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functions of cells melanocytes merkel cells oral hygiene inflamatory cells langerhans cells non keratinocytes rheumatoid arthritis prostratitis renal transplant pancreatic malignancy alzhiemers translational periodontitis diabetes cardiovascular diseases focus of infection reduced patient discomfirt autogenous graft human periosteum mucogingival surgical procedures millers classification root coverage procedures novel technique oxidative bursts periodontics regulators cells scafolds growth factors tissue engineering treatment pathogenesis microbiology diseased root cementum root cell structure inflammatory cells langerhans cell connective tissue epithelium enzymatic destruction chemotaxis neutrophils aids patients hiv patients periodontitis prevalance phagocytosis