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assignment ethical guidelines for biomedical research and hum icmr mechanism of mutation genotoxicity studies ames test in vitro micronucleus in vivo micronucleus in vitro chromosomal aberrations studies in vivo chromosomal aberrations studies reproductive toxicology studies male reproductive toxicity studies female reproductive studies (segment i and segment teratogenecity studies (segment ii) experimental study- rct and non rct observation study: cohort case control cross sectional roles and responsibilities of clinical trial perso study coordinator sponsor contract research organization and its management preparation of protocol investigator brochure case report forms clinical study report clinical trial monitoring-sa history and progress of pharmacovigilance significance of safety monitoring pharmacovigilance in india and international aspec who international drug monitoring programme who and regulatory terminologies of adr evaluation of medication safety establishing pharmacovigilance centres in hospital industry and national programmes related to pharma roles and responsibilities in pharmacovigilance international non-proprietary names for drugs international classification of diseases passive and active surveillance comparative observational studies targeted clinical investigations and vaccine safet aris g pharmacovigilance vigiflow statistical methods for evaluating medication safe basic definition and types of toxicology (general mechanistic regulatory and descriptive) regulatory guidelines for conducting toxicity stud ich epa and schedule y oecd principles of good laborat origin and principles of international conference (ich-gcp) guidelines ethical committee- institutio no and diacylglycerol. detailed study of following in mitogen-activated protein kinase (mapk) signaling janus kinase (jak)/signal transducer and activator assignment on general principles of immunoassay: t heterogeneous and homogenous immunoassay systems. protocol outline objectives and preparation. immunoassay for digoxi assignment on recombinant dna technology and gene various types of vectors applications of recombinant dna technology. gene t clinical applications and recent advances in gene assignment on alternatives to animal screening met assignment on limitation of animal experimentation preclinical screening of new substances for the ph in vitro and other possible animal alternative models assignment on preclinical and clinical screening o in vitro anticancer agent anti vivo anti cancer gene mapping and cloning of disease gene genetic variation and its role in health pharmacol polymorphism affecting drug metabolism importance of si rna and microrna gene sequencing methods toxicokinetics- toxicokinetic evaluation in precli saturation kinetics importance and applications of need of cell signaling steps in cell signaling intercellular signaling pathways types of intercellular signaling pathways intracellular signaling pathways receptors intercellular and intracellular signaling pathways gprotein coupled receptors tyrosine kinase receptors and nuclear receptors. immunotherapy types of immunotherapeutics humanisation antibody therapy immunotherapeutics in clinical practice cell cycles and its regulation. cell death鈥� events regulators intrinsic and extrinsic pathways of apoptosis. nec secondary messengers: cyclic amp cyclic gmp calcium ion inositol 1 4 5- trisphosphate (ip3) genome organisation