Resident Evil 6 is a survival horror game featuring three interwoven storylines across North America, Eastern Europe, and China. Players can choose from characters like Leon S. Kennedy, Chris Redfield, and Jake Muller, with new mutations of the C-virus posing evolving threats. The game introduces co-op gameplay and a "Crossover" mechanic allowing up to four players to experience key moments online. It also includes new enemy types, character upgrades, vehicle sections, and the return of the Mercenaries mode.