Genome-wide sequencing initiatives have generated extensive amounts of genotypic and molecular phenotypic data, identifying genetic predispositions (mutations) for developing disease. However, the genetic background is different for every patient. The challenge, therefore, is to understand how to interpret this information to determine how select encoded proteomic variants can not only promote human disease but also influence its response to treatment, and then design effective therapies that are specific for each patient. This aspect of personalized medicine is critically important in the pursuit to eliminate health disparities. As such, major unanswered questions in the field are: how d...
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