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qpcr pcr digital pcr ddpcr plant science plant genetics dna plant genomics liquid biopsy detection cancer dpcr plant yields cancer research liquid biopsies droplet pcr bacteria plasma clinical trials healthcare blockchain distributed ledger technology novel workflow nucleic acid sequencing disease primers probes hybridization algorithm biocide real time pcr fluorogenics micrornas ultra sensitive hrm mutations somatic diodesix methylation biomarker lung cancer cell prostate cancer assays hiv vaccine cells vaccinations inflammation agriculture synthesis plant modification yield grain qtl gene expression disease resistance plant immune responses microbiome modulation gut health gut microbiome oral microbiome nutrition atopic dermatitis skin microbiome skin health public data microcolon bifidobacteria pharmaceuticals circulating tumor tumour cancer detection rna quantification multi-omics omics workflows plant science genetics crispr-cas crispr plant breeding genomics targeted breeding genome editing genetic modification gmo crops phytobiomes