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cost barcelona 2013 ngs cost data analysis metabolomics data integration rna johan westerhuis michael lappe x-omics endre barta chipseq rna-seq mikael huss analysis proteomics ignasi forne i ferrer immune system mirna esteban ballestar medall josep maria anto marta benet biology david gomez-cabrero ioannis tsamardinos sofia triantafillou hilmar ilgenfritz omics knowledge management