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mitochondria macrophages animal models pregnancy hematopoiesis aml leukemia bone marrow stem cells antithrombin deficiency thrombophilia lmpp pbr tspo pk11195 hypoactive sexual desire disorder sexual behavior hsdd myocardial infarction mi estradiol pituitary gland ampk coronory restenosis sexual dysfunction drug administration lenti virus autophagy atherosclerosis blood vessels notch signalling embryonic development embryo implantation stent restenosis stenting cellular barcoding cholesterol bbb blood brain barrier drug delivery liposomes protein c deficiency lactate dehydrogenase src progenitors acute myeloid leukemia oncogens fish pgs ivf in-vitro fertilization genetic screen lif p53 embryo fertilization apoe oxidative stress respiratory chain coagulation benzodiazepine receptors peripheral benzodiazepine metabolic stress myeloid leukemia cml leukemogenesis lic metabolic state metabolism pyruvate kinase pkm2 pkm1 ldh ldha transplantation