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periodontics pg seminar chronic periodontitis plaque seminar antimicrobial agent surgery alveolar bone disease health periodontium wnt signalling microbiology hypersensitivity reaction immunity basic osteoblast immunology classification world workshop 2017 hemostasis gingiva blood collagen arrangement collagen gingival connective tissue radiological evaluation clinical evaluation implant dental recession coverage plastic surgery prf platelet rationale instruments microsurgery antiplaque postgraduate local systemic periodontitis periodontal disease hiv post graduate aggresive periodontitis mds dentistry