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wagner nelson method method of residuals one compartment open model compartment model e plant extraction extraction methods digestion maceration percolation decoction infusion galen galenicals extraction capacity limited kinetics saturation kinetics mixed order kinetics michaelis menten kinetics nonlinearpharmacokinetics nonlinear kinetics catgut surgical aids ligatures sutures surgical dressings biopharmaceutics and pharmacokinetics pharmaceutics pharma pharmaceutical