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imaging in brain drug targeting intra-cerebro-ventricular infusion blood brain barrier disruption transporter-mediated delivery blood-tumor barrier blood-cerebrospinal fluid barrier blood-brain barrier pharmacodynamic drug-drug interactions excretion interactions metabolism interactions distribution interactions absorption interactions pharmacokinetic drug-drug interactions pharmaceutic behavioural drug-drug interactions product age & storage conditions pharmaceutical ingredients in vitro correlation of drug absorption tablets capsules suspensions solutions nature & type of dosage form compression force method of granulation manufacturing variables disintegration time adsorption complexation drug stability and hydrolysis in git crystal form salts dissolution and ph lipid solubility of drugs ph - partition theory age effect of food and nutrients splanchnic blood flow intestinal transit drug stability in git intestinal motility gastric emptying rate gastero-intestinal physiology ion pair formation pore transport vesicular transport carrier mediated transport passive diffusion transport processes nature of cell membrane enteral routes parentral single dose vaccine delivery systems oral polio vaccine oral immunization knowledge of peptide based and nucleic acid based delivery systems used to promote uptake evidence and mechanism of uptake and transport of types of vaccines immunization cells of immune system evaluation of transdermal therapeutic systems preparation of different types of transdermal patc design of transdermal patches combinatorial enhancement techniques chemical enhancers physical techniques transdermal absorption enhancers factors affecting transdermal permeability mechanism of drug permeation skin permeation pathways skin barrier problems associated with mab’s applications of mab evaluation of mab in vivo methods in vitro methods propagation of mab steps involved in production of mab by hybridoma t types of monoclonal antibodies (mab) classification of antibodies evaluation of predictability of ivivc procedure for in-vitro in-vivo correlation biopharmaceutics classification system (bcs) level d correlation multiple-level c correlation level c correlation level b correlation level a correlation pharmacokinetic parameters in-vivo studies formation of impurities on aging impurities related to formulation impurities assossiated in with apis transformation products related products penultimate intermediate intermediates interaction products degradation products by products types of impurities parenteral products aerosols solid dosage forms vapor pressure osmometry & equilibrium dialysis hplc and fluorescent measurement tlc and hptlc self interactive chromatography diffuse reflectance spectroscopy accelareted stability study differential thermal analysis(dta) dsc- differential scanning calorimetry method of analysis storage sample preparation compatibility tests factors affecting circadian rhythms auto inhibition auto-induction csf drug concentration renal clearance systemic clearance enzymatic metabolic activity distribution and plasma binding absorption-elimination parameters time dependency infradian rhythms ultradian rhythms circadian rhythms types of body rhythms chronopharmacokinetic studies respiratory stimulants antihistamines nonopioids opioids antitussives mucolytics bronchial secretion enhancers expectorants anti-ige antibody corticosteroids mast cell stabilizers leukotriene antagonists bronchodilators anti asthmatic drugs henderson - hasselbach equation concentration gradient noyes and whitney equation usp dministration pharmacodynamic excipients ph-partition solubility product bioavailability biopharamaceutics