Service workers allow you to control how network requests from web pages are handled. They run scripts in the background to intercept and handle fetch events, allowing web applications to work offline by responding with cached responses. Before service workers, AppCache was used but had limitations. The lifecycle of a service worker involves registration, installation, activation, and controlling pages. Common uses are caching assets, providing offline functionality, and handling network responses. Challenges include debugging failed installations and limitations on credentials and CORS requests. Service workers also enable push notifications and background sync functionality.