAN NONI Juice helps maintain cholesterol at existing healthy levels Lipid Profiles in heavy smokers  38 Current Smokers drank 2 ounces of TAHITIAN NONI® Juice twice a day for 30 days.  30 Current Smokers drank 2 ounces of a placebo.  TNJ had a positive effect on blood lipid profiles.  Placebo had no positive effect © 2008 TAHITIAN NONI INTERNATIONAL
Trial Results Decreased Increased Total cholesterol: 7–22% LDL: 6-10% Triglyceride: 10-54% Homocysteine: 21% HDL: 10-16% © 2008 TAHITIAN NONI INTERNATIONAL
Type B Lipoprotein Profile BAD Type A Lipoprotein Profile GOOD © 2008 TAHITIAN NONI INTERNATIONAL
Placebo Before After: No change © 2008 TAHITIAN NONI INTERNATIONAL
TAHITIAN NONI® Juice Before After © 2008 TAHITIAN NONI INTERNATIONAL
TAHITIAN NONI Juice increases energy © 2008 TAHITIAN NONI INTERNATIONAL
Pilot Clinical Study in Post- menopausal Women University of Illinois College of Medicine Drank 2 fl oz TNJ both morning and night for 3 months Assessed with SF-36 clinical survey. Results: Overall improvement in quality of life, including physical function scores and significant improvement in mood and well being © 2008 TAHITIAN NONI INTERNATIONAL
Improvement in Physical Functioning Scores © 2008 TAHITIAN NONI INTERNATIONAL
The QLQ-C30 used in the University of Hawaii Study SCALE NO YES 1. Do you have any trouble doing Physical 1 2 strenuous activities, like carrying a heavy shopping bag or a suitcase? 2. Do you have any trouble taking a long Physical 1 2 walk? 3. Do you have any trouble take a short Physical 1 2 walk outside of the house? 4. Do have to stay in bed or a chair for Physical 1 2 most of the day? 5. Do you need help with eating, Physical 1 2 dressing, washing yourself or using the toilet? Quit Very Not A During the past week: SCALE e a muc at all little bit h 10. Did you need rest? Fatigue 1 2 3 4 12. Have you felt weak? Fatigue 1 2 3 4 © 2008 TAHITIAN NONI INTERNATIONAL
TAHITIAN NONI Juice supports a healthy cardiovascular system and helps maintain a healthy heart Human Clinical Project at BYU-Hawaii 2006  10 Medically-diagnosed hypertensive subjects  Drink 2 ounces of TNJ twice a day for 30 days  Lowers High Blood Pressure • Pre-treatment Average = 144/83 • Post-treatment Average = 132/76 © 2008 TAHITIAN NONI INTERNATIONAL
TAHITIAN NONI Juice supports joint health TAHITIAN NONI® Juice in Patients with Cervical Spondylosis  University of Lagos College of Medicine  90 subjects (TNJ alone, TNJ+physical therapy, physical therapy alone)  15 mL TNJ Juice BID for 4 weeks  No NSAIDS or analgesics allowed  Pre and post pain and cervical range of movement (ROM) measured © 2008 TAHITIAN NONI INTERNATIONAL
© 2008 TAHITIAN NONI INTERNATIONAL
Results Pain intensity decreased significantly from moderate-severe range to none-moderate range in all three groups When TNJ combined with physical therapy, cervical pain eliminated in almost all subjects. © 2008 TAHITIAN NONI INTERNATIONAL
Extension Flexion Rotation Lateral Flexion © 2008 TAHITIAN NONI INTERNATIONAL
Range of Movement Degrees of TNJ TNJ+PT PT movement (Before-After) (Before-After) (Before-After) Flexion 19.9 36.7 20.4 46.9 20.7 40.1 Extension 20.1 36.6 18.8 47.7 19.1 41.5 Lateral 18.0 35.0 17.7 42.5 17.9 38.1 Flexion Rotation 19.4 40.6 20.0 50.5 20.2 42.5 © 2008 TAHITIAN NONI INTERNATIONAL

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TAHITIAN NONI® Juice Human Clinical Research

  • 1. TAHITIAN NONI® Juice Human Clinical Research © 2008 TAHITIAN NONI INTERNATIONAL
  • 2. TAHITIAN NONI Juice delivers superior antioxidants that help rid the body of harmful free radicals 1. Free radicals in the blood—double-blind human clinical trial 2 fl. oz. TNJ or placebo BID for 1 month 38 smokers assigned to TNJ 30 smokers assigned to placebo Placebo (grape & blueberry juice)—no significant effect TAHITIAN NONI® Juice—statistically significant reduction in free radicals in the blood 27% reduction in SAR 23% reduction in LPO © 2008 TAHITIAN NONI INTERNATIONAL
  • 3. 2. MDA-DNA adduct—in lymphocytes of heavy smokers 1 or 4 fl. oz. TNJ BID for 1 month Placebo— 305.27% increase (n=42, P<0.001) TAHITIAN NONI® Juice— 53.36% reduction (n=203, p<0.001) 3. Aromatic-DNA adduct—in lymphocytes of heavy smokers 1 or 4 fl. oz. TNJ BID for 1 month Placebo— 4.99% increase (n=42, P>0.05) TAHITIAN NONI® Juice— 44.9% reduction (n=203, p<0.0001) © 2008 TAHITIAN NONI INTERNATIONAL
  • 4. TAHITIAN NONI Juice helps maintain cholesterol at existing healthy levels Lipid Profiles in heavy smokers  38 Current Smokers drank 2 ounces of TAHITIAN NONI® Juice twice a day for 30 days.  30 Current Smokers drank 2 ounces of a placebo.  TNJ had a positive effect on blood lipid profiles.  Placebo had no positive effect © 2008 TAHITIAN NONI INTERNATIONAL
  • 5. Trial Results Decreased Increased Total cholesterol: 7–22% LDL: 6-10% Triglyceride: 10-54% Homocysteine: 21% HDL: 10-16% © 2008 TAHITIAN NONI INTERNATIONAL
  • 6. Type B Lipoprotein Profile BAD Type A Lipoprotein Profile GOOD © 2008 TAHITIAN NONI INTERNATIONAL
  • 7. Placebo Before After: No change © 2008 TAHITIAN NONI INTERNATIONAL
  • 8. TAHITIAN NONI® Juice Before After © 2008 TAHITIAN NONI INTERNATIONAL
  • 9. TAHITIAN NONI Juice increases energy © 2008 TAHITIAN NONI INTERNATIONAL
  • 10. Pilot Clinical Study in Post- menopausal Women University of Illinois College of Medicine Drank 2 fl oz TNJ both morning and night for 3 months Assessed with SF-36 clinical survey. Results: Overall improvement in quality of life, including physical function scores and significant improvement in mood and well being © 2008 TAHITIAN NONI INTERNATIONAL
  • 11. Improvement in Physical Functioning Scores © 2008 TAHITIAN NONI INTERNATIONAL
  • 12. The QLQ-C30 used in the University of Hawaii Study SCALE NO YES 1. Do you have any trouble doing Physical 1 2 strenuous activities, like carrying a heavy shopping bag or a suitcase? 2. Do you have any trouble taking a long Physical 1 2 walk? 3. Do you have any trouble take a short Physical 1 2 walk outside of the house? 4. Do have to stay in bed or a chair for Physical 1 2 most of the day? 5. Do you need help with eating, Physical 1 2 dressing, washing yourself or using the toilet? Quit Very Not A During the past week: SCALE e a muc at all little bit h 10. Did you need rest? Fatigue 1 2 3 4 12. Have you felt weak? Fatigue 1 2 3 4 © 2008 TAHITIAN NONI INTERNATIONAL
  • 13. TAHITIAN NONI Juice supports a healthy cardiovascular system and helps maintain a healthy heart Human Clinical Project at BYU-Hawaii 2006  10 Medically-diagnosed hypertensive subjects  Drink 2 ounces of TNJ twice a day for 30 days  Lowers High Blood Pressure • Pre-treatment Average = 144/83 • Post-treatment Average = 132/76 © 2008 TAHITIAN NONI INTERNATIONAL
  • 14. TAHITIAN NONI Juice supports joint health TAHITIAN NONI® Juice in Patients with Cervical Spondylosis  University of Lagos College of Medicine  90 subjects (TNJ alone, TNJ+physical therapy, physical therapy alone)  15 mL TNJ Juice BID for 4 weeks  No NSAIDS or analgesics allowed  Pre and post pain and cervical range of movement (ROM) measured © 2008 TAHITIAN NONI INTERNATIONAL
  • 15. © 2008 TAHITIAN NONI INTERNATIONAL
  • 16. Results Pain intensity decreased significantly from moderate-severe range to none-moderate range in all three groups When TNJ combined with physical therapy, cervical pain eliminated in almost all subjects. © 2008 TAHITIAN NONI INTERNATIONAL
  • 17. Extension Flexion Rotation Lateral Flexion © 2008 TAHITIAN NONI INTERNATIONAL
  • 18. Range of Movement Degrees of TNJ TNJ+PT PT movement (Before-After) (Before-After) (Before-After) Flexion 19.9 36.7 20.4 46.9 20.7 40.1 Extension 20.1 36.6 18.8 47.7 19.1 41.5 Lateral 18.0 35.0 17.7 42.5 17.9 38.1 Flexion Rotation 19.4 40.6 20.0 50.5 20.2 42.5 © 2008 TAHITIAN NONI INTERNATIONAL