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Greater Pittsburgh Area United States

Professor

Education

My laboratory investigates the regulation of neuronal autophagy, kinase signaling pathways, and mitochondrial quality control, particularly as applied to Parkinson’s disease. One of our early discoveries was of altered trafficking of kinases and transcription factors in neurons subjected to oxidative stress; specifically, decreased nuclear localization and transcriptional function, and increased mitochondrial activity. Similar alterations are observed in human Parkinson’s disease brains in association with mitochondria undergoing autophagy. We study the regulation of neuronal autophagy and mitochondrial quality control with respect to proteins that contribute to familial Parkinson...