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human genome ngs reference standards dna crispr sgrna raav personalised medicines personalizing medicine cancer cancer therapies crispr-cas9 target validation drug discovery genome editing tools genome molecular diagnostics clinical laboratory ffpe ihc gene editing translating genomes raav and zfns diagnostics hek293 adenoviral grna oligo cas9 zinc fingers ²µ±ð²Ô±ð²õ¾±²õâ„¢ genomic theranostics sanger sequencing single-nucleotide variants next-generation sequencing multiplex genome in a bottle gene-editing exome bioinformatics combination drugs synergies next generation sequencing standards references iso 13485 fda strategy iso 9001 quality management system rna-based screening x-manâ„¢ isogenic cell lines chts sirna antagonism her2 biomarkers quantitative standards eqa wrt gene restriction digest analysis shrna knock out screening sirnas rnai cancer cell lines drug target suitability gene ²µ³Ü¾±»å±ð²ú´Ç´Ç°ìâ„¢ dna assays genetic alterations ³¦°ù¾±²õ±è°ù┶ij¦²¹²õ9 essentiality tumour pcr formalin-fixed paraffin-embedded (ffpe) tissues fish egfr genetics drugs patients therapeutic strategies clone cfdna nsclc cancer biopsies dna extraction western blot immunohistochemistry assay failure standardization assay controls quantitative digital pathology cell lines nist knockout (gecko) screening mdm2 inhibitor combination immuno-oncology guiderna talens rna crispr/cas9 gene targeting techniques xenografts tumor microenvironment knock-out cell line synthetic lethality mutation formalin tumor validate software optimisation molecular assays