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red cells blood igg antibodies antigens preoperative anaemia anaemia erythropoietin autologous blood donation autologous normovolemic haemodilution blood transfusion in surgeries bloodless surgeries blood substitution reducing blood transfusion safe blood transfusion blood transfusion management jehovah's witness transfusion blood management patient blood management immune deficiency transfusion medicine immunoglobulin treatment blood products intravenous immunoglobulin subcutaneous immunoglobulin ivig treatment immunoglobulin scig plasma platelets ffp blood components nucleic acid amplification testing nat rapid antigen test rapid tests eia clia elisa assays screening blood donation donation blood donor medicine transfusion blood group systems blood groups blood transfusion blood bank agglutination antigen antibody reaction iga igd ige igm ivig