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Protection of humans during long space flight. using cannabis to reduce biological consequences of high doses of radiation, treat stress, anxiety, and depression Associated with Long-term Space Flight to Mars. Antiradiation antidote
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The document discusses an anti-radiation antidote developed using antibodies against the membrane attack complex (MAC). MAC is activated after irradiation and plays a toxic role in acute radiation syndromes. Rabbits were inoculated with "specific radiation determinants" from irradiated animals to produce hyper-immune serum with high levels of IgG antibodies against MAC. Animals treated with these antibodies before and after lethal irradiation showed 60-75% survival rates and reduced radiation sickness symptoms compared to untreated controls where all animals died. The results suggest targeting MAC with specific antibodies may provide significant but incomplete protection against high radiation doses.Marihuana acute intoxication: express diagnosis with ELISA
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This document discusses using an ELISA test to detect acute marijuana intoxication. It describes how ELISA tests work to detect THC metabolites in urine or saliva, which can confirm a diagnosis of acute marijuana intoxication. ELISA tests have detection limits of 20-100 ng/mL in urine and can detect THC and its metabolites for several hours after marijuana use. The document also provides background information on the pharmacokinetics of THC and discusses symptoms of acute marijuana intoxication.
Polyclonal/ monoclonal antibodies to serotonin receptors as a therapeutic age...
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Polyclonal/monoclonal antibodies to serotonin receptors have potential as therapeutic agents. Serotonin receptors mediate effects of serotonin and are targets of many drugs. Antibodies to specific serotonin receptors could modulate receptor signaling and impact conditions like depression, anxiety, nausea, and pain. Developing therapeutic antibodies requires overcoming challenges but may help treat diseases influenced by the serotonin system.Comprehensive toxicology: Ionized Radiation as Carcinogen.
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Polyclonal/monoclonal antibodies to histamine receptors have potential as selective antihistamine agents. They may block the inflammatory and immune effects of histamine by targeting its four receptor types: H1, H2, H3, and H4. Developing monoclonal antibodies as antagonists/agonists of these receptors could provide effective therapies for conditions like allergies, asthma, gastrointestinal issues, and cognitive disorders. Several companies produce antibodies to the different histamine receptors for research applications.ANTIOXIDANTS AND POTASSIUM FERROCYANIDE, A PROPHYLACTIC AND THERAPEUTIC MIXTU...
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This document discusses research on developing an anti-radiation T cell vaccine. It describes T cells and their role in cell-mediated immunity, including recognizing radiation antigens created by radiation damage. The proposed anti-radiation T cell vaccine would generate immunological memory to radiation antigens, protecting against future radiation exposure through memory T cells that can quickly respond. It would work by modulating cytotoxic T cells to induce apoptosis in cells displaying radiation epitopes, without causing necrosis.Implications for Immunotherapy of Acute Radiation Syndromes. Part 2.
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Research Proposal:ÌýImplications for Immunotherapy of Acute Radiation Syndromes. Part 2.
Dmitri Popov
Full-text available · Research Proposal · Feb 2017
File name:ÌýImplications for Immunotherapy of ARS. Part 2.
Implications for Immunotherapy of Acute Radiation Syndromes.
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This document discusses the effects of radiation on immune systems and antigenic properties of tissues. It provides background on how radiation can induce cell death and damage, triggering immune responses. Studies discussed show that radiation can change the antigenic composition and properties of tissues, making them more immunogenic. Radiation is found to increase antigen processing in tumor cells and increase their susceptibility to immune cell killing. The document examines how radiation affects the antigenic properties of both normal and tumor tissues.Radiation Toxicology: Glycoproteins. 
Radiation Toxicology: Glycoproteins. Dmitri Popov
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1. Glycoproteins play an important role in inflammatory and pathological processes after radiation exposure. Quantifying circulating glycoprotein levels using ELISA can help with the differential diagnosis of acute radiation syndromes.
2. Changes in the glycan structures of acute phase glycoproteins are dynamically altered in response to inflammation. Measuring these changes can improve diagnosis, prognosis, and risk prediction of inflammatory disorders after radiation exposure.
