The document summarizes the methodology and results of 27 studies that examined priming in Alzheimer's patients and controls using various experimental designs. The studies varied in the number of subjects, age and severity of impairment, number and frequency of word stimuli, exposure duration, orienting tasks, time limits, and delay between study and test phases. The results showed that Alzheimer's patients demonstrated impaired priming compared to controls on oral and written stem-completion tasks, except for some studies that found intact priming effects in mild Alzheimer's patients or when tasks involved generating meanings of words.
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REVIEW TABLE
1. REVIEW TABLE
Study Subjects Methodology Results
number
of
ADP*
age
of
ADP
age
of
CS*
severity
of
AD
number
of
stimuli
frequency
of
stimuli
exposure-
number
of stimuli
orienting task time-limit
(study-
phase)
time-limit
(test-
phase)
time
of
delay*
completion
of
stems
priming
Shimamura et al
(1987)
8 72 69.6 mld* to
mod*
2 ls* of
10 ws*
_ 1 rating likeability _ _ _ oral impaired
Salmon et al
(1988)
13 71.2 66.6 mld to
mod
2 ls of
10 ws
_ 2 rating likeability _ _ _ oral impaired
Heindel et al
(1989)
16 74.3 71.3 --- 2 ls of
10 ws
_ 2 rating likeability _ _ _ oral impaired
Randolph
(1991)
10 75.2 77.7 --- 10 ws _ 3 rating likeability _ _ _ written impaired
Bondi & Kaszniak
(1991)
12 70.67 69.56 --- 30 ws _ 1 rating likeability _ _ _ written impaired
Keane & Gabrieli
(1991)
10 70.5 68.2 mld to
sev*
2 ls of
10 ws
low-fre*
high fre
1 for ls 1
3 for ls 2
rating likeability _ 4 secs _ oral impaired
Bondi & Kaszniak
(1993)
12 70.67 69.56 --- 30 ws _ 1 rating likeability _ _ _ written impaired
Burke et al
(1994)
20 79.40 78.05 --- 2 ls of
10 ws
_ 2 1.rating likeability
2.producing definitons
_ _ _ written impaired
Gabrieli et al
(1994)
15 68.3 63.1 mld to
sev
6 ls of
20 ws
_ 1 1.letter condition
2.semantic condition
3.intentional condition
_ _ _ oral impaired
Carlesimo et al
(1995)
11 63.8 66.5 --- 20 ws _ 1 rating likeability _ 5 secs _ written impaired
Fleischman & Gabrieli
(1999)
91 75.6 YCS*:
21.8
OCS*:
75.8
very mld
to
mod
3 ls of
30 ws
_ 1 1.reading
2.reading and rating
3.generating from
definitions
_ 30 secs _ oral impaired
(intact for
very mild
AD)
Grosse et al
(1990)
12 72.3 73 --- 8 bl* of
10 s-f*
_ 1 sentence-frame
comletion
_ _ _ written intact
Partridge et al
(1990)
15 82.57 83.06 mld to
sev
10 ws high-fre 2 providing meaning _ _ _ oral intact
Scott et al
(1991)
14 78.64 77.36 --- 2 ls of
12 ws
_ 1 1.giving a meaningfully
related word
2.pronouncing a letter
within the word
5 secs _ 15 secs written intact
2. Russo & Spinler
(1994)
12 71.8 72.3 --- 2 ls of
10 ws
_ 2 1.rating likeability
2.providing meaning
5 secs 5 secs 10 mins oral intact
Deweer et al
(1994)
OP*:17
IN*:13
OP:73.6
IN:80.2
73.4 --- 10 ws _ 3 rating likeability _ _ _ oral intact
Huberman & Moscovitch
(1994)
7 74.4 67.5 --- 16 ws _ 1 reading and attending 3 secs _ _ oral nearly intact
(under conditions)
Fleischman et al
(1997)
28 72.8 71.5 mod 16 ws _ 1 1.reading aloud
2.generating by
meaning
30 secs _ _ oral intact
(greater for the
reading condition)
Park et al
(1998)
16 70.8 71.8 --- 8 items _ 1 1.reading aloud
2.picture-naming
_ _ _ oral intact
Koivisto et al
(1998)
14 69.3 68.2 --- 42 ws _ 1 reading aloud 4 secs _ _ oral intact
Landrum & Radtke
(1990)
14 mld:74
mod:85.1
73.4 mild
to
mod
2 ls of
20 ws
1.low-fre
2.high-fre
1 studying and answering
questions
5 secs 30 secs _ oral intact for mild ADP
impaired for mod ADP
Christensen et al
(1992)
44 mld:69.81
mod:70.54
sev:68.8
69.72 1.mild
2.mod
3.sev
10 ws _ 1 making sentences _ _ _ oral intact for mild ADP
impaired for mod to
sev ADP
Perani et al
(1992)
18 64.72 47.5 mild
to mod
5 ls of
10 ws
_ 1 learning each word
auditorily prsented
2 secs _ 20 secs oral intact for half ADP
Randolph et al
(1995)
21 65.3 65.3 --- 2 ls of
10 ws
_ 1 for ls 1
4 for ls 2
rating likeability _ _ _ oral impaired for one exs*
intact for four exs
Downes et al
(1996)
7 67.56 66.12 mld
to
mod
2 ls of
10 ws
2 ls of
40 ws
_ 1 exp*1:rating likeability
exp2:1.reading aloud
2.rating
likeability
exp1:
5 secs
exp2:
a) -
b)4 secs
exp1: -
exp2:
10 secs
exp1:
short
interval
exp2:
2 mins
oral exp1:impaired
exp2:intact for task 1
impaired for task 2
Abbreviations
ADP*: Alzheimer's patients mld*: mild bl*: block --- : no information available Note: The term "time of delay*"
CS*: controls mod*: moderate s-f*: sentence-frame indicates the interval between study
AD*: Alzheimer's disease sev*: severe exs*: exposure and test-phase of stem-completion
OP*: outpatients ls*: list exp*: experiment
IN*: institutionilised patients ws*: words fre*:frequency