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Redbook 2000: General Guidelines for Designing and Conducting Toxicity Studies.Dmitri Popov
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This document provides guidelines for designing and conducting toxicity studies, including recommendations for animal care, selection of species/strains, clinical testing procedures, urinalysis, neurotoxicity and immunotoxicity screening, and microscopic evaluation of tissues. It recommends following NIH and DHEW guidelines for animal care and housing. Both male and female rodents (usually rats) and non-rodents (usually dogs) should be used. Ophthalmological exams, hematology, clinical chemistry, and urinalysis should be conducted according to schedules in other FDA guidelines. Tissues should be examined microscopically for abnormalities.Guidance for Industry and Other Stakeholders Toxicological Principles for the...
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Radiation protection: desensitization to radiation.Dmitri Popov
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This document discusses radiation allergen immunotherapy, also known as desensitization or hypo-sensitization, as a treatment for acute radiation syndromes. It involves exposing patients to increasing amounts of radiation allergen in an attempt to change the immune system's response to high radiation doses. Specifically, it aims to induce tolerance to radiation by reducing IgE production and shifting the immune response away from humoral immunity toward cellular immunity. The objective is to develop tolerance to radiation in patients by altering radiation allergens through extensive irradiation or changes to specific amino acids.Radiation Protection : Phospholipase A
Radiation Protection : Phospholipase ADmitri Popov
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The document discusses research on using phospholipase A2 (PLA2) antibodies to protect cells from radiation damage. PLA2 is an enzyme that releases fatty acids from phospholipids in cell membranes. Exposure to ionizing radiation activates PLA2, leading to cell death. The research proposal is to test whether antibodies that block PLA2 can inhibit this activation and thereby reduce the toxic effects of radiation exposure and increase radiation survival. Blocking PLA2 with antibodies may provide a new radiation protection strategy and tool for diagnosing and monitoring acute radiation sickness.Radiation protection: Sphingolipids
Radiation protection: SphingolipidsDmitri Popov
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Radiation Protection: Sphingolipids.
The document discusses sphingolipids and their potential role in radiation protection. Sphingolipids are a class of lipids found in cell membranes that are involved in cell signaling and recognition. Exposure to radiation can damage sphingolipids in cell membranes. Inhibition of sphingomyelinase, an enzyme involved in sphingolipid metabolism, may protect against radiation-induced cell damage by preventing the production of ceramide, a sphingolipid metabolite involved in apoptosis. Further research is proposed to study the effects of radiation on sphingolipid composition in tissues and whether this protection sphingolipid-rich membranes against radiation damage.More Related Content
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Polyclonal/monoclonal antibodies to histamine receptors have potential as selective antihistamine agents. They may block the inflammatory and immune effects of histamine by targeting its four receptor types: H1, H2, H3, and H4. Developing monoclonal antibodies as antagonists/agonists of these receptors could provide effective therapies for conditions like allergies, asthma, gastrointestinal issues, and cognitive disorders. Several companies produce antibodies to the different histamine receptors for research applications.ANTIOXIDANTS AND POTASSIUM FERROCYANIDE, A PROPHYLACTIC AND THERAPEUTIC MIXTU...
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This document discusses research on developing an anti-radiation T cell vaccine. It describes T cells and their role in cell-mediated immunity, including recognizing radiation antigens created by radiation damage. The proposed anti-radiation T cell vaccine would generate immunological memory to radiation antigens, protecting against future radiation exposure through memory T cells that can quickly respond. It would work by modulating cytotoxic T cells to induce apoptosis in cells displaying radiation epitopes, without causing necrosis.Implications for Immunotherapy of Acute Radiation Syndromes. Part 2.
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Research Proposal:ÌýImplications for Immunotherapy of Acute Radiation Syndromes. Part 2.
Dmitri Popov
Full-text available · Research Proposal · Feb 2017
File name:ÌýImplications for Immunotherapy of ARS. Part 2.
Implications for Immunotherapy of Acute Radiation Syndromes.
Implications for Immunotherapy of Acute Radiation Syndromes.Dmitri Popov
Ìý
This document discusses the effects of radiation on immune systems and antigenic properties of tissues. It provides background on how radiation can induce cell death and damage, triggering immune responses. Studies discussed show that radiation can change the antigenic composition and properties of tissues, making them more immunogenic. Radiation is found to increase antigen processing in tumor cells and increase their susceptibility to immune cell killing. The document examines how radiation affects the antigenic properties of both normal and tumor tissues.Radiation Toxicology: Glycoproteins.
Radiation Toxicology: Glycoproteins. Dmitri Popov
Ìý
1. Glycoproteins play an important role in inflammatory and pathological processes after radiation exposure. Quantifying circulating glycoprotein levels using ELISA can help with the differential diagnosis of acute radiation syndromes.
2. Changes in the glycan structures of acute phase glycoproteins are dynamically altered in response to inflammation. Measuring these changes can improve diagnosis, prognosis, and risk prediction of inflammatory disorders after radiation exposure.
3. Glycoproteins are proteins that contain oligosaccharide chains and play key roles in processes like cell recognition and the immune response through molecules like antibodies, MHC proteins, and Sialyl Lewis X antigen.Radiation Protection: Radiation Toxicology: neuraminidase enzymes, neuraminid...
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Radiation can alter protein glycosylation patterns. Neuraminidase enzymes cleave sialic acids from glycoproteins and glycolipids. Viral and bacterial neuraminidases play roles in infection, while mammalian neuraminidases have various functions. Radiation combined with immunotherapy using neuraminidase-treated tumor cells shows improved tumor regression compared to either treatment alone in mouse models of cancer.Redbook 2000: IV.B.3 Pathology Considerations in Toxicity Studies Toxicologic...
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Redbook 2000: General Guidelines for Designing and Conducting Toxicity Studies.Dmitri Popov
Ìý
This document provides guidelines for designing and conducting toxicity studies, including recommendations for animal care, selection of species/strains, clinical testing procedures, urinalysis, neurotoxicity and immunotoxicity screening, and microscopic evaluation of tissues. It recommends following NIH and DHEW guidelines for animal care and housing. Both male and female rodents (usually rats) and non-rodents (usually dogs) should be used. Ophthalmological exams, hematology, clinical chemistry, and urinalysis should be conducted according to schedules in other FDA guidelines. Tissues should be examined microscopically for abnormalities.Guidance for Industry and Other Stakeholders Toxicological Principles for the...
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This guidance represents the Food and Drug Administration's (FDA's) current thinking on this topic. It
does not create or confer any rights for or on any person and does not operate to bind FDA or the public.Radiation protection: desensitization to radiation.
Radiation protection: desensitization to radiation.Dmitri Popov
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This document discusses radiation allergen immunotherapy, also known as desensitization or hypo-sensitization, as a treatment for acute radiation syndromes. It involves exposing patients to increasing amounts of radiation allergen in an attempt to change the immune system's response to high radiation doses. Specifically, it aims to induce tolerance to radiation by reducing IgE production and shifting the immune response away from humoral immunity toward cellular immunity. The objective is to develop tolerance to radiation in patients by altering radiation allergens through extensive irradiation or changes to specific amino acids.Radiation Protection : Phospholipase A
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The document discusses research on using phospholipase A2 (PLA2) antibodies to protect cells from radiation damage. PLA2 is an enzyme that releases fatty acids from phospholipids in cell membranes. Exposure to ionizing radiation activates PLA2, leading to cell death. The research proposal is to test whether antibodies that block PLA2 can inhibit this activation and thereby reduce the toxic effects of radiation exposure and increase radiation survival. Blocking PLA2 with antibodies may provide a new radiation protection strategy and tool for diagnosing and monitoring acute radiation sickness.Radiation protection: Sphingolipids
Radiation protection: SphingolipidsDmitri Popov
Ìý
Radiation Protection: Sphingolipids.
The document discusses sphingolipids and their potential role in radiation protection. Sphingolipids are a class of lipids found in cell membranes that are involved in cell signaling and recognition. Exposure to radiation can damage sphingolipids in cell membranes. Inhibition of sphingomyelinase, an enzyme involved in sphingolipid metabolism, may protect against radiation-induced cell damage by preventing the production of ceramide, a sphingolipid metabolite involved in apoptosis. Further research is proposed to study the effects of radiation on sphingolipid composition in tissues and whether this protection sphingolipid-rich membranes against radiation damage